Molecular requirements for degradation of a modified sense RNA strand by Escherichia coli ribonuclease H1

Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?

1993 • 1,306 citations

Organofluorine chemistry : principles and commercial applications

1994 • 1,098 citations

How good is fluorine as a hydrogen bond acceptor?

1996 • 694 citations

[22] absorbance melting curves of RNA

1989 • 620 citations

Structure of Ribonuclease H Phased at 2 Å Resolution by MAD Analysis of the Selenomethionyl Protein

1990 • 475 citations

Role of RNase H in hybrid-arrested translation by antisense oligonucleotides.

1988 • 445 citations

Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

1993 • 410 citations

Molecular mechanisms of action of antisense drugs

1999 • 359 citations

Three-dimensional structure of ribonuclease H from E. coli

1990 • 348 citations

Structure of a DNA : RNA Hybrid Duplex

1993 • 245 citations

The use of single-stranded DNA and RNase H to promote quantitative ‘hybrid arrest of translation’ of mRNA/DNA hybrids in reticulocyte lysate cell-free translations

1986 • 245 citations

Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

1989 • 238 citations

Structural details of ribonuclease H from Escherichia coli as refined to an atomic resolution

1992 • 228 citations

Isolation and Characterization of an Endonuclease from Escherichia coli Specific for Ribonucleic Acid in Ribonucleic Acid·Deoxyribonucleic Acid Hybrid Structures

1973 • 223 citations

RNA Hydration: A Detailed Look^,

1996 • 218 citations

Ribonuclease H. An Enzyme Degrading the RNA Moiety of DNA-RNA Hybrids

1970 • 217 citations

How does RNase H recognize a DNA.RNA hybrid?

1991 • 188 citations

Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes

1995 • 182 citations

Site-specific excision from RNA by RNase H and mixed-phosphate-backbone oligodeoxynucleotides.

1990 • 177 citations

Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis.

1990 • 176 citations

Hybrids of RNA and Arabinonucleic Acids (ANA and 2‘F-ANA) Are Substrates of Ribonuclease H

1998 • 175 citations

Sequence Specific Thermodynamic and Structural Properties for DNA.cntdot.RNA Duplexes

1994 • 164 citations

THE MECHANISM OF ACTION OF RIBONUCLEASE

1969 • 137 citations

The DNA strand in DNA.cntdot.RNA hybrid duplexes is neither B-form nor A-form in solution

1993 • 134 citations

Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA

2000 • 120 citations

Binding Affinity and Specificity of Escherichia coli RNase H1: Impact on the Kinetics of Catalysis of Antisense Oligonucleotide−RNA Hybrids

1997 • 115 citations

Crystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: Implications of conformational preorganization for duplex stability

1998 • 113 citations

An improved procedure for derivatization of controlled-pore glass beads for solid-phase oligonucleotide synthesis

1990 • 110 citations

Synthesis and Biophysical Properties of Arabinonucleic Acids (ANA): Circular Dichroic Spectra, Melting Temperatures, and Ribonuclease H Susceptibility of ANA·RNA Hybrid Duplexes

2000 • 105 citations

Kinetic analysis of Escherichia coli RNase H using DNA-RNA-DNA/DNA substrates.

1990 • 101 citations

Solution Structures of DNA·RNA Hybrids with Purine-Rich and Pyrimidine-Rich Strands: Comparison with the Homologous DNA and RNA Duplexes^,

1998 • 101 citations

Role of histidine 124 in the catalytic function of ribonuclease HI from Escherichia coli.

1993 • 82 citations

Oligoribonucleotide Synthesis: The Silyl-Phosphoramidite Method

2003 • 82 citations

Thermal Stability of Escherichia coli Ribonuclease HI and Its Active Site Mutants in the Presence and Absence of the Mg2+ Ion

1996 • 71 citations

Cleavage of Single Strand RNA Adjacent to RNA-DNA Duplex Regions by Escherichia coli RNase H1

1997 • 62 citations

NMR assignments and solution conformation of the DNA · RNA hybrid duplex d(GTGAACTT) · r(AAGUUCAC)

1993 • 52 citations

Kinetic Analysis of Escherichia Coli Ribonuclease HI Using Oligomeric DNA/RNA Substrates Suggests an Alternative Mechanism for the Interaction between the Enzyme and the Substrate

1995 • 46 citations

Poly-2′-deoxy-2′-fluoro-cytidylic acid: enzymatic synthesis, spectroscopic characterization and interaction with poly-inosinic acid

1977 • 41 citations

Studies of the interactions between Escherichia coli ribonuclease HI and its substrate

1994 • 35 citations

Polynucleotide helix geometry and stability. Spectroscopic, antigenic and interferon-inducing properties of deoxyribose-, ribose-, or 2‘-deoxy-2‘-fluororibose-containing duplexes of poly(inosinic acid) . poly(cytidylic acid).

1982 • 34 citations

Catalysis by Escherichia coli Ribonuclease HI Is Facilitated by a Phosphate Group of the Substrate

2000 • 30 citations

Impact of mixed-backbone oligonucleotides on target binding affinity and target cleaving specificity and selectivity by Escherichia coli RNase H

1998 • 29 citations

RNase H1 Can Catalyze RNA/DNA Hybrid Formation and Cleavage with Stable Hairpin or Duplex DNA Oligomers

1998 • 21 citations

Effects of modulation of RNase H production on the recovery of DNA synthesis following UV-irradiation in Escherichia coli

1987 • 19 citations

Absence of a direct role for RNase HI in initiation of DNA replication at the oriC site on the Escherichia coli chromosome

1993 • 18 citations

Interaction of the Basic Protrusion ofEscherichia coliRibonuclease HI with its Substrate

1996 • 17 citations

Recognition of 2′‐hydroxyl groups by Escherichia coli ribonuclease HI

1995 • 15 citations

Stabilities of duplexes and triplexes of dA19 + dT19 with alternating methylphosphonate and phosphodiester linkages.

1993 • 11 citations