Drug Tolerance and Sensitization: A PHARMACOLOGICALOVERVIEW

A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8.

1957 • 1,671 citations

Tolerance to, and dependence on, some non-opiate psychotropic drugs.

1971 • 761 citations

Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats

1973 • 523 citations

Alcohol Dependence Produced in Mice by Inhalation of Ethanol: Grading the Withdrawal Reaction

1971 • 437 citations

Behavioral variables affecting the development of amphetamine tolerance

1966 • 302 citations

Increase of ?antianxiety? activity and tolerance of behavioral depression during chronic administration of oxazepam

1968 • 232 citations

Formulation of a Morphine Implantation Pellet Suitable for Tolerance-Physical Dependence Studies in Mice

1970 • 223 citations

Ethanol Tolerance in the Rat Is Learned

1981 • 123 citations

Behavioural tolerance to amphetamine and other psychostimulants: The case for considering behavioural mechanisms

1983 • 117 citations

Effects of ethanol and pentobarbital on release of acetylcholine from cerebral cortex slices.

1967 • 114 citations

The temperature response in rats during acute and chronic morphine administration, a study of morphine tolerance.

1960 • 97 citations

Tolerance to and cross-tolerance among ethanol, pentobarbital and chlordiazepoxide

1986 • 84 citations

A technique for accurate measurement of moderate degrees of alcohol intoxication in small animals.

1968 • 83 citations

7 Alcohol and neurotransmitters

1978 • 67 citations

Monoclonal antibodies for studies on xenobiotic and endobiotic metabolism

1985 • 61 citations

Biochemical and behavioral effects of acute ethanol in rats at different environmental temperatures

1981 • 59 citations

Quantitative assessment of tolerance to and dependence on morphine in mice

1977 • 56 citations

Effects of convulsant and narcotic drugs on acetylcholine synthesis.

1951 • 50 citations

Tolerance to ethanol and cross-tolerance to pentobarbital and barbital

1986 • 46 citations

Genetics of Alcoholism and Alcohol Actions

1984 • 44 citations

Effects of chronically administered d-amphetamine on spaced responding maintained under multiple and single-component schedules

1986 • 41 citations

Pharmacogenetic tools in the study of drug tolerance and dependence.

1980 • 40 citations

Effects of frontal polar cortical ablation and cycloheximide on ethanol tolerance in rats

1976 • 37 citations

Electrophysiological effects of ethanol on the nervous system

1981 • 32 citations

Consequent events as determinants of drug effects on schedule-controlled behavior: modification of effects of cocaine and d-amphetamine following chronic amphetamine administration.

1979 • 29 citations

Influence of ambient temperature on the development and maintenance of tolerance to ethanol-induced hypothermia

1986 • 28 citations

ELECTROENCEPHALOGRAPHIC AND OTHER EVIDENCE FOR MIXED DEPRESSANT AND STIMULANT ACTIONS OF ALCOHOLIC BEVERAGES

1973 • 26 citations

Tolerance to hypothermia induced by ethanol depends on specific drug effects

1986 • 26 citations

Log dose/response curve flattening in rats after daily injection of opiates

1980 • 23 citations

Learned and pharmacologically-induced tolerance to ethanol and cross-tolerance to morphine and clonidine

1986 • 23 citations

Tolerance to hyperthermia produced by morphine in rat

1987 • 21 citations

An analysis of cross-tolerance among ethanol, other general depressants and opioids.

1982 • 20 citations

Ethanol Withdrawal: Altered Ambient Temperature Selection in Rats

1977 • 17 citations

Development and reacquisition of tolerance to ethanol administered pre- and post-trial to rats

1981 • 16 citations

Rapid adaptation to neuronal membrane effects of ethanol and low temperature: Some speculations on mechanism

1979 • 15 citations

Stimulation is necessary for the development of tolerance to a neuronal effect of ethanol

1980 • 14 citations

Role of alcohol P-450-oxygenase (APO) in microsomal ethanol oxidation

1985 • 12 citations

Chronic Effects of Alcohols on Mouse Biomembranes

1980 • 10 citations