Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis

NCT03278730

PHASE2INTERVENTIONAL

University of Pecs

296 participants

Started 2027-01 · Completed 2027-02-28

Status: Suspended (as of 12-23-2025)

Conditions

Sepsis

Interventions

DRUG: Para-Tyrosine supplementation DRUG: Placebo solution

Linked Papers (from SciSciNet-V2)

Total Papers25

Background

9

Result

0

Derived

0

Unknown

16

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

Meta-and ortho-Tyrosine are known markers of oxidative stress, while the physiological isomer, para-Tyrosine is suggested the antagonize the effects of meta- and ortho-Tyrosine. The changes in the serum levels of meta- and ortho-Tyrosine have been found to be paralel to that of the common sepsis markers. The hypothesis of the study is, that supplementation of para-Tyrosine (p-Tyr) in the early phase of sepsis may diminish some specific inflammatory procedures and thus may have a favourable impact on the disease progress, and consequently on the mortality.

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Background Papers18

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

20,074 citations

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

20,074 citations

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

7,189 citations

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

7,189 citations

Whole Body Protein Kinetics in Severely Septic Patients

Whole Body Protein Kinetics in Severely Septic Patients

Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients

Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients

Short-term amino acid infusion improves protein balance in critically ill patients

Short-term amino acid infusion improves protein balance in critically ill patients

Role of Tyrosine Isomers in Acute and Chronic Diseases Leading to Oxidative Stress - A Review

Role of Tyrosine Isomers in Acute and Chronic Diseases Leading to Oxidative Stress - A Review

Tyrosine isomers and hormonal signaling: A possible role for the hydroxyl free radical in insulin resistance

Tyrosine isomers and hormonal signaling: A possible role for the hydroxyl free radical in insulin resistance

Association of plasmaortho-tyrosine/para-tyrosine ratio with responsiveness of erythropoiesis-stimulating agent in dialyzed patients

Association of plasmaortho-tyrosine/para-tyrosine ratio with responsiveness of erythropoiesis-stimulating agent in dialyzed patients

Insulin Therapy of Nondiabetic Septic Patients Is Predicted bypara-Tyrosine/Phenylalanine Ratio and by Hydroxyl Radical-Derived Products of Phenylalanine

Insulin Therapy of Nondiabetic Septic Patients Is Predicted bypara-Tyrosine/Phenylalanine Ratio and by Hydroxyl Radical-Derived Products of Phenylalanine

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers16

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

12,726 citations

The Effects of Ibuprofen on the Physiology and Survival of Patients with Sepsis

Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

RAPID COMMUNICATION: Inhibitory Effect of a Two Day Fast on Reactive Oxygen Species (ROS) Generation by Leucocytes and Plasma Ortho-Tyrosine and Meta-Tyrosine Concentrations

The Effect of Repeated Ozone Exposures on Inflammatory Markers in Bronchoalveolar Lavage Fluid and Mucosal Biopsies

Amino acid kinetics in patients with sepsis

A double-blind, prospective, randomized study of glutamine-enriched compared with standard peptide-based feeding in critically ill patients

Urinary ortho-tyrosine excretion in diabetes mellitus and renal failure: Evidence for hydroxyl radical production

Accumulation of the hydroxyl free radical markers meta-, ortho-tyrosine and DOPA in cataractous lenses is accompanied by a lower protein and phenylalanine content of the water-soluble phase

Concomitant Tumor Resistance: The Role of Tyrosine Isomers in the Mechanisms of Metastases Control

Altered balance of the aminogram in patients with sepsis – The relation to mortality

Brain lipid peroxidation and hydroxy radical attack following the intravenous infusion of hydrogen peroxide in an infant

Tyrosine Isomers Mediate the Classical Phenomenon of Concomitant Tumor Resistance

Incorporation of Ortho- and Meta-Tyrosine Into Cellular Proteins Leads to Erythropoietin-Resistance in an Erythroid Cell Line

Elevated Vascular Level of ortho-Tyrosine Contributes to the Impairment of Insulin-Induced Arterial Relaxation

Para-Tyrosine Supplementation Improves Insulin- and Liraglutide- Induced Vasorelaxation in Cholesterol-Fed Rats