MEK inhibition augments Raf activity, but has variable effects on mitogenesis, in vascular smooth muscle cells

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Epidermal Growth Factor

1979 • 2,964 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin

1995 • 395 citations

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

1997 • 355 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.

1992 • 284 citations

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex.

1994 • 261 citations

Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation.

1994 • 221 citations

Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases

1997 • 202 citations

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.

1993 • 177 citations

Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase.

1991 • 157 citations

Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.

1992 • 156 citations

Growth inhibition by protein kinase C late in mitogenesis

1987 • 133 citations

Regulation of Mitogen-activated Protein Kinase Phosphatase-1 Expression by Extracellular Signal-related Kinase-dependent and Ca2+-dependent Signal Pathways in Rat-1 Cells

1997 • 121 citations

Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation.

1994 • 97 citations

Raf, but Not MEK or ERK, Is Sufficient for Differentiation of Hippocampal Neuronal Cells

1996 • 89 citations

Inhibition of tyrosine phosphorylation prevents thrombin-induced mitogenesis, but not intracellular free calcium release, in vascular smooth muscle cells.

1992 • 89 citations

Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promoting cell proliferation induced by G-protein-coupled receptor agonist.

1996 • 87 citations

Insulin Stimulation of a MEK-Dependent but ERK-Independent SOS Protein Kinase

1996 • 82 citations

Negative Modulation of Membrane Localization of the Raf-1 Protein Kinase by Hyperphosphorylation

1997 • 70 citations

Angiotensin II type 1 receptor signals through Raf-1 by a protein kinase C-dependent, Ras-independent mechanism.

1996 • 40 citations

Activation of the Xenopus oocyte mitogen-activated protein kinase pathway by Mos is independent of Raf.

1996 • 34 citations

Sequential Modification of Serines 621 and 624 in the Raf-1 Carboxyl Terminus Produces Alterations in Its Electrophoretic Mobility

1997 • 24 citations

Sphingosine reverses growth inhibition caused by activation of protein kinase c in vascular smooth muscle cells

1991 • 21 citations

Divergence in the G-Protein-Coupled Receptor Mitogenic Signalling Pathway at the Level of Raf Kinase

1997 • 13 citations

The Epidermal Growth Factor (EGF) Receptor

1987 • 2 citations