Pathway-specific regulation of the synthesis of anticoagulantly active heparan sulfate.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Proteoglycans: Structures And Interactions

1991 • 1,596 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

The Purification and Mechanism of Action of Human Antithrombin-Heparin Cofactor

1973 • 1,363 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

1992 • 1,095 citations

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

1988 • 908 citations

Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

1983 • 651 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

1993 • 542 citations

Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate.

1992 • 511 citations

Heparin : chemical and biological properties, clinical applications

1989 • 497 citations

The separation of active and inactive forms of heparin

1976 • 494 citations

Evidence for a 3-O-sulfated D-glucosamine residue in the antithrombin-binding sequence of heparin.

1980 • 489 citations

Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor.

1993 • 449 citations

Structure of the antithrombin-binding site in heparin.

1979 • 362 citations

Cloned bovine aortic endothelial cells synthesize anticoagulantly active heparan sulfate proteoglycan.

1986 • 342 citations

Acceleration of thrombin-antithrombin complex formation in rat hindquarters via heparinlike molecules bound to the endothelium.

1984 • 335 citations

Correlation between structure and function of heparin

1979 • 277 citations

Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3.

1992 • 263 citations

Contribution of monosaccharide residues in heparin binding to antithrombin III

1985 • 249 citations

Cell surface heparan sulfate proteoglycans from human vascular endothelial cells. Core protein characterization and antithrombin III binding properties.

1992 • 245 citations

Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate.

1992 • 241 citations

A proteoglycan form of heparin and its degradation to single-chain molecules.

1978 • 211 citations

Molecular cloning and expression of two distinct cDNA-encoding heparan sulfate proteoglycan core proteins from a rat endothelial cell line.

1992 • 191 citations

Multiple functional domains of the heparin molecule.

1981 • 191 citations

Fine structure of heparan sulfate regulates syndecan-1 function and cell behavior.

1994 • 177 citations

The antithrombin-binding sequence in heparin. Identification of an essential 6-O-sulfate group.

1983 • 176 citations

Molecular cloning and expression of rat liver N-heparan sulfate sulfotransferase.

1992 • 163 citations

Analysis of affinity and structural selectivity in the binding of proteins to glycosaminoglycans: development of a sensitive electrophoretic approach.

1991 • 153 citations

Isolation and characterization of heparan sulfate proteoglycans produced by cloned rat microvascular endothelial cells.

1992 • 152 citations

Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacetylase/N-sulfotransferase from a heparin-producing cell line.

1994 • 152 citations

Contribution of 3-O- and 6-O-sulfated glucosamine residues in the heparin-induced conformational change in antithrombin III

1987 • 133 citations

Structure-function relationships of heparin species

1978 • 126 citations

Stoichiometry of the nitrous acid deaminative cleavage of model amino sugar glycosides and glycosaminoglycuronans

1970 • 122 citations

Molecular organization of heparan sulphate from human skin fibroblasts

1990 • 108 citations

Structure and biological activities of a heparin-derived hexasaccharide with high affinity for basic fibroblast growth factor.

1993 • 107 citations

A single gene in mast cells encodes the core peptides of heparin and chondroitin sulfate proteoglycans.

1986 • 92 citations

Biosynthesis of heparin. Purification of a 110-kDa mouse mastocytoma protein required for both glucosaminyl N-deacetylation and N-sulfation

1991 • 92 citations

Characterization of ryudocan glycosaminoglycan acceptor sites.

1994 • 90 citations

Specificity in the interactions of extracellular matrix proteins with subpopulations of the glycosaminoglycan heparin

1993 • 84 citations

Identification of N-sulphated disaccharide units in heparin-like polysaccharides

1979 • 84 citations

Primary structure of a mouse mastocytoma proteoglycan core protein

1989 • 77 citations

Sequence variation in heparin octasaccharides with high affinity for antithrombin III

1984 • 73 citations

Circular dichroism spectroscopy of heparin-antithrombin interactions

1982 • 71 citations

Biosynthesis of heparin. O-sulfation of the antithrombin-binding region.

1988 • 66 citations

Biosynthesis of heparin. Availability of glucosaminyl 3-O-sulfation sites.

1990 • 63 citations

Analysis of oligosaccharides from heparin by reversed-phase ion-pairing high-performance liquid chromatography

1988 • 62 citations

Search for the heparin antithrombin III-binding site precursor.

1992 • 59 citations

Biosynthesis of heparan sulfate. Coordination of polymer-modification reactions in a Chinese hamster ovary cell mutant defective in N-sulfotransferase

1991 • 56 citations

Regulation of biosynthesis of the basic fibroblast growth factor binding domains of heparan sulfate by heparan sulfate-N-deacetylase/N-sulfotransferase expression.

1993 • 54 citations

Coupling of N-deacetylation and N-sulfation in a Chinese hamster ovary cell mutant defective in heparan sulfate N-sulfotransferase

1991 • 44 citations

Characterization of a cell mutant specifically defective in the synthesis of anticoagulantly active heparan sulfate.

1994 • 42 citations

Asymmetric distribution of sites with high affinity for antithrombin III in rat skin heparin proteoglycans.

1982 • 31 citations

Cell mutants defective in synthesizing a heparan sulfate proteoglycan with regions of defined monosaccharide sequence.

1990 • 27 citations

Nonrandom structural features in the heparin polymer

1989 • 23 citations

A cell-based assay for evaluating the interaction of heparin-like molecules and basic fibroblast growth factor

1992 • 17 citations