Increased ornithine decarboxylase activity and polyamine biosynthesis are required for optimal cytolytic T lymphocyte induction

A rapid method for the isolation of functional thymus‐derived murine lymphocytes

1973 • 4,203 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

1978 • 998 citations

Role of Polyamines in the Control of Cell Proliferation and Differentiation

1981 • 935 citations

Anti-proliferative properties of DL-α-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase

1978 • 398 citations

L-Ornithine Decarboxylase: an Essential Role in Early Mammalian Embryogenesis

1980 • 239 citations

Increased cellular levels of spermidine or spermine are required for optimal DNA synthesis in lymphocytes activated by concanavalin A.

1975 • 168 citations

A differentiation factor required for the expression of cytotoxic T-cell function

1982 • 163 citations

Polyamine synthesis during lymphocyte activation

1973 • 118 citations

The Effect of T Cell Growth Factor on the Generation of Cytolytic T Cells

1978 • 113 citations

Depletion of 9L rat brain tumor cell polyamine content by treatment with -?-difluoromethylornithine inhibits proliferation and the G1 to S transition

1981 • 94 citations

Role of polyamines in macromolecular synthesis

1981 • 93 citations

Relationship between inhibition of polyamine biosynthesis and DNA replication in activated lymphocytes.

1979 • 73 citations

Generation of cytotoxic T lymphocytes in vitro. IV. Functional activation of memory cells in the absence of DNA synthesis.

1975 • 66 citations

Ornithine decarboxylase induction and polyamine biosynthesis are required for the growth of interleukin-2- and interleukin-3-dependent cell lines

1986 • 66 citations

Polyamines and their role in protein synthesis

1977 • 57 citations

Cyclic AMP-Dependent Protein Kinase Activation and the Induction of Ornithine Decarboxylase during Lymphocyte Mitogenesis

1979 • 53 citations

The role of mitogens and lymphokines in the induction of ornithine decarboxylase (ODC) in T lymphocytes.

1984 • 44 citations

An essential role for polyamine biosynthesis during human granulopoietic differentiation.

1982 • 42 citations

The requirement for DNA synthesis and gene expression in the generation of cytotoxicity in vitro.

1975 • 37 citations

Generation of cytolytic T lymphocytes in vitro.

1976 • 37 citations

Dissociation of differentiation and proliferation in the primary induction of cytolytic T lymphocytes by alloantigens.

1980 • 31 citations

Effect of polyamine depletion in vivo by DL-alpha-difluoromethylornithine on functionally distinct populations of tumoricidal effector cells in normal and tumor-bearing mice.

1986 • 21 citations