Dimethylsphingosine Regulates Intracellular pH and Ca2+ in Human Monocytes

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Ceramide in apoptosis: an overview and current perspectives

2002 • 770 citations

The complex life of simple sphingolipids

2004 • 624 citations

Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy

2003 • 596 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Quantitation of free sphingosine in liver by high-performance liquid chromatography

1988 • 315 citations

Na-H Exchange-dependent Increase in Intracellular pH Times G2/M Entry and Transition

2003 • 262 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

1989 • 247 citations

N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide

1998 • 229 citations

Alteration in temporal kinetics of Ca²⁺ signaling and control of growth and proliferation

2004 • 167 citations

Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice.

1991 • 123 citations

A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.

1990 • 115 citations

Quick and accurate method to convert BCECF fluorescence to pH_i: Calibration in three different types of cell preparations

1992 • 94 citations

Protein kinase C enhances Ca2+ mobilization in human platelets by activating Na+/H+ exchange.

1988 • 74 citations

Enzymatic synthesis of N,N-dimethyl-sphingosine: Demonstration of the sphingosine: N-methyltransferase in mouse brain

1989 • 73 citations

Sphingosine-dependent Protein Kinase-1, Directed to 14-3-3, Is Identified as the Kinase Domain of Protein Kinase Cδ

2003 • 71 citations

Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.

1991 • 66 citations

The Signal Modulator Protein-14-3-3 Ts a Target of Sphingosine-Dependent or N,N-Dimethylsphingosine-Dependent Kinase in 3T3(A31) Cells

1995 • 65 citations

Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase

1999 • 48 citations

The Action Mode of Lysophosphatidylcholine in Human Monocytes

2004 • 41 citations

Endogenous Substrates of Sphingosine-Dependent Kinases (SDKs) Are Chaperone Proteins: Heat Shock Proteins, Glucose-Regulated Proteins, Protein Disulfide Isomerase, and Calreticulin

1999 • 39 citations

Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils

1992 • 35 citations

Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells.

1998 • 32 citations

Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes

2003 • 15 citations

A sphingosine-dependent protein kinase that specifically phosphorylates 14-3-3 (SDK1) is identified as the kinase domain of PKCδ: a preliminary note

2003 • 11 citations