Inhibition of serine proteases by peptidyl fluoromethyl ketones

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

A MODIFIED SPECTROPHOTOMETRIC DETERMINATION OF CHYMOTRYPSIN, TRYPSIN, AND THROMBIN

1959 • 1,705 citations

Binding Energy, Specificity, and Enzymic Catalysis: The Circe Effect

1975 • 844 citations

[17] The kinetics of reversible tight-binding inhibition

1979 • 679 citations

Tight-binding inhibitors—I

1975 • 497 citations

TRANSITION STATE ANALOG INHIBITORS AND ENZYME CATALYSIS

1976 • 415 citations

[47] A centrifuged-column procedure for the measurement of ligand binding by beef heart F1

1979 • 365 citations

Fluoro ketone inhibitors of hydrolytic enzymes

1985 • 336 citations

Sensitive substrates for human leukocyte and porcine pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases

1979 • 270 citations

Use of peptide aldehydes to generate transition-state analogs of elastase

1973 • 181 citations

Carbonyl Addition Reactions: Factors Affecting the Hydrate–Hemiacetal and Hemiacetal–Acetal Equilibrium Constants

1975 • 171 citations

Thiol Addition to the Carbonyl Group. Equilibria and Kinetics¹

1966 • 157 citations

Synthesis of peptide fluoromethyl ketones and the inhibition of human cathepsin B

1985 • 125 citations

Dependence of the kinetic parameters for elastase-catalyzed amide hydrolysis on the length of peptide substrates

1973 • 110 citations

The Formation of Anhydrochymotrypsin by Removing the Elements of Water from the Serine at the Active Site¹

1966 • 109 citations

Active-site specific inhibitors of elastase

1973 • 88 citations

Elastase-catalyzed hydrolysis of p-nitrophenyl trimethylacetate

1968 • 56 citations

Kinetics of the reaction of chymotrypsin A_α with peptide chloromethyl ketones in relation to its subsite specificity

1973 • 55 citations

Carbon-13 NMR spectroscopy of "transition-state analog" complexes of N-acetyl-L-phenylalaninal and .alpha.-chymotrypsin

1984 • 51 citations

Evidence for hemiacetal formation between N-acyl-L-phenylalaninals and .alpha.-chymotrypsin by cross-saturation nuclear magnetic resonance spectroscopy

1979 • 50 citations

Crystallographic and kinetic investigations of the covalent complex formed by a specific tetrapeptide aldehyde and the serine protease from Streptomyces griseus.

1979 • 44 citations

Carbon-13 NMR study of the ionizations within a trypsin-chloromethyl ketone inhibitor complex

1985 • 39 citations

The binding of specific and non‐specific aldehyde substrate analogs to α‐chymotrypsin

1975 • 21 citations