Cellular Distribution of Phosphorothioate Oligonucleotide Following Intravenous Administration in Mice

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

1996 • 1,498 citations

Macrophages ingest and are activated by bacterial DNA.

1996 • 579 citations

Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

1991 • 551 citations

Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

1989 • 510 citations

Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides.

1995 • 308 citations

Immune Activation by Bacterial DNA: A New Genetic Code

1996 • 304 citations

Antisense oligonucleotides: towards clinical trials

1996 • 268 citations

Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate.

1994 • 252 citations

Complement Activation and Hemodynamic Changes Following Intravenous Administration of Phosphorothioate Oligonucleotides in the Monkey

1994 • 240 citations

Comparison of Cellular Binding and Uptake of Antisense Phosphodiester, Phosphorothioate, and Mixed Phosphorothioate and Methylphosphonate Oligonucleotides

1993 • 231 citations

Effect of different chemically modified oligodeoxynucleotides on immune stimulation

1996 • 171 citations

Cellular distribution of phosphorothioate oligodeoxynucleotides in normal rodent tissues.

1997 • 147 citations

In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells

1997 • 147 citations

Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies.

1996 • 140 citations

Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302).

1997 • 137 citations

Pharmacokinetics of an anti—human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV-infected subjects*

1995 • 130 citations

Pharmacokinetics, metabolism, and elimination of a 20-mer phosphorothioate oligodeoxynucleotide (cgp 69846a) after intravenous and subcutaneous administration

1997 • 121 citations

Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a four-week study in cynomolgus monkeys

1997 • 119 citations

In VivoToxicological Effects ofrelA Antisense Phosphorothioates in CD-1 Mice

1994 • 108 citations

A pharmacokinetic evaluation of 14C-labeled afovirsen sodium in patients with genital warts

1994 • 79 citations

Mixed Backbone Oligonucleotides: Improvement in Oligonucleotide-induced Toxicity In Vivo

1998 • 78 citations

Pharmacokinetics, tissue distribution, and stability of antisense oligodeoxynucleotide phosphorothioate ISIS 3466 in mice.

1994 • 71 citations

Large-Scale Synthesis, Purification, and Analysis of Oligodeoxynucleotide Phosphorothioates

1994 • 66 citations

Stage-specific oligonucleotide uptake in murine bone marrow B-cell precursors

1994 • 65 citations

Oligonucleotide uptake in human hematopoietic cells is increased in leukemia and is related to cellular activation

1996 • 62 citations

Disposition of oligonucleotides in isolated perfused rat kidney: involvement of scavenger receptors in their renal uptake.

1996 • 58 citations

Comparison of the toxicity profiles of ISIS 1082 and ISIS 2105, phosphorothioate oligonucleotides, following subacute intradermal administration in Sprague-Dawley rats

1997 • 41 citations

Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man

1995 • 29 citations

One-step labelling of oligonucleotides with fluoresceine during automated synthesis

1990 • 28 citations

Binding of Antisense Phosphorothioate Oligonucleotides to Murine Lymphocytes Is Lineage Specific and Inducible

1992 • 27 citations

Distribution of the Cellular Uptake of Phosphorothioate Oligodeoxynucleotides in the Rat Kidney in vivo

1997 • 23 citations

Repeat-dose toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after bolus intravenous administration to cynomolgus monkeys.

1996 • 15 citations

HIV-1revAntisense Phosphorothioate Oligonucleotide Binding to Human Mononuclear Cells Is Cell Type Specific and Inducible

1994 • 8 citations

Pharmacokinetics and distribution of a 33P-labeled anti-human immunodeficiency virus oligonucleotide (AR177) after single- and multiple-dose intravenous administration to rats.

1997 • 5 citations