The α2β1 Integrin: A Collagen Receptor on Platelets and other Cells

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Integrins and other cell adhesion molecules

1990 • 1,990 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

Amino acid sequence of the human fibronectin receptor.

1987 • 596 citations

Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia

1985 • 518 citations

The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen.

1989 • 422 citations

Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen

1986 • 409 citations

Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen.

1991 • 401 citations

The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others.

1989 • 388 citations

A novel divalent cation-binding site in the a domain of the ?2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1993 • 383 citations

Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells

1991 • 379 citations

Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate--dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome.

1978 • 368 citations

Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor.

1989 • 363 citations

The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain.

1989 • 343 citations

In Vitro and in Vivo Consequences of VLA-2 Expression on Rhabdomyosarcoma Cells

1991 • 323 citations

The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.

1990 • 316 citations

Identification of the Integrin VLA-2 as a Receptor for Echovirus 1

1992 • 310 citations

Distinct cellular functions mediated by different VLA integrin α subunit cytoplasmic domains

1992 • 307 citations

Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive proteins

1989 • 305 citations

Alpha 2 beta 1 integrins from different cell types show different binding specificities.

1990 • 274 citations

Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands

1993 • 260 citations

The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.

1988 • 258 citations

Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin)

1994 • 256 citations

Characterization of a type IV collagen major cell binding site with affinity to the alpha 1 beta 1 and the alpha 2 beta 1 integrins.

1991 • 230 citations

Role of factor VIII-von Willebrand factor and fibronectin in the interaction of platelets in flowing blood with monomeric and fibrillar human collagen types I and III.

1985 • 225 citations

Analysis of alpha 1 beta 1, alpha 2 beta 1 and alpha 3 beta 1 integrins in cell--collagen interactions: identification of conformation dependent alpha 1 beta 1 binding sites in collagen type I.

1992 • 218 citations

Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3 in the VLA family of heterodimers

1988 • 218 citations

Deficiency of platelet membrane glycoprotein Ia associated with a decreased platelet adhesion to subendothelium: a defect in platelet spreading

1986 • 211 citations

Interaction of integrins alpha 3 beta 1 and alpha 2 beta 1: potential role in keratinocyte intercellular adhesion.

1993 • 210 citations

Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies

1993 • 206 citations

Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense α2 integrin mrna in mammary cells

1995 • 206 citations

Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder

1988 • 194 citations

Endothelial cell attachment and spreading on human tenascin is mediated by α2β1 and αVβ 3 integrins

1993 • 194 citations

Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor.

1990 • 193 citations

Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen.

1990 • 191 citations

Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18).

1994 • 184 citations

HPA‐5b (Br^a) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 cases

1991 • 184 citations

Widespread histologic distribution of the alpha 2 beta 1 integrin cell-surface collagen receptor.

1990 • 183 citations

Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib.

1985 • 173 citations

Direct binding of collagen to the I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner

1994 • 164 citations

Shear Rate Dependent Inhibition of Platelet Adhesion and Aggregation on Collagenous Surfaces by Antibodies to Human Factor VIII/von Willebrand Factor

1980 • 156 citations

Variability of integrin alpha 2 beta 1 activity on human platelets

1993 • 155 citations

Isolation and characterization of a platelet surface collagen binding complex related to VLA-2

1988 • 152 citations

Novel functions for calreticulin: interaction with integrins and modulation of gene expression?

1994 • 151 citations

Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin α-subunit-binding protein

1994 • 148 citations

Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody.

1993 • 141 citations

A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques.

1992 • 138 citations

The alpha 2 beta 1 integrin cell surface collagen receptor binds to the alpha 1 (I)-CB3 peptide of collagen.

1990 • 137 citations

Identification of putative ligand binding sites within I domain of integrin α2β1 (VLA-2,CD49b/CD29).

1996 • 136 citations

The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2).

1993 • 129 citations

Platelet glycoproteins Ia, Ic, and IIa are physicochemically indistinguishable from the very late activation antigens adhesion-related proteins of lymphocytes and other cell types.

1988 • 127 citations

An alternative form of the integrin beta 1 subunit with a variant cytoplasmic domain.

1992 • 120 citations

Platelet Unresponsiveness to Collagen: Involvement of Glycoprotein Ia-IIa (α2β1 Integrin) Deficiency Associated with a Myeloproliferative Disorder

1995 • 115 citations

Conformation dependence of integrin-type II collagen binding: Inability of collagen peptides to support α2β1 binding, and mediation of adhesion to denatured collagen by a novel α5β1-fibronectin bridge

1994 • 109 citations

The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression.

1994 • 109 citations

A human integrin β1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing

1990 • 106 citations

Lack of Platelet Response to Collagen Associated with an Autoantibody against Glycoprotein Ia: A Novel Cause of Acquired Qualitative Platelet Dysfunction

1990 • 106 citations

Conformation-dependent platelet adhesion to collagen involving integrin alpha 2 beta 1-mediated and other mechanisms: multiple alpha 2 beta 1-recognition sites in collagen type I.

1994 • 100 citations

The Bra/Brb alloantigen system on human platelets

1989 • 96 citations

Cloning and characterization of a gene that regulates cell adhesion

1992 • 96 citations

Complex patterns of expression suggest extensive roles for the α₂β₁ integrin in murine development

1994 • 91 citations

Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2

1993 • 89 citations

Platelet-reactive sites in collagens type I and type III. Evidence for separate adhesion and aggregatory sites

1989 • 88 citations

Identification of the promoter of the myelomonocytic leukocyte integrin CD11b.

1992 • 82 citations

Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion.

1994 • 79 citations

The collagen receptor alpha 2 beta 1, from MG-63 and HT1080 cells, interacts with a cyclic RGD peptide

1992 • 79 citations

Different β1-integrin collagen receptors on rat hepatocytes and cardiac fibroblasts

1990 • 79 citations

The functional domains of the murine Thy-1 gene promoter.

1991 • 77 citations

Characterization of a specific erythromegakaryocytic enhancer within the glycoprotein IIb promoter.

1992 • 77 citations

The alpha 5 beta 1 fibronectin receptor. Characterization of the alpha 5 gene promoter.

1991 • 76 citations

Characterization of human platelet glycoprotein antigens giving rise to individual immunoprecipitates in crossed-immunoelectrophoresis

1981 • 71 citations

Characterization of the p150,95 leukocyte integrin alpha subunit (CD11c) gene promoter. Identification of cis-acting elements.

1993 • 66 citations

The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms.

1993 • 65 citations

A Technique for Estimation of Platelet-Collagen Adhesion

1969 • 61 citations

Posttransfusion purpura due to an alloantibody reactive with glycoprotein Ia/IIa (anti-HPA-5b)

1991 • 59 citations

Multipotent human hematopoietic cell line K562: Lineage-specific constitutive and inducible antigens

1987 • 58 citations

Regulation of alpha 2 integrin gene expression in cells with megakaryocytic features: a common theme of three necessary elements

1995 • 53 citations

Thrombocytopenia caused by passive transfusion of anti-glycoprotein Ia/IIa alloantibody (anti-HPA-5b)

1992 • 46 citations

Adhesion of human platelets to immobilized trimeric collagen.

1982 • 46 citations

Differential regulation of the alpha 2 beta 1 and alpha IIb beta 3 integrin genes during megakaryocytic differentiation of pluripotential K562 cells.

1992 • 45 citations

Dynamic redistribution of major platelet surface receptors after contact-induced platelet activation and spreading. An immunoelectron microscopy study.

1992 • 38 citations

High-speed platelet adhesion under conditions of rapid flow.

1992 • 37 citations

The VLA-2 (alpha 2 beta 1) I domain functions as a ligand-specific recognition sequence for endothelial cell attachment and spreading: molecular and functional characterization

1994 • 36 citations

Identification of integrin alpha 2 beta 1 as cell surface receptor for the carboxyl-terminal propeptide of type I procollagen.

1994 • 35 citations

Platelet adhesion to cyanogen-bromide fragments of collagen alpha 1(I) under flow conditions

1993 • 26 citations

Human Platelet Glycoprotein Ia

1989 • 24 citations

Br^b, a Platelet Alloantigen Involved in Neonatal Alloimmune Thrombocytopenia

1991 • 21 citations

Glycoprotein Ia/IIa-mediated activation-dependent platelet adhesion to collagen

1992 • 17 citations

Role of glycoprotein IIa (beta 1 subunit of very late activation antigens) in platelet functions

1991 • 13 citations

Divalent cation-dependent structure in the platelet membrane glycoprotein Ia–IIa (VLA-2) complex

1990 • 12 citations