Time-varying prognostic impact of tumour biological factors urokinase (uPA), PAI-1 and steroid hormone receptor status in primary breast cancer

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Regression Models and Life-Tables

1972 • 27,145 citations

Classification and regression trees

1985 • 11,138 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Dangers of Using "Optimal" Cutpoints in the Evaluation of Prognostic Factors

1994 • 1,107 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis.

1993 • 396 citations

Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer

1993 • 367 citations

Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue.

1994 • 296 citations

Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report

1988 • 294 citations

Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer.

1990 • 294 citations

Individual development and uPA–receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer

1995 • 253 citations

The Urokinase Receptor Is a Major Vitronectin-Binding Protein on Endothelial Cells

1996 • 252 citations

Prognostic value of urokinase-type plasminogen activator in 671 primary breast cancer patients.

1992 • 239 citations

Clinical Relevance of the Urokinase-Type and Tissue-Type Plasminogen Activators and of Their Type 1 Inhibitor in Breast Cancer

1991 • 236 citations

Plasminogen activator inhibitor-1 and prognosis in primary breast cancer.

1994 • 230 citations

Ligand binding regulates the directed movement of β1 integrins on fibroblasts

1996 • 223 citations

Prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in completely resected gastric cancer.

1994 • 205 citations

Urokinase-type plasminogen activator (u-PA) antigen is a predictor of early relapse in breast cancer

1990 • 189 citations

Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer.

1994 • 167 citations

Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer

1995 • 150 citations

Co‐expression of urokinase, urokinase receptor and PAI‐1 is necessary for optimum invasiveness of cultured lung cancer cells

1995 • 146 citations

Urokinase (uPA) and PAI-1 Predict Survival in Advanced Ovarian Cancer Patients (FIGO III) after Radical Surgery and Platinum-Based Chemotherapy

1994 • 140 citations

Both the cytosols and detergent extracts of breast cancer tissues are suited to evaluate the prognostic impact of the urokinase-type plasminogen activator and its inhibitor, plasminogen activator inhibitor type 1.

1994 • 123 citations

Impact of urokinase-type plasminogen activator and its inhibitor type 1 on prognosis in cervical cancer of the uterus.

1994 • 107 citations

Overexpression of urokinase receptor in breast cancer cells results in increased tumor invasion, growth and metastasis

1996 • 95 citations

Flexible Methods for Analyzing Survival Data Using Splines, With Applications to Breast Cancer Prognosis

1992 • 67 citations

Inactive urokinase and increased levels of its inhibitor type 1 in colorectal cancer liver metastasis

1994 • 66 citations

Time dependency of the influence of prognostic factors on relapse in breast cancer

1993 • 54 citations

Comparative study of plasminogen activators in cancers and normal mucosae of human urinary bladder.

1989 • 49 citations

Novel methods for the determination of the angiogenic activity of human tumors

1995 • 47 citations

Prognostic Value of Urokinase Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Renal Cell Cancer

1996 • 37 citations

Urokinase plasminogen activator (uPA) and its type 1 inhibitor (PAI-1): Regulators of proteolysis during cancer invasion and prognostic parameters in Breast cancer

1994 • 30 citations

The changing importance of prognostic factors in breast cancer during long-term follow-up

1992 • 20 citations