Endothelin-1 and thromboxane A2 increase pulmonary vascular resistance in granulocyte-mediated lung injury

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils.

1976 • 734 citations

State of the Art

1983 • 655 citations

Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes.

1977 • 541 citations

Demonstration of a receptor on rabbit neutrophils for chemotactic peptides

1977 • 345 citations

Signal transduction and cytoskeletal activation in the neutrophil.

1987 • 282 citations

Physiological neutrophil sequestration in the lung: visual evidence for localization in capillaries

1987 • 178 citations

Discovery and Optimization of a Novel Class of Orally Active Nonpeptidic Endothelin-A Receptor Antagonists

1996 • 116 citations

Endothelin-1 in Adult Respiratory Distress Syndrome

1993 • 107 citations

Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET-1

1992 • 100 citations

Regional effects and clearance of endothelin‐1 across pulmonary and splanchnic circulation

1992 • 76 citations

Increased lung vascular permeability after arachidonic acid and hydrostatic challenge

1986 • 76 citations

Actions and interactions of mediator systems and mediators in the pathogenesis of ARDS and multiorgan failure

1991 • 50 citations

Endothelin‐1 does not mediate hypoxic vasoconstriction in canine isolated blood vessels: effect of BQ‐123

1993 • 50 citations

High yield enzymatic conversion of intravascular leukotriene A4 in blood-free perfused lungs.

1988 • 45 citations

Analysis of endothelin‐1‐induced contractions of guinea‐pig trachea, pulmonary veins and different types of pulmonary arteries

1990 • 42 citations

The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes.

1992 • 39 citations

Endothelin-A receptors mediate contraction in human cerebral, meningeal and temporal arteries

1994 • 38 citations

Augmented contractile response to endothelin and blunted endothelium-dependent relaxation in post-ischemic reperfused coronary arteries.

1992 • 31 citations

Inactivation of endothelin by polymorphonuclear leukocyte-derived lytic enzymes

1991 • 31 citations

Termination of second trimester pregnancy with laminaria and intramuscular 16 phenoxy-ω-17,18,19,20 tetranor PGE2 methylsuldonylamide (sulprostone) — A randomised study

1982 • 29 citations

Alterations of filtration coefficients in pulmonary edema of different pathogenesis

1992 • 25 citations

Human Polymorphonuclear Leukocytes Generate and Degrade Endothelin-1 by Two Distinct Neutral Proteases

1991 • 24 citations

Effect of allergen provocation on inflammatory cell profile and endothelin‐like immunoreactivity in guinea‐pig airways

1995 • 20 citations

Influence of the thromboxane antagonist BM 13.177 on the irrachidonic acid-induced increase in pulmonary vascular resistance and permeability in rabbit lungs

1985 • 17 citations

Human polymorphonuclear leukocytes have dual effects on endothelin-1: The induction of endothelin-1 mRNA expression in vascular endothelial cells and modification of the endothelin-1 molecule

1993 • 15 citations

Distribution of red and white blood cells in alveolar walls

1975 • 14 citations

A.340 Endothelin-induced effects on pulmonary vascular reaction and mediator release in the isolated rabbit lung

1996 • 1 citations