Mutational and Expression Analysis of theNF1Gene Argues Against a Role as Tumor Suppressor in Sporadic Pilocytic Astrocytomas

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The Diagnostic Evaluation and Multidisciplinary Management of Neurofibromatosis 1 and Neurofibromatosis 2

1997 • 1,247 citations

Analysis of the VNTR locus D1S80 by the PCR followed by high-resolution PAGE.

1991 • 931 citations

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1992 • 789 citations

Exhaustive mutation analysis of theNF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects

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Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

1993 • 393 citations

Advances in quantitative PCR technology: 5′ nuclease assays

1998 • 256 citations

Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene

1995 • 253 citations

Confirmation of a Double-Hit Model for the NF1Gene in Benign Neurofibromas

1997 • 239 citations

Distribution of 13 truncating mutations in the neurofibromatosis 1 gene

1995 • 183 citations

The Neurofibromatoses : a pathogenetic and clinical overview

1994 • 169 citations

Loss of neurofibromatosis 1 (NF1) gene expression in NF1‐associated pilocytic astrocytomas

2000 • 160 citations

A Conserved Alternative Splice in the von Recklinghausen Neurofibromatosis (NF1) Gene Produces Two Neurofibromin Isoforms, Both of Which Have GTPase-Activating Protein Activity

1993 • 159 citations

Loss of Neurofibromin Is Associated with Activation of RAS/MAPK and PI3-K/AKT Signaling in a Neurofibromatosis 1 Astrocytoma

2000 • 157 citations

Quantification of splice variants using real-time PCR

2001 • 136 citations

Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

1999 • 135 citations

Loss ofNF1Alleles Distinguish Sporadic from NF1-Associated Pilocytic Astrocytomas

2001 • 126 citations

Differential expression of two types of the neurofibromatosis type 1 (NF1) gene transcripts related to neuronal differentiation.

1991 • 119 citations

A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity.

1993 • 117 citations

Analysis of pilocytic astrocytoma by comparative genomic hybridization

2000 • 100 citations

Deletions on the long arm of chromosome 17 in pilocytic astrocytoma

1993 • 98 citations

Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR

2001 • 96 citations

Expression of the neurofibromatosis 1 (NF1) isoforms in developing and adult rat tissues.

1995 • 86 citations

Toward a Survey of Somatic Mutation of the NF1 Gene in Benign Neurofibromas of Patients with Neurofibromatosis Type 1

2000 • 84 citations

A highly informative CA/GT repeat polymorphism in intron 38 of the human neurofibromatosis type 1 (NF1) gene

1993 • 80 citations

Two CA/GT repeat polymorphisms in intron 27 of the human neurofibromatosis type 1 (NF1) gene

1994 • 77 citations

Microsatellite analysis of loss of heterozygosity on chromosomes 9q, 11 p and 17p in medulloblastomas

1994 • 72 citations

Heterozygosity for the neurofibromatosis 1 (NF1) tumor suppressor results in abnormalities in cell attachment, spreading and motility in astrocytes

2001 • 63 citations

Loss of neurofibromatosis type I (NFI) gene expression in pheochromocytomas from patients without NFI

1995 • 59 citations

Brain tumors predominantly express the neurofibromatosis type 1 gene transcripts containing the 63 base insert in the region coding for GTPase activating protein-related domain

1991 • 59 citations

Up-regulation of specific NF 1 gene transcripts in sporadic pilocytic astrocytomas.

1996 • 52 citations

Increased neurofibromatosis 1 gene expression in astrocytic tumors: positive regulation by p21-ras.

1996 • 48 citations

Modulation of the neurofibromatosis type 1 gene product, neurofibromin, during Schwann cell differentiation

1993 • 46 citations

An RsaI polymorphism in the transcribed region of the neurofibromatosis (NF1)-gene

1994 • 41 citations

Urinary Bladder Transitional Cell Carcinogenesis Is Associated with Down-Regulation of NF1 Tumor Suppressor Gene in Vivo and in Vitro

1999 • 40 citations

Expression of two types of neurofibromatosis type 1 gene transcripts in gastric cancers and comparison of gap activities

1992 • 30 citations

Differential expression of NF1 type I and type II isoforms in sporadic borderline and invasive epithelial ovarian tumors

1999 • 14 citations

Neurofibromatosis

1993 • 12 citations

The two types of mRNAs for neurofibromin isoforms produced by Von Recklinghausen neurofibromatosis (NF1) gene: analysis in human astrocytic tumors

1995 • 2 citations