Ventilation and oxygenation induce endothelial nitric oxide synthase gene expression in the lungs of fetal lambs.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Biostatistical Analysis.

1975 • 10,200 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Regulatory Functions of the Vascular Endothelium

1990 • 1,899 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress

1995 • 572 citations

Nitric Oxide Synthesis by Cultured Endothelial Cells Is Modulated by Flow Conditions

1995 • 549 citations

Hemodynamic forces are complex regulators of endothelial gene expression

1995 • 547 citations

Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells

1994 • 520 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

The Nitric Oxide Synthase Family of Proteins

1994 • 465 citations

Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth

1990 • 447 citations

Fetal and Neonatal Pulmonary Circulation

1979 • 336 citations

Thrombin receptor expression in normal and atherosclerotic human arteries.

1992 • 318 citations

Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium.

1993 • 300 citations

Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress

1995 • 297 citations

The vascular resistance of the foetal and newly ventilated lung of the lamb

1964 • 270 citations

Changes in the lungs of the new‐born lamb

1953 • 269 citations

Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells

1994 • 248 citations

Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus

1992 • 229 citations

Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen.

1995 • 204 citations

Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs.

1994 • 170 citations

Secondary flow and turbulence in a cone-and-plate device

1984 • 170 citations

Regulation of Pulmonary Vascular Tone in the Perinatal Period

1995 • 162 citations

Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung

1994 • 156 citations

The Onset of Breathing at Birth Stimulates Pulmonary Vascular Prostacyclin Synthesis

1984 • 141 citations

Shear‐induced platelet‐derived growth factor gene expression in human endothelial cells is mediated by protein kinase C

1992 • 134 citations

Treatment of persistent pulmonary hypertension in the newborn lamb by inhaled nitric oxide

1993 • 133 citations

Increasing oxygen tension dilates fetal pulmonary circulation via endothelium-derived relaxing factor

1993 • 132 citations

Hemodynamic effects of exogenous nitric oxide in ovine transitional pulmonary circulation

1992 • 130 citations

Fluid shear stress stimulates platelet-derived growth factor expression in endothelial cells

1993 • 119 citations

Pulmonary endothelial nitric oxide production is developmentally regulated in the fetus and newborn

1993 • 113 citations

Laminar Flow Stimulates ATP- and Shear Stress-Dependent Nitric Oxide Production in Cultured Bovine Endothelial Cells

1994 • 113 citations

Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development.

1994 • 112 citations

Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells

1996 • 112 citations

Oxygen modulates endothelium-derived relaxing factor production in fetal pulmonary arteries

1992 • 105 citations

Oxygen modulates nitric oxide production selectively in fetal pulmonary endothelial cells.

1994 • 94 citations

M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs

1993 • 88 citations

Effects of Birth-Related Events on Blood Flow Distribution

1987 • 87 citations

Maturation-related changes in endothelial nitric oxide synthase immunolocalization in developing ovine lung

1994 • 86 citations

Abundant adrenal-specific transcription of the human P450c21A “pseudogene”

1993 • 85 citations

Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development

1995 • 79 citations

Oxygen upregulates nitric oxide synthase gene expression in ovine fetal pulmonary artery endothelial cells

1996 • 79 citations

Biosynthesis And Metabolism Of Endothelium-Derived Nitric Oxide

1990 • 72 citations

Expression of neuronal nitric oxide synthase corresponds to regions of selective vulnerability to hypoxia-ischaemia in the developing rat brain

1995 • 69 citations

EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs

1992 • 68 citations

Mechanisms of stimulation of pulmonary prostacyclin synthesis at birth

1984 • 58 citations

Chronic Hypoxia Differentially Regulates α ₁ -Adrenergic Receptor Subtype mRNAs and Inhibits α ₁ -Adrenergic Receptor–Stimulated Cardiac Hypertrophy and Signaling

1995 • 51 citations

L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs

1991 • 46 citations

Acetylcholine increases pulmonary blood flow in intact fetuses via endothelium-dependent vasodilation

1992 • 46 citations

In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue

1991 • 34 citations

Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells

1996 • 15 citations

The Onset of Breathing at Birth Stimulates Pulmonary Vascular Prostacyclin Synthesis

1984 • 11 citations

Regulation of Pulmonary Vascular Tone in the Perinatal Period

1995 • 8 citations

DIPYRIDAMOLE ENHANCES RELAXATIONS AND cGMP GENERATION TO NITRIC OXIDE IN LAMBS WITH PERSISTENT PULMONARY HYPERTENSION (PPHN). • 2090

1996 • 4 citations