Loss of neurofibromatosis 1 (NF1) gene expression in NF1‐associated pilocytic astrocytomas

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Histological Typing of Tumours of the Central Nervous System

1993 • 1,493 citations

Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients

1990 • 1,471 citations

The Diagnostic Evaluation and Multidisciplinary Management of Neurofibromatosis 1 and Neurofibromatosis 2

1997 • 1,247 citations

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

1990 • 1,107 citations

The neurofibromatosis type 1 gene encodes a protein related to GAP

1990 • 1,099 citations

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1990 • 984 citations

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1990 • 834 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

1992 • 648 citations

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

1996 • 602 citations

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

1992 • 583 citations

Natural history of optic pathway tumors in children with neurofibromatosis type 1: A longitudinal study

1994 • 528 citations

Optic pathway gliomas in children with neurofibromatosis 1: Consensus statement from the nf1 optic pathway glioma task force

1997 • 456 citations

Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.

1990 • 407 citations

Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

1993 • 393 citations

Optic gliomas in children with neurofibromatosis type 1

1989 • 302 citations

Homozygous Inactivation of theNF1Gene in Bone Marrow Cells from Children with Neurofibromatosis Type 1 and Malignant Myeloid Disorders

1997 • 292 citations

Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene

1995 • 253 citations

Mutations of the NF1 Gene in Children With Juvenile Myelomonocytic Leukemia Without Clinical Evidence of Neurofibromatosis, Type 1

1998 • 199 citations

Identification of NF1 mutations in both alleles of a dermal neurofibroma

1996 • 172 citations

Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas

1997 • 162 citations

Neurofibromatosis: Phenotype, Natural History and Pathogenesis

2000 • 160 citations

Loss of NF1 alleles in phaeochromocytomas from patients with type 1 neurofibromatosis

1992 • 157 citations

THE BIOLOGICAL AND CLINICAL BEHAVIOUR OF PILOCYTIC ASTROCYTOMAS OF THE OPTIC PATHWAYS

1982 • 155 citations

Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

1999 • 135 citations

Deletions on the long arm of chromosome 17 in pilocytic astrocytoma

1993 • 98 citations

Spontaneous Partial Regression of Low-Grade Glioma in Children With Neurofibromatosis-1: A Real Possibility

1999 • 91 citations

Loss of neurofibromin in adrenal gland tumors from patients with neurofibromatosis type I

1994 • 76 citations

Gliomas in neurofibromatosis: a series of 89 cases with evidence for enhanced malignancy in associated cerebellar astrocytomas.

1985 • 67 citations

Developmental regulation of a neuron-specific neurofibromatosis 1 isoform

1999 • 63 citations

Cyclin-dependent Kinase 5 in Lewy Body-like Inclusions in Anterior Horn Cells of a Patient with Sporadic Amyotrophic Lateral Sclerosis

1997 • 54 citations

Up-regulation of specific NF 1 gene transcripts in sporadic pilocytic astrocytomas.

1996 • 52 citations

Increased neurofibromatosis 1 gene expression in astrocytic tumors: positive regulation by p21-ras.

1996 • 48 citations

Acute presentation of a neurogenic sarcoma in a patient with neurofibromatosis type 1: a pathological and molecular explanation

1996 • 37 citations

Increased expression of the neurofibromatosis 1 (NF1) gene product, neurofibromin, in astrocytes in response to cerebral ischemia

1996 • 34 citations

Expression of the neurofibromatosis 1 (NF1) gene in reactive astrocytes in vitro

1995 • 27 citations

Synergistic effect of intrastriatal co-administration of L-NAME and quinolinic acid

1995 • 17 citations