Assay for Evaluating Ribonuclease H-Mediated Degradation of RNA–Antisense Oligonucleotide Duplexes

Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.

1986 • 483 citations

Role of RNase H in hybrid-arrested translation by antisense oligonucleotides.

1988 • 445 citations

Enzyme from Calf Thymus Degrading the RNA Moiety of DNA-RNA Hybrids: Effect on DNA-Dependent RNA Polymerase

1969 • 249 citations

The use of single-stranded DNA and RNase H to promote quantitative ‘hybrid arrest of translation’ of mRNA/DNA hybrids in reticulocyte lysate cell-free translations

1986 • 245 citations

Association of Viral Reverse Transcriptase with an Enzyme degrading the RNA Moiety of RNA-DNA Hybrids

1971 • 226 citations

Isolation and Characterization of an Endonuclease from Escherichia coli Specific for Ribonucleic Acid in Ribonucleic Acid·Deoxyribonucleic Acid Hybrid Structures

1973 • 223 citations

Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells.

1978 • 209 citations

Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts

2002 • 180 citations

Enzymatic completion of mammalian lagging-strand DNA replication.

1994 • 177 citations

Hybrids of RNA and Arabinonucleic Acids (ANA and 2‘F-ANA) Are Substrates of Ribonuclease H

1998 • 175 citations

THE MECHANISM OF ACTION OF RIBONUCLEASE

1969 • 137 citations

The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repair

2000 • 126 citations

Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA

2000 • 120 citations

Ribonuclease H from K562 human erythroleukemia cells. Purification, characterization, and substrate specificity.

1991 • 113 citations

Synthesis and Biophysical Properties of Arabinonucleic Acids (ANA): Circular Dichroic Spectra, Melting Temperatures, and Ribonuclease H Susceptibility of ANA·RNA Hybrid Duplexes

2000 • 105 citations

[2] Creating a ribonuclease-free environment

1987 • 100 citations

Efficient RNase H-Directed Cleavage of RNA Promoted by Antisense DNA or 2‘F-ANA Constructs Containing Acyclic Nucleotide Inserts

2002 • 82 citations

NMR Solution Structure of an Oligonucleotide Hairpin with a 2‘F-ANA/RNA Stem: Implications for RNase H Specificity toward DNA/RNA Hybrid Duplexes

2001 • 77 citations

Cloning of the cDNA encoding the large subunit of human RNase HI, a homologue of the prokaryotic RNase HII

1998 • 69 citations

Yeast RNase H(35) is the counterpart of the mammalian RNase HI, and is evolutionarily related to prokaryotic RNase HII¹

1998 • 47 citations

Purification and characterization of human ribonuclease HII

1994 • 44 citations

Structural Basis of Cleavage by RNase H of Hybrids of Arabinonucleic Acids and RNA^,

2000 • 44 citations

Molecular requirements for degradation of a modified sense RNA strand by Escherichia coli ribonuclease H1

2002 • 43 citations

PROPERTIES OF ARABINONUCLEIC ACIDS (ANA & 20′F-ANA): IMPLICATIONS FOR THE DESIGN OF ANTISENSE THERAPEUTICS THAT INVOKE RNASE H CLEAVAGE OF RNA

2001 • 30 citations

Cloning, Subcellular Localization and Functional Expression of Human RNase HII

1998 • 25 citations

Flexible and Frozen Sugar-Modified Nucleic Acids - Modulation of Biological Activity Through Furanose Ring Dynamics in the Antisense Strand

2002 • 21 citations