Torsional-strain considerations in enzymology

Geometrical reaction coordinates. II. Nucleophilic addition to a carbonyl group

1973 • 760 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1974 • 548 citations

Mechanism of Action of Proteolytic Enzymes

1965 • 473 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1973 • 449 citations

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

1974 • 431 citations

The non-planar amide group

1971 • 352 citations

Carbon nuclear magnetic resonance studies of the histidine residue in α-lytic protease. Implications for the catalytic mechanism of serine proteases

1973 • 239 citations

Stereochemistry of Reaction Paths as Determined from Crystal Structure Data—A Relationship between Structure and Energy

1975 • 229 citations

Environmentally Sensitive Tyrosyl Residues. Nitration with Tetranitromethane^*

1967 • 190 citations

Leaving group specificity in the chymotrypsin-catalyzed hydrolysis of peptides. Stereochemical interpretation

1973 • 125 citations

Detailed Mechanism of Interaction of Bovine β-Trypsin with Soybean Trypsin Inhibitor (Kunitz)

1973 • 122 citations

High resolution nuclear magnetic resonance studies of the active site of chymotrypsin

1974 • 117 citations

The Cysteine proteinases

1976 • 115 citations

Modification of carboxyl groups in bovine carboxypeptidase A. I. Inactivation of the enzyme by N-ethyl-5-phenylisoxazolium-3'-sulfonate (Woodward's reagent K)

1971 • 98 citations

The Functional Tyrosyl Residues of Carboxypeptidase A. Nitration with Tetranitromethane^*

1967 • 86 citations

Kinetics Of The Interaction Of Bovine Pancreatic Trypsin Inhibitor (Kunitz) With α-Chymotrypsin

1974 • 74 citations

The structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1975 • 72 citations

Affinity labeling of bovine carboxypeptidase A γLeu by N-bromoacetyl-N-methyl-L-phenylalanine. I. Kinetics of inactivation

1971 • 55 citations

The Hydrolysis of Imidate Salts. Stereoelectronic Control in the Cleavage of the Hemiorthoamide Tetrahedral Intermediate

1975 • 50 citations

Binding of peptides to elastase. Implications for the mechanism of substrate hydrolysis

1974 • 47 citations

On the mechanism of catalysis by carboxypeptidase A

1976 • 45 citations

Negatively co-operative ligand binding

1973 • 35 citations

The Mechanism of Hydrolysis of Imidate Salts. The Importance of Stereoelectronic Control and pH of the Reaction Medium on the Cleavage of Tetrahedral Intermediates

1975 • 32 citations

The reactivity of noncoplanar double bonds

1972 • 25 citations

Mechanism of the .alpha.-chymotrypsin-catalyzed hydrolysis of specific amide substrates

1972 • 25 citations

Mechanism of serine protease action. Ionization behavior of tetrahedral adduct between α‐lytic protease and tripeptide aldehyde studied by carbon‐13 magnetic resonance

1975 • 25 citations

Torsional strain considerations in the mechanism of the proteolytic enzymes, with particular application to carboxypeptidase A

1975 • 22 citations

Color, Conformation, and Catalysis

1974 • 14 citations