Lessons in experimental ischemia for clinical stroke medicine.

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia

2002 • 5,301 citations

Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest

2002 • 5,064 citations

Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II)

1998 • 3,417 citations

Intravenous Administration of Human Umbilical Cord Blood Reduces Behavioral Deficits After Stroke in Rats

2001 • 1,230 citations

Human Bone Marrow Stem Cells Exhibit Neural Phenotypes and Ameliorate Neurological Deficits after Grafting into the Ischemic Brain of Rats

2002 • 828 citations

Toward Wisdom From Failure

2002 • 619 citations

Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

1990 • 589 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

Cooling for Acute Ischemic Brain Damage (COOL AID)

2001 • 409 citations

Multiple Molecular Penumbras after Focal Cerebral Ischemia

2000 • 398 citations

Matrix Metalloproteinase Inhibition Prevents Oxidative Stress-Associated Blood–Brain Barrier Disruption after Transient Focal Cerebral Ischemia

2001 • 382 citations

Inflammatory Cell Adhesion Molecules in Ischemic Cerebrovascular Disease

2002 • 375 citations

Matrix Metalloproteinase Expression Is Related to Hemorrhagic Transformation After Cardioembolic Stroke

2001 • 297 citations

Mechanisms of acute cerebral infarctions in patients with middle cerebral artery stenosis: A diffusion‐weighted imaging and microemboli monitoring study

2002 • 254 citations

Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice

2002 • 246 citations

Flow Cytometric Analysis of Inflammatory Cells in Ischemic Rat Brain

2002 • 242 citations

Clonal Human (hNT) Neuron Grafts for Stroke Therapy

2002 • 235 citations

Indefatigable CA1 Sector Neuroprotection with Mild Hypothermia Induced 6 Hours after Severe Forebrain Ischemia in Rats

1999 • 224 citations

Dehydroascorbic acid, a blood–brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

2001 • 218 citations

Interferon α/β Promotes Cell Survival by Activating Nuclear Factor κB through Phosphatidylinositol 3-Kinase and Akt

2001 • 197 citations

Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke

2002 • 190 citations

Influence of Mild Hypothermia on Inducible Nitric Oxide Synthase Expression and Reactive Nitrogen Production in Experimental Stroke and Inflammation

2002 • 190 citations

Estrogen and Bcl-2: Gene Induction and Effect of Transgene in Experimental Stroke

2001 • 179 citations

Examination of Several Potential Mechanisms for the Negative Outcome in a Clinical Stroke Trial of Enlimomab, a Murine Anti-Human Intercellular Adhesion Molecule-1 Antibody: A Bedside-to-Bench Study

2001 • 167 citations

Erythropoietin - a novel concept for neuroprotection

2001 • 167 citations

The Type 1 Interleukin-1 Receptor Is Essential for the Efficient Activation of Microglia and the Induction of Multiple Proinflammatory Mediators in Response to Brain Injury

2002 • 157 citations

Overexpression of HSP72 after Induction of Experimental Stroke Protects Neurons from Ischemic Damage

2001 • 148 citations

Ultrastructural Changes of Neuronal Mitochondria After Transient and Permanent Cerebral Ischemia

2002 • 147 citations

Neuroprotective adaptations in hibernation: therapeutic implications for ischemia-reperfusion, traumatic brain injury and neurodegenerative diseases

2001 • 145 citations

Application of magnetic resonance to animal models of cerebral ischemia

2001 • 139 citations

Dynamic patterns of USPIO enhancement can be observed in macrophages after ischemic brain damage

2001 • 139 citations

Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response After Postischemic Injury

2002 • 120 citations

Mild Hypothermia Attenuates Cytochrome C Release but Does Not Alter Bcl-2 Expression or Caspase Activation after Experimental Stroke

2002 • 118 citations

Reversal of Early Diffusion-Weighted Magnetic Resonance Imaging Abnormalities Does Not Necessarily Reflect Tissue Salvage in Experimental Cerebral Ischemia

2001 • 117 citations

Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons

2001 • 109 citations

Neuroprotection and P450 2C11 Upregulation After Experimental Transient Ischemic Attack

2002 • 105 citations

NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat

2001 • 103 citations

Aging has a complex effect on a rat model of ischemic stroke

2002 • 92 citations

Neuroprotective properties of epoetin alfa

2002 • 89 citations

Neuroprotective effect of treatment with human albumin in permanent focal cerebral ischemia: histopathology and cortical perfusion studies

2001 • 87 citations

Prediction of Hemorrhagic Transformation After Thrombolytic Therapy of Clot Embolism

2002 • 77 citations

Anesthetic methods in rats determine outcome after experimental focal cerebral ischemia: mechanical ventilation is required to obtain controlled experimental conditions

2002 • 77 citations

Beneficial effects of α-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain

2002 • 70 citations

Detection of Deoxygenation-Related Signal Change in Acute Ischemic Stroke Patients by T2*-Weighted Magnetic Resonance Imaging

2002 • 69 citations

Extension of the Therapeutic Window for Recombinant Tissue Plasminogen Activator With Argatroban in a Rat Model of Embolic Stroke

2001 • 68 citations

Inflammatory Response and Glutathione Peroxidase in a Model of Stroke

2002 • 62 citations

Nitrones as Neuroprotectants and Antiaging Drugs

2002 • 62 citations

Interferon-β administration confers a beneficial outcome in a rabbit model of thromboembolic cerebral ischemia

2002 • 61 citations

Inhibition of Factor IX(a) Is Protective in a Rat Model of Thromboembolic Stroke

2002 • 55 citations

What Is Effective in Malignant Middle Cerebral Artery Infarction: Reperfusion, Craniectomy, or Both?

2002 • 49 citations

Anesthetic Choice of Halothane Versus Propofol

2001 • 46 citations

Perfusion- and diffusion-weighted magnetic resonance imaging for monitoring decompressive craniectomy in animals with experimental hemispheric stroke

2002 • 44 citations

MR angiographic investigation of transient focal cerebral ischemia in rat

2001 • 41 citations

Could Stroke Trials Be Missing Important Treatment Effects?

2002 • 40 citations

Characterization of neuronal cell death in normal and diabetic rats following exprimental focal cerebral ischemia

2001 • 38 citations

Genetic Aspects of Stroke: Human and Experimental Studies

2002 • 36 citations

Magnetic Resonance Angiography of Thromboembolic Stroke in Rats: Indicator of Recanalization Probability and Tissue Survival after Recombinant Tissue Plasminogen Activator Treatment

2002 • 35 citations

Filament size influences temperature changes and brain damage following middle cerebral artery occlusion in rats

2002 • 35 citations

Endothelin B receptor deficiency augments neuronal damage upon exposure to hypoxia–ischemia in vivo

2002 • 35 citations

Differential passage of [14C]sucrose and [3H]inulin across rat blood-brain barrier after cerebral ischemia

2001 • 32 citations

Menopause and ischaemic stroke: basic, clinical and epidemiological considerations. The role of hormone replacement

2002 • 28 citations

Physiologically Based Model of Acute Ischemic Stroke

2002 • 27 citations

The behavioural effect of middle cerebral artery occlusion on apolipoprotein-E deficient mice

2002 • 20 citations

Use of diffusion weighted MRI to predict the occurrence and severity of hemorrhagic transformation in a rabbit model of embolic stroke

2002 • 18 citations

Effects of endothelin-1 on blood-brain barrier permeability during focal cerebral ischemia in rats

2001 • 14 citations

Gene Expressions After Thrombolytic Treatment of Middle Cerebral Artery Clot Embolism in Mice

2001 • 13 citations

Postischemic Angiogenic Factor Expression in Stroke-Prone Rats

2002 • 11 citations

Acute ischemia causes 'dark cell' change of strial marginal cells in gerbil cochlea

2002 • 8 citations

New minimally invasive model of spinal cord ischemia in rats.

2002 • 8 citations

Genetic and gender determinants of cerebrovascular disease

2002 • 7 citations