Leupeptin-binding site(s) in the mammalian multicatalytic proteinase complex

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A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

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High resolution two-dimensional electrophoresis of proteins.

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A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels

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The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC

1991 • 427 citations

Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.

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Reactions of N-ethylmaleimide with peptides and amino acids

1964 • 396 citations

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

1989 • 370 citations

Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex

1983 • 356 citations

Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes

1991 • 310 citations

The multicatalytic proteinase of mammalian cells

1989 • 242 citations

Proteasomes (multi-protease complexes) as 20 S ring-shaped particles in a variety of eukaryotic cells.

1988 • 225 citations

The Multicatalytic Proteinase

1989 • 145 citations

Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity

1989 • 139 citations

Molecular cloning of cDNA for proteasomes from rat liver: primary structure of component C3 with a possible tyrosine phosphorylation site

1990 • 73 citations

A high molecular weight protease in the cytosol of rat liver. II. Properties of the purified enzyme.

1986 • 56 citations

Active and Inactive Forms of the Transition-state Analog Protease Inhibitor Leupeptin: Explanation of the Observed Slow Binding of Leupeptin to Cathepsin B and Papain

1989 • 56 citations

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous

1991 • 56 citations

N‐Terminal sequence similarities between components of the multicatalytic proteinase complex

1990 • 56 citations

The Drosophila PROS-28.1 gene is a member of the proteasome gene family

1990 • 54 citations

Peptidylglutamyl-peptide hydrolase activity of the multicatalytic proteinase complex: evidence for a new high-affinity site, analysis of cooperative kinetics, and the effect of manganese ions

1992 • 50 citations

Diastereotopic covalent binding of the natural inhibitor leupeptin to trypsin: detection of two interconverting hemiacetals by solution and solid-state NMR spectroscopy

1991 • 33 citations

Eukaryotic protein degradation

1990 • 30 citations

A multicatalytic high-molecular-weight neutral endopeptidase from human kidney

1987 • 30 citations

Catalytic subunits of the multicatalytic proteinase

1991 • 1 citations