Human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

1981 • 910 citations

Bipolar affective disorders linked to DNA markers on chromosome 11

1987 • 826 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences

1982 • 524 citations

Hormone families: pancreatic hormones and homologous growth factors

1980 • 375 citations

Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides.

1986 • 371 citations

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 • 322 citations

Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor

1984 • 267 citations

Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.

1985 • 212 citations

Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases.

1987 • 180 citations

Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene

1986 • 174 citations

The human insulin‐like growth factor II gene contains two development‐specific promoters

1987 • 170 citations

Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene

1987 • 161 citations

Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5' alternative splice sites responsible for multiple mRNAs

1987 • 160 citations

Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA

1985 • 155 citations

Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains

1985 • 121 citations

Evidence for increased recombination near the human insulin gene: implication for disease association studies.

1986 • 113 citations

Polymorphism in the 5′-Flanking Region of the Human Insulin Gene and Its Possible Relation to Type 2 Diabetes

1981 • 96 citations

Linkage map of the short arm of human chromosome 11: location of the genes for catalase, calcitonin, and insulin-like growth factor II.

1985 • 92 citations

Organization of the human genes for insulin‐like growth factors I and II

1986 • 88 citations

Variation in the sequence and modification state of the human insulin gene flanking regions

1982 • 74 citations

Organization and evolution of the rat tyrosine hydroxylase gene

1987 • 73 citations

The PKU locus in man is on chromosome 12.

1984 • 55 citations

Chromosome mapping of genes on the short arm of human chromosome 11: parathyroid hormone gene is at 11p15 together with the genes for insulin, c-Harvey-<i>ras</i> 1, and β-hemoglobin

1985 • 55 citations

Genetic analysis of the hypervariable region flanking the human insulin gene.

1986 • 49 citations

Analysis of a 1963-bp polymorphic region flanking the human insulin gene

1984 • 48 citations

Linkage of tyrosine hydroxylase to four other markers on the short arm of chromosome 11

1986 • 41 citations

New Polymorphisms at the Insulin Locus Increase Its Usefulness as a Genetic Marker

1985 • 19 citations

Report of the committee on the genetic constitution of chromosomes 10, 11, and 12

1982 • 10 citations

Human insulin-related DNA sequences map to chromosomes 2 and 11

1986 • 5 citations