High resolution nuclear magnetic resonance studies of the active site of chymotrypsin

Proton Transfer, Acid‐Base Catalysis, and Enzymatic Hydrolysis. Part I: ELEMENTARY PROCESSES

1964 • 1,743 citations

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

1969 • 1,060 citations

Direct Evidence for the Presence of Histidine in the Active Center of Chymotrypsin^*

1963 • 649 citations

Structure of Subtilisin BPN′ at 2.5 Å Resolution

1969 • 543 citations

Structure of crystalline α-chymotrypsin

1968 • 435 citations

Three-dimensional Structure of Tosyl-elastase

1970 • 299 citations

Conformational equilibria in α- and δ-chymotrypsin

1972 • 250 citations

Carbon nuclear magnetic resonance studies of the histidine residue in α-lytic protease. Implications for the catalytic mechanism of serine proteases

1973 • 239 citations

[5] Chymotrypsinogens—chymotrypsins

1970 • 206 citations

Substrate binding site in bovine chymotrypsin A_γ. Crystallographic study using peptide chloromethyl ketones as site-specific inhibitors

1971 • 181 citations

High resolution nuclear magnetic resonance study of the histidine—Aspartate hydrogen bond in chymotrypsin and chymotrypsinogen

1972 • 152 citations

Three-dimensional Fourier Synthesis of Tosyl-elastase at 3.5 Å Resolution

1970 • 144 citations

High resolution nuclear magnetic resonance studies of the active site of chymotrypsin

1974 • 123 citations

Studies of the activity of chymotrypsin

1970 • 108 citations

[1] Principles of active site titration of proteolytic enzymes

1970 • 101 citations

Nuclear magnetic resonance study of cyanoferrimyoglobin; Identification of pseudocontact shifts

1970 • 91 citations

Nuclear magnetic resonance study of exchangeable protons in ferrocytochrome c

1973 • 75 citations

Conformation of the high pH form of chymotrypsin

1969 • 69 citations

FAST REACTIONS OF IMIDAZOLE STUDIED WITH RELAXATION SPECTROMETRY

1960 • 65 citations

High resolution nuclear magnetic resonance study of base pairing in four purified transfer RNA molecules

1971 • 61 citations

Reevaluation of the activation of bovine chymotrypsinogen A

1971 • 49 citations

Nuclear magnetic resonance studies of human carbonic anhydrase B. histidine residues

1971 • 43 citations

Conformational changes accompanying the formation of chymotrypsin-substrate complexes. Evidence for the involvement of an N-terminal α-amino group in the activity and the conformation of the enzyme

1964 • 40 citations

Conformation and Activity of Chymotrypsin: The p H-Dependent, Substrate-Induced Proton Uptake

1968 • 31 citations

Proton nuclear magnetic resonance studies of histidine residues in rat and other rodent pancreatic ribonucleases. Effects of ph and inhibitors

1973 • 30 citations

Assignment of an exchangeable low-field nitrogen-hydrogen proton resonance of ribonuclease A to the active-site hisitidine-119

1973 • 27 citations

Studies of the histidine residues of carbonic anhydrases using high-field proton magnetic resonance

1972 • 27 citations

Structure of crystalline methyl-chymotrypsin

1972 • 22 citations