Negatively Charged Reactants as Probes in the Study of the Essential Mercaptide‐Imidazolium Ion‐Pair of Thiolenzymes

Tissue sulfhydryl groups

1959 • 25,130 citations

Binding of chloromethyl ketone substrate analogs to crystalline papain

1976 • 352 citations

Studies of asymmetry in the three-dimensional structure of lobster D-glyceraldehyde-3-phosphate dehydrogenase.

1975 • 330 citations

Studies of asymmetry in the three-dimensional structure of lobster D-glyceraldehyde-3-phosphate dehydrogenase

1975 • 267 citations

An agarose mercurial column for the separation of mercaptopapain and nonmercaptopapain

1970 • 194 citations

Mercaptide—imidazolium ion‐pair: The reactive nucleophile in papain catalysis

1974 • 139 citations

Atomic coordinates for subtilisin BPN′ (or Novo)

1971 • 120 citations

On the Mode of Activation of the Catalytically Essential Sulfhydryl Group of Papain

1973 • 112 citations

Ion‐Pair Formation as a Source of Enhanced Reactivity of the Essential Thiol Group of <scp>d</scp>‐Glyceraldehyde‐3‐Phosphate Dehydrogenase

1975 • 76 citations

Spectrophotometric determination of mercaptide ion, an activated form of SH‐group in thiol enzymes

1974 • 60 citations

Stereospecific Alkylation with Asymmetric Reagents

1968 • 58 citations

Reaction of the Sulfhydryl Group of Papain with Chloroacetic Acid

1969 • 45 citations

13 Papain, X-Ray Structure

1971 • 38 citations

Reaction of papain with α-bromo-β-(5-imidazolyl)propionic acid

1972 • 36 citations

The mechanism of action of thiolenzymes

1977 • 33 citations

On the Reactivity of the Thiol Group of Thiolsubtilisin

1973 • 30 citations

Use of Methyl Iodide for Probing the Polarity of the Immediate Environment of—SH Groups in Thiolenzymes

1976 • 24 citations

Effect of the Immediate Environment on the Reactivity of the Essential—SH Group of Papain

1976 • 15 citations

Subtilisin BPN': Tertiary Structure and Inhibitor Binding

1970 • 8 citations