sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.

1989 • 977 citations

Asymptomatic Cardiac Ischemia Pilot (ACIP) Study

1996 • 606 citations

Regulation of Myosin Phosphatase by a Specific Interaction with cGMP- Dependent Protein Kinase Iα

1999 • 514 citations

Molecular mechanism of cGMP-mediated smooth muscle relaxation

2000 • 378 citations

Sildenafil Ameliorates Effects of Inhaled Nitric Oxide Withdrawal

1999 • 344 citations

Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase.

1998 • 269 citations

Pulmonary vascular disease with congenital heart lesions: pathologic features and causes.

1981 • 199 citations

Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells.

1997 • 152 citations

In Utero Placement of Aortopulmonary Shunts

1995 • 150 citations

Augmentation of hypoxic pulmonary vasoconstriction in the isolated perfused rat lung by in vitro antagonists of endothelium-dependent relaxation.

1988 • 145 citations

Impairment of pulmonary endothelium‐dependent relaxation in patients with Eisenmenger's syndrome

1990 • 130 citations

Cyclic-GMP-Binding, Cyclic-GMP-Specific Phosphodiesterase (PDE5) Gene Expression Is Regulated during Rat Pulmonary Development

1998 • 120 citations

Diagnosis and management of postoperative pulmonary hypertensive crisis.

1979 • 112 citations

Disruption of cGMP production in pulmonary arteries isolated from fetal lambs with pulmonary hypertension

1995 • 104 citations

Effects of Dipyridamole and Inhaled Nitric Oxide in Pediatric Patients with Pulmonary Hypertension

1998 • 97 citations

Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension

1998 • 97 citations

Ventilation and oxygenation induce endothelial nitric oxide synthase gene expression in the lungs of fetal lambs.

1997 • 96 citations

Mechanisms of Reduced Nitric Oxide/cGMP–Mediated Vasorelaxation in Transgenic Mice Overexpressing Endothelial Nitric Oxide Synthase

2000 • 93 citations

Coordinated Regulation of Genes of the Nitric Oxide and Endothelin Pathways during the Development of Pulmonary Hypertension in Fetal Lambs

1998 • 89 citations

Pulmonary hypertension in children: perioperative management

1986 • 88 citations

Altered Regulation of the ET-1 Cascade in Lambs with Increased Pulmonary Blood Flow and Pulmonary Hypertension

2000 • 75 citations

Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow

1996 • 69 citations

The cGMP-specific Phosphodiesterase Inhibitor E4021 Dilates the Pulmonary Circulation

1999 • 37 citations

Phosphodiesterase 5 (PDE5) Enzyme Activity and Gene Expression Are Altered in Newborn Lambs with Persistent Pulmonary Hypertension. • 1585

1997 • 7 citations

Phosphodiesterase 5 (PDE5) Enzyme Activity and Gene Expression Are Altered in Newborn Lambs with Persistent Pulmonary Hypertension (PPHN)

1999 • 5 citations

Elevated plasma levels of atrial natriuretic peptide (ANP) as a possible aggravating agent in congestive heart failure

1989 • 2 citations