Immunosuppressive effects of (2R,5R)-6-heptyne-2,5-diamine an inhibitor of polyamine synthesis: I. Effects on mitogen-induced immunoglobulin production in human cultured lymphocytes.

Recent advances in the biochemistry of polyamines in eukaryotes

1986 • 1,587 citations

Separation of leukocytes from blood and bone marrow. Introduction.

1968 • 692 citations

The T Cell Dependence of B Cell Differentiation Induced by Pokeweed Mitogen

1976 • 409 citations

High-performance liquid chromatographic procedure for the simultaneous determination of the natural polyamines and their monoacetyl derivatives

1980 • 313 citations

Identification of the Aminoaldehydes Produced by the Oxidation of Spermine and Spermidine with Purified Plasma Amine Oxidase

1964 • 229 citations

Increased cellular levels of spermidine or spermine are required for optimal DNA synthesis in lymphocytes activated by concanavalin A.

1975 • 168 citations

Polyamine synthesis during lymphocyte activation

1973 • 118 citations

Factors Controlling the B-Cell Cycle

1986 • 116 citations

Suppression of the formation of polyamines and macromolecules by <scp>dl</scp>-α-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in phytohaemagglutinin-activated human lymphocytes

1979 • 88 citations

Relationship between inhibition of polyamine biosynthesis and DNA replication in activated lymphocytes.

1979 • 73 citations

Inhibition of Lymphocyte Proliferation by Polyamines Requires Ruminant-Plasma Polyamine Oxidase

1979 • 66 citations

Ornithine decarboxylase induction and polyamine biosynthesis are required for the growth of interleukin-2- and interleukin-3-dependent cell lines

1986 • 66 citations

Effects of (2R, 5R)‐6‐heptyne‐2,5‐diamine, a potent inhibitor of <scp>l</scp>‐ornithine decarboxylase, on rat hepatoma cells cultured in vitro

1984 • 54 citations

The role of mitogens and lymphokines in the induction of ornithine decarboxylase (ODC) in T lymphocytes.

1984 • 44 citations

(2R,5R)-6-heptyne-2,5-diamine, an extremely potent inhibitor of mammalian ornithine decarboxylase

1983 • 41 citations

Intracellular polyamine biosynthesis is required for interleukin 2 responsiveness during lymphocyte mitogenesis

1987 • 41 citations

Increased ornithine decarboxylase activity and polyamine biosynthesis are required for optimal cytolytic T lymphocyte induction

1987 • 36 citations

The millipore filter assay technique for measuring tritiated thymidine incorporation into DNA in leucocyte cultures.

1972 • 36 citations

Triggering mechanism of B lymphocytes. II. Induction of ornithine decarboxylase in B cells by anti-immunoglobulin and enhancing soluble factor.

1975 • 23 citations

Selective modulation by alpha-difluoromethylornithine of T-lymphocyte and antibody-mediated cytotoxic responses to mouse tumor allografts.

1986 • 21 citations

Antitumor properties of (2R,5R)-6-heptyne-2,5-diamine, a new potent enzyme-activated irreversible inhibitor of ornithine decarboxylase, in rodents.

1984 • 21 citations

Inhibition by DL-α-difluoromethylornithine of the pokeweed mitogen-induced immunoglobulin production in cultured human lymphocytes

1984 • 9 citations