Distinct involvement of Cdc42 and RhoA GTPases in actin organization and cell shape in untransformed and Dbl oncogene transformed NIH3T3 cells

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Construction and applications of a highly transmissible murine retrovirus shuttle vector

1984 • 1,020 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases

1998 • 615 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

A role for Rho in Ras transformation.

1995 • 538 citations

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1989 • 529 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine

1997 • 492 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes

1985 • 426 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Effectors for the Rho GTPases

1999 • 327 citations

Introduction of macromolecules into cultured mammalian cells by osmotic lysis of pinocytic vesicles

1982 • 320 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

A Novel Regulator of p21-activated Kinases

1998 • 313 citations

Cdc42 Regulates Anchorage-Independent Growth and Is Necessary for Ras Transformation

1997 • 312 citations

Dbl family proteins

1997 • 260 citations

Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor κB by the Rho Family of GTPases

1998 • 233 citations

A novel Cdc42Hs mutant induces cellular transformation

1997 • 213 citations

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

1998 • 197 citations

Actin cytoskeleton organization in response to integrin-mediated adhesion

1999 • 159 citations

Cell surface molecules and fibronectin-mediated cell adhesion: effect of proteolytic digestion of membrane proteins.

1982 • 127 citations

Requirement for Rho in Integrin Signalling

1997 • 127 citations

Characterization and expression of the human rhoH12 gene product.

1989 • 108 citations

Citron Rho-interacting Kinase, a Novel Tissue-specific Ser/Thr Kinase Encompassing the Rho-Rac-binding Protein Citron

1998 • 105 citations

Guanine Nucleotide Exchange Factors Regulate Specificity of Downstream Signaling from Rac and Cdc42

1998 • 81 citations

[20] Purification and assay of recombinant C3 transferase

1995 • 62 citations

Transformation Activity of Cdc42 Requires a Region Unique to Rho-related Proteins

1998 • 46 citations

Integrin-dependent Tyrosine Phosphorylation and Growth Regulation by Vav

1999 • 34 citations

Actin cytoskeleton polymerization in Dbl-transformed NIH3T3 fibroblasts is dependent on cell adhesion to specific extracellular matrix proteins

1997 • 19 citations

Characterization and Expression of the Human rhoH12 Gene Product

1989 • 17 citations

[38] Cell transformation by dbl oncogene

1995 • 8 citations