Inhibitors of the major cysteinyl proteinase (GP57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1978 • 4,673 citations

Statistical estimations in enzyme kinetics

1961 • 3,586 citations

A novel cell surface trans-sialidase of trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells

1991 • 420 citations

Determination of the rate constant of enzyme modification by measuring the substrate reaction in the presence of the modifier

1982 • 341 citations

Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases.

1981 • 208 citations

A novel T. cruzi heparin-binding protein promotes fibroblast adhesion and penetration of engineered bacteria and trypanosomes into mammalian cells

1991 • 202 citations

Pathophysiological insights into the cardiomyopathy of Chagas' disease.

1990 • 186 citations

Structural and functional identification of GP57/51 antigen of Trypanosoma cruzi as a cysteine proteinase

1990 • 178 citations

Cell-substrate adhesion during Trypanosoma cruzi differentiation.

1988 • 169 citations

Some kinetic properties of a cysteine proteinase (cruzipain) from Trypanosoma cruzi

1990 • 158 citations

Interaction of Trypanosoma cruzi with heart muscle cells: ultrastructural and cytochemical analysis of endocytic vacuole formation and effect upon myogenesis in vitro.

1986 • 152 citations

Further characterization and partial amino acid sequence of a cysteine proteinase from Trypanosoma cruzi

1989 • 144 citations

The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B

1988 • 139 citations

Cysteinyl Proteinases and Their Selective Inactivation

1990 • 136 citations

Trypanosoma cruzi: characterization and isolation of a 57/51,000 m.w. surface glycoprotein (GP57/51) expressed by epimastigotes and bloodstream trypomastigotes.

1986 • 110 citations

The proteolytic activities of chymopapain, papain, and papaya proteinase III

1985 • 102 citations

Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites

1990 • 85 citations

Identification and isolation of Trypanosoma cruzi trypomastigote cell surface protein with properties expected of a fibronectin receptor

1986 • 78 citations

Subcellular localization of a cysteine proteinase from Trypanosoma cruzi

1989 • 77 citations

Engineering of papain: selective alteration of substrate specificity by site-directed mutagenesis

1991 • 74 citations

A major cysteine proteinase is developmentally regulated in Trypanosoma cruzi

1990 • 73 citations

Chemical structure and antigenic aspects of complexes obtained from epimastigotes of Trypanosoma cruzi

1983 • 70 citations

The C-terminal extension of the major cysteine proteinase (cruzipain) from Trypanosoma cruzi

1991 • 70 citations

Trypanosoma cruzi: description of a highly purified surface antigen defined by human antibodies.

1983 • 69 citations

A major cysteine proteinase is developmentally regulated in Trypanosoma cruzi

1990 • 66 citations

Active center differences between cathepsins L and B: The S₁ binding region

1988 • 66 citations

A surface antigen of Trypanosoma cruzi involved in cell invasion (Tc-85) is heterogeneous in expression and molecular constitution

1989 • 60 citations

Specificity of activated human protein C

1985 • 56 citations

The effect of proteolytic enzymes and protease inhibitors on the interaction Trypanosoma cruzi — fibroblasts

1985 • 50 citations

Preferential action of rat brain cathepsin B as a peptidyl dipeptidase converting pro-opioid oligopeptides

1986 • 48 citations

Self-proteolysis of the cysteine proteinase, cruzipain, from Trypanosoma cruzi gives a major fragment corresponding to its carboxy-terminal domain

1991 • 47 citations

Pathogenesis and immunopathology of chronic Chagas' disease

1987 • 44 citations

Separation of amastigotes and trypomastigotes ofTrypanosoma cruzi from cultured cells

1983 • 38 citations

Lysis of trypanosomes by peptidyl fluoromethyl ketones

1990 • 38 citations

Identification and partial characterization of Trypanosoma cruzi antigens recognized by T cells and immune sera from patients with Chagas' disease

1990 • 33 citations

The Relationship Between Autoimmunity and Chagas’ Disease: Causal or Coincidental?

1985 • 25 citations

Further characterization ofTrypanosoma cruzi GP57/51 as the major antigen expressed by differentiating epimastigotes

1991 • 18 citations

Absence of cyanide-insensitive respiration inSchizosaccharomyces japonicus

1982 • 8 citations