Genetics of Alcoholism and Alcohol Actions

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

The pharmacological basis of therapeutics

1981 • 2,853 citations

Introduction to Quantitative Genetics.

1961 • 1,942 citations

Inheritance of Alcohol Abuse

1981 • 1,873 citations

Introduction to Quantitative Genetics.

1960 • 1,647 citations

Alcohol Problems in Adoptees Raised Apart From Alcoholic Biological Parents

1973 • 895 citations

The familial incidence of alcoholism: a review.

1979 • 817 citations

Biometrical Genetics

1971 • 719 citations

RECOMBINANT-INBRED STRAINS AN AID TO FINDING IDENTITY, LINKAGE, AND FUNCTION OF HISTOCOMPATIBILITY AND OTHER GENES

1971 • 595 citations

High Blood Acetaldehyde Levels after Ethanol Administration

1975 • 514 citations

Drinking Problems in Adopted and Nonadopted Sons of Alcoholics

1974 • 514 citations

Maternal Inheritance of Alcohol Abuse

1981 • 468 citations

Evidence of Genetic Predisposition to Alcoholic Cirrhosis and Psychosis: Twin Concordances for Alcoholism and Its Biological End Points by Zygosity among Male Veterans

1981 • 459 citations

Differences in Alcohol Preference among Inbred Strains of Mice

1959 • 453 citations

Frontiers in Catecholamine Research

1976 • 451 citations

Genetic Selection for Voluntary Alcohol Consumption in the Albino Rat

1968 • 450 citations

Abnormality of a Thiamine-Requiring Enzyme in Patients with Wernicke-Korsakoff Syndrome

1977 • 397 citations

Modern problems of pharmacopsychiatry

1969 • 393 citations

Developmental changes and polymorphism in human alcohol dehydrogenase

1971 • 375 citations

Ethnic Differences in Alcohol Sensitivity

1972 • 373 citations

Alcoholism

1970 • 313 citations

A Study of Alcoholism in Half Siblings

1972 • 304 citations

Self-rating of alcohol intoxication by young men with and without family histories of alcoholism.

1980 • 258 citations

ANIMAL MODELS IN ALCOHOL RESEARCH

1979 • 255 citations

Development of Alcoholism in Adoptees Raised Apart From Alcoholic Biologic Relatives

1980 • 244 citations

Biological Basis of Alcoholism

1972 • 241 citations

Alcohol and Aldehyde Metabolizing Systems-IV

1980 • 241 citations

Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication.

1980 • 236 citations

Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preference

1973 • 229 citations

Ethanol Ingestion: Differences in Blood Acetaldehyde Concentrations in Relatives of Alcoholics and Controls

1979 • 225 citations

Relationship between facial flushing and blood acetaldehyde levels after alcohol intake

1979 • 221 citations

Genetic and environmental factors affecting ethanol metabolism in man

1971 • 207 citations

Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats

1982 • 201 citations

AN ATYPICAL HUMAN ALCOHOL DEHYDROGENASE

1965 • 191 citations

Alcohol Sensitivity and Ethnic Background

1974 • 190 citations

The EEG After Alcohol Administration in Men at Risk for Alcoholism

1983 • 185 citations

Inheritance of Alcoholism in Adoptees

1978 • 185 citations

Electroencephalograms in Children of Alcoholic Fathers

1982 • 179 citations

A comparison of the effects of alcohol on mice selectively bred for differences in ethanol sleep-time

1974 • 175 citations

Effect of impulse flow on the release and synthesis of dopamine in the striatum

1973 • 174 citations

Different sensitivities to ethanol in alcohol-preferring and -nonpreferring rats

1982 • 172 citations

Alcoholism in Twins. Studies on the Etiology and Sequels of Abuse of Alcohol

1961 • 167 citations

Psychopathology in Adopted and Nonadopted Daughters of Alcoholics

1977 • 164 citations

Brain Sensitivity to Alcohol in Inbred Mouse Strains

1966 • 162 citations

Racial Differences in Biological Sensitivity to Ethanol: The Role of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Isozymes

1981 • 160 citations

Electrophoretic and biochemical studies of human aldehyde dehydrogenase isozymes in various tissues

1980 • 159 citations

Vasomotor sensitivity to alcohol in diverse Mongoloid populations.

1973 • 157 citations

The incidence of rare alleles determining electrophoretic variants: data on 43 enzyme loci in man

1974 • 154 citations

Platelet and Plasma Amine Oxidase Activity in Alcoholic Individuals

1978 • 150 citations

Aldehyde Dehydrogenase and Ethanol Preference in Mice

1970 • 145 citations

The kinetics of ethanol absorption and elimination in twins and supplementary repetitive experiments in singleton subjects

1977 • 145 citations

Effect of hypnotics on mice genetically selected for sensitivity to ethanol

1976 • 145 citations

Alcohol and Aldehyde Metabolizing Systems

1977 • 138 citations

Isolation of II-alcohol dehydrogenase of human liver: Is it a determinant of alcoholism?

1977 • 136 citations

Alcohol's effect on body temperature: Hypothermia, hyperthermia or poikilothermia?

1981 • 130 citations

Genetic differences in ethanol drinking of the rat following injection of 6-OHDA, 5,6-DHT or 5,7-DHT into the cerebral ventricles

1976 • 125 citations

Enzymology of Human Alcohol Metabolism

1977 • 125 citations

Is Alcoholism Hereditary?

1971 • 125 citations

The effects of 6-hydroxydopamine on tolerance to and dependence on ethanol.

1977 • 125 citations

Genetic control of ethanol action on the central nervous system

1977 • 123 citations

Differential actions on voluntary alcohol intake of tetrahydroisoquinolines or a β-carboline infused chronically in the ventricle of the rat

1977 • 122 citations

Polygenic and single-gene determination of responses to ethanol in BXD/Ty recombinant inbred mouse strains.

1983 • 118 citations

ATYPICAL HUMAN LIVER ALCOHOL DEHYDROGENASE

1968 • 116 citations

Gamma hydroxybutyrate

1977 • 115 citations

Sensitivity to ethanol in inbred mice: Genotypic correlations among several behavioral responses.

1983 • 115 citations

Electrophysiological Correlates of Ethanol-Induced Sedation in Differentially Sensitive Lines of Mice

1980 • 115 citations

Human liver .pi.-Alcohol dehydrogenase: kinetic and molecular properties

1979 • 114 citations

Inheritance of Drinking Behavior: A Study on Intelligence, Personality, and Use of Alcohol of Adult Twins.

1967 • 112 citations

Mouse Strain Differences in Preference for Various Concentrations of Alcohol

1962 • 111 citations

EFFECT OF IMPULSE FLOW ON THE RELEASE AND SYNTHESIS OF DOPAMINE IN THE RAT STRIATUM

1973 • 110 citations

Alcohol and acetaldehyde metabolism in Caucasians, Chinese and Amerinds.

1976 • 109 citations

Introduction to behavioral genetics

1974 • 108 citations

Introduction to behavioral genetics

1973 • 107 citations

Genetic Aspects of Increase in Rat Liver Aldehyde Dehydrogenase Induced by Phenobarbital

1971 • 105 citations

Characterization of Acute and Chronic Tolerance in Mice Selected for Inherent Differences in Sensitivity to Ethanol

1980 • 104 citations

Sensitivity to ethanol in inbred mice: Genotypic correlations among several behavioral responses.

1983 • 103 citations

Measurement of alcohol preference in genetic experiments.

1964 • 101 citations

Genetic correlations with ethanol withdrawal severity

1983 • 101 citations

Alcohol preference as a function of its caloric utility in mice.

1963 • 99 citations

Enzyme activities and ethanol preference in mice

1968 • 98 citations

Tolerance to Ethanol Hypothermia in Inbred Mice: Genotypic Correlations with Behavioral Responses

1982 • 97 citations

Ethanol disordering of spin-labeled mouse brain membranes: correlation with genetically determined ethanol sensitivity of mice.

1982 • 96 citations

Inherited Differences in Intensity of Alcohol Withdrawal Reactions in Mice

1973 • 95 citations

Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats

1978 • 92 citations

Induction of different rat liver supernatant aldehyde dehydrogenases by phenobarbital and tetrachlorodibenzo-p-dioxin.

1977 • 92 citations

Preabsorptive vs. postabsorptive control of ethanol intake in C57BL/6J and DBA/2J mice

1977 • 91 citations

Blood Alcohol Level Discrimination

1980 • 91 citations

Acute tolerance in inbred and selected lines of mice

1979 • 91 citations

Genetic selection for ethanol withdrawal severity: Differences in replicate mouse lines

1983 • 89 citations

Human liver aldehyde dehydrogenase in Chinese and Asiatic Indians: Gene deletion and its possible implications in alcohol metabolism

1981 • 87 citations

Evidence for genetic correlation of hypnotic effects and cerebellar Purkinje neuron depression in response to ethanol in mice

1982 • 86 citations

Ethanol metabolism in subiects possessing typical and atypical liver alcohol dehydrogenase

1967 • 84 citations

The determination of acetaldehyde in human blood by the perchloric acid precipitation method: The characterization and elimination of artefactual acetaldehyde formation

1982 • 81 citations

Ethanol metabolism in Peromyscus genetically deficient in alcohol dehydrogenase

1980 • 77 citations

Rat strains specially selected for their voluntary alcohol consumption.

1971 • 75 citations

ATYPICAL HUMAN LIVER ALCOHOL DEHYDROGENASE

1968 • 73 citations

Sensitivity to low doses of ethanol and pentobarbital in mice selected for sensitivity to hypnotic doses of ethanol.

1976 • 72 citations

Parent and offspring alcohol use; imitative and aversive transmission.

1982 • 71 citations

Ethanol-induced mouse strain differences in locomotor activity

1975 • 69 citations

Ethanol-induced depressions in cerebellar and hippocampal neurons of mice selectively bred for differences in ethanol sensitivity: An electrophysiological study

1981 • 68 citations

Human liver alcohol dehydrogenase isoenzyme variations

1978 • 68 citations

Ethanol preference and behavioral tolerance in mice: Biochemical and neurophysiological mechanisms.

1973 • 66 citations

Interrelationships of alcohol consumption, actions of alcohol, and biochemical traits

1980 • 66 citations

Selective breeding of rats for differences in reactivity to alcohol. An approach to an animal model of alcoholism. II. Behavioral measures.

1977 • 65 citations

Differential effects of ethanol and pentobarbital on sleep time in C57BL and BALB mice.

1974 • 62 citations

Ethanol-induced hypothermia in mice: Influence of genotype on development of tolerance

1978 • 61 citations

Drugs and the Inheritance of Behavior

1978 • 59 citations

Alcohol withdrawal reactions and reserpine effects in inbred strains of mice

1974 • 58 citations

Differences in muscle-tension response to ethanol in young men with and without family histories of alcoholism.

1981 • 57 citations

Age and strain differences in the rate of development of functional tolerance to ethanol by mice

1979 • 55 citations

Alcohol-induced conditioned aversion: Genotypic specificity in mice (Mus musculus).

1975 • 54 citations

Role of liver cytosolic aldehyde dehydrogenase isozymes in control of blood acetaldehyde concentrations.

1977 • 54 citations

Differential effects of pentobarbital and ethanol in mice

1976 • 53 citations

Differential sensitivity of cerebellar purkinje neurons to ethanol in selectivity outbred lines of mice: maintenance in vitro independent of synaptic transmission

1983 • 53 citations

Effects of gamma-butyrolactone, amphetamine, and haloperidol in mice differing in sensitivity to alcohol

1980 • 50 citations

Platelet Monoamine Oxidase Activity in Relatives of Alcoholics

1982 • 50 citations

A comparative study of the acute effects of ethanol on the cholinergic system in hippocampus and striatum of inbred mouse strains.

1982 • 49 citations

Genetic influences on the rate of development of ethanol tolerance and the ethanol physical withdrawal syndrome in mice

1979 • 48 citations

Heritability of Alcohol Preference in Laboratory Mice and Rats

1970 • 48 citations

Factors involved in ethanol narcosis: Analysis in mice of three inbred strains

1973 • 48 citations

AN ANALYSIS OF ALCOHOL‐RELATED QUESTIONNAIRE ITEMS FROM THE NATIONAL MERIT TWIN STUDY

1972 • 47 citations

ANAESTHETIC REQUIREMENT IN MICE SELECTIVELY BRED FOR DIFFERENCES IN ETHANOL SENSITIVITY

1981 • 47 citations

The effect of halothane on mice selectively bred for differential sensitivity to alcohol

1980 • 47 citations

Motor activity and alcohol: Genetic analysis in the mouse

1976 • 46 citations

Selective breeding of rats for differences in reactivity to alcohol. An approach to an animal model of alcoholism. I. General procedures.

1976 • 46 citations

Brain and liver aldehyde dehydrogenase: Relations to ethanol consumption in wistar rats

1977 • 44 citations

Differential ethanol sensitivity of intraocular cerebellar grafts in long-sleep and short-sleep mice.

1982 • 44 citations

Adrenocortical function in mice selectively bred for different sensitivity to ethanol

1976 • 44 citations

Brain and liver aldehyde dehydrogenase activity and voluntary ethanol consumption by rats: Relations to strain, sex, and age

1978 • 43 citations

Genetic Differences in the Susceptibility to Acute Ethanol Intoxication in Selected Rat Strains

1977 • 43 citations

Neurochemical correlates of alcohol preference in inbred strains of mice

1975 • 43 citations

Peak Blood Alcohol Levels in Men at High Risk for the Future Development of Alcoholism

1981 • 43 citations

Correlation between human erythrocyte aldehyde dehydrogenase activity and sensitivity to alcohol

1980 • 42 citations

Circadian and Genetic Effects on Ethanol Elimination in LS and SS Mice

1982 • 42 citations

MECHANISMS THAT UNDERLIE SEX‐LINKED AND GENOTYPICALLY DETERMINED DIFFERENCES IN THE DEPRESSANT ACTIONS OF ALCOHOL*

1976 • 42 citations

Mediation of myoclonic seizures by dopamine and clonic seizures by acetylcholine and gaba

1977 • 42 citations

Nonlinear Pharmacokinetics of Ethanol Elimination in Long Sleep and Short Sleep Mice

1983 • 41 citations

Behavior-genetic-dependent self-selection of alcohol in rats.

1972 • 41 citations

Genetics and ethanol tolerance

1979 • 40 citations

Swift increase in alcohol metabolism (SIAM) in the mouse: comparison of the effect of short-term ethanol treatment on ethanol elimination in four inbred strains.

1982 • 40 citations

Investigations into the neurochemical mechanisms mediating differences in ethanol sensitivity in two lines of mice.

1982 • 40 citations

Alcohol selection by strains of rats selectively bred for behavior.

1979 • 40 citations

Lack of difference in blood acetaldehyde of alcoholics and controls after ethanol ingestion

1980 • 38 citations

Liver alcohol dehydrogenase in a Japanese population.

1972 • 38 citations

Effects of pentobarbital in mice selected for differential sensitivity to ethanol

1982 • 38 citations

SELECTIVE BREEDING OF RATS FOR DIFFERENCES IN REACTIVITY TO ALCOHOL: AN APPROACH TO AN ANIMAL MODEL OF ALCOHOLISM

1977 • 38 citations

ETHANOL CONSUMPTION AND PREFERENCE IN MICE: A GENETIC ANALYSIS

1972 • 38 citations

Brain neurotransmitter receptor systems in mice genetically selected for differences in sensitivity to ethanol

1980 • 37 citations

Gamma aminobutyric acid in different strains of mice effect of ethanol

1976 • 37 citations

Ethanol sleep times and hepatic alcohol and aldehyde dehydrogenase activities in mice

1972 • 37 citations

FAMILY HISTORY AND HALF‐SIBLING RESEARCH IN ALCOHOLISM*

1972 • 35 citations

ALCOHOL METABOLISM OF INBRED STRAINS OF RATS WITH ALCOHOL PREFERENCE AND NONPREFERENCE

1977 • 34 citations

The ethanol stimulus in rats with differing ethanol preferences

1981 • 33 citations

Alcohol intoxication and withdrawal in inbred strains of mice: Behavioral and endocrine studies

1979 • 33 citations

Three heritable responses to alcohol in a heterogeneous randomly mated mouse strain. Inferences for humans.

1977 • 32 citations

Rapidly developing functional tolerance to ethanol is accompanied by increased erythrocyte cholesterol in mice.

1982 • 32 citations

Familial resemblances in flushing following alcohol use

1982 • 31 citations

Ethanol consumption: Selective breeding in mice

1981 • 31 citations

Strain-specific effects of ethanol on open field activity in inbred mice.

1980 • 28 citations

Alcohol intake in selected lines of mice: Importance of sex and genotype.

1979 • 28 citations

Ethanol selection by inbred mice. Mode of inheritance and the effect of age on the genetic system.

1978 • 28 citations

Pink Spot and DMPEA

1971 • 27 citations

Concentration‐Dependent Effects of Ethanol in Long‐Sleep and Short‐Sleep Mice

1983 • 27 citations

Effects of Ethanol on Urinary Arginine Vasopressin Excretion in Two Rat Strains Selected for Their Different Ethanol Preferences

1977 • 26 citations

Lipid solubility is correlated with hypnotic and hypothermic responses of long-sleep (LS) and short-sleep (SS) mice to various depressant drugs.

1983 • 26 citations

Alcohol elimination rates in adoptees with and without alcoholic parents.

1977 • 25 citations

Genetic Analysis of Ethanol Preference in Rats Selected for Emotional Reactivity

1968 • 25 citations

Use of genetic to test the potential role of serotonin in alcohol preference

1975 • 25 citations

Differential induction of hepatic microsomal ethanol and drug metabolism by 3-methylcholanthrene in "LS" and "SS" mice.

1979 • 24 citations

Dietary tryptophan and the selection of ethyl alcohol in different strains of rats

1975 • 24 citations

Selective breeding in mice for severity of the ethanol withdrawal syndrome.

1982 • 24 citations

Behavioral effects of salsolinol and ethanol on mice selected for sensitivity to alcohol-induced sleep time

1977 • 24 citations

Brain aldehyde dehydrogenase activity in rat strains with high and low ethanol preferences

1981 • 24 citations

Renin, Water drinking, salt preference and blood pressure in alcohol preferring and alcohol avoiding rats

1980 • 22 citations

Acute ethanol effects on blood pH, PCO2, and PO2 in LS and SS mice

1982 • 22 citations

Ethanol-induced changes in tyrosine hydroxylase activity in brains of mice selectively bred for differences in sensitivity to ethanol

1981 • 21 citations

Withdrawal-like signs induced by a single administration of ethanol in mice that differ in ethanol sensitivity

1980 • 20 citations

Alcohol Metabolism and Sensitivity Reactions Among the Reddis of South India

1978 • 20 citations

The estimation of heritability for the self-selection of alcohol in the albino rat.

1969 • 20 citations

Task-dependent genetic influences on behavioral response of mice (Mus musculus) to acetaldehyde.

1978 • 19 citations

Genetic analysis of tolerance to ethanol hypothermia in recombinant inbred mice: Effect of desglycinamide(9)-Arginine(8)-vasopressin

1980 • 19 citations

Genetic differences in tolerance to ethanol: A study in UChA and UChB rats

1981 • 18 citations

Ethanol consumption and hepatic enzyme activity

1979 • 18 citations

Individual Differences in Blood and Breath Acetaldehyde Levels and Urinary Excretion of Catecholamines After Alcohol Intake

1980 • 18 citations

Cerebellar role in the differential ethanol sensitivity of long sleep and short sleep mice

1983 • 17 citations

Selective Breeding for a Multivariate Index of Ethanol Dependence in Mice: Results from the First Five Generations

1983 • 16 citations

The Effects of Chronic Ethanol Ingestion on Ethanol Binding to Hepatic Cytochrome P‐450 and on Certain Hepatic and Renal Parameters in the “Long Sleep” and “Short Sleep” Mouse

1981 • 16 citations

Fertility and offspring survival in mice selected for different sensitivities to alcohol

1977 • 16 citations

Recombinant Inbred Strains: A Novel Genetic Approach for Psychopharmacogeneticists

1975 • 16 citations

Genetics and psychopharmacology

1975 • 15 citations

A simplified triple-test cross analysis of alcohol preference in the rat

1981 • 15 citations

Dissociation between the anticonvulsant action of alcohol and its depressant action in mice of different genotypes

1978 • 13 citations

Ethanol-induced conditioned taste aversions in mice that differ in neural sensitivity to ethanol.

1982 • 13 citations

Electrical stimulation and lesions of the medial forebrain bundle of the rat: Changes in voluntary ethanol consumption and brain aldehyde dehydrogenase activity

1978 • 13 citations

Alcoholism: a pharmacogenetic disorder.

1975 • 12 citations

Lack of association between preference for and dependence on ethanol

1982 • 11 citations

Morphine withdrawal in mice selectively bred for differential sensitivity to ethanol

1982 • 11 citations

Avoidance behavior in rats selectively bred for differential alcohol sensitivity

1980 • 10 citations

Differential neurosensitivity to three alcohols and phenobarbital in C57BL/6J and DBA/2J mice

1982 • 10 citations

Hypnotic susceptibility to various depressants in rats selected for differential ethanol sensitivity

1979 • 10 citations

Genetic influences on alcohol consumption and actions of alcohol.

1981 • 10 citations

Additive effects of ethanol and purkinje cell loss in the production of ataxia in mice

1976 • 10 citations

Neonatal cerebellectomy alters ethanol-induced sleep time of short sleep but not long sleep mice

1984 • 10 citations

Dissociation of Components of Ethanol Intoxication and Tolerance

1982 • 9 citations

Psychophysiologic test performance in normal twins and in a pair of identical twins with essential tremor that is suppressed by alcohol

1977 • 9 citations

The genetics of alcohol preference in the female rat confirmed by a full triple-test cross

1983 • 9 citations

Suppression of alcohol-induced flushing by a combination of H1 and H2 histamine antagonists

1982 • 8 citations

ALCOHOL METABOLISM AND ALCOHOLISM—PHARMACOGENETIC CONSIDERATIONS

1980 • 8 citations

Dopamine-β-hydroxylase activity and ethanol-induced sleep time in selectively bred and heterogeneous stock mice

1982 • 7 citations

Untersuchungen Über die Alkoholblutkonzentration nach Alkoholgaben bei 10 eineiigen und 10 zweieiigen Zwillingspaaren

1939 • 7 citations

The Genetics of Human Alcoholism: A Review

1981 • 7 citations

Ethanol Elimination is Inherited in the Rat

1980 • 7 citations

Genetic analysis of sensitivity to ethanol-induced depression of motor activity and impairment of swimming in rats

1983 • 6 citations

Task-dependent ethanol effects on escape in rats bred for ethanol sensitivity

1981 • 6 citations

Urine sodium, potassium and osmolality in two rat strains selected for their different ethanol preferences.

1976 • 6 citations

Heritability of alcohol preference in laboratory mice and rats: Erroneous estimates

1982 • 5 citations

Genotypic-dependent amphetamine effects in rats bred for differences in alcohol sensitivity

1979 • 4 citations

Genetic and ethanol‐related differences in maternal behavior and offspring viability in mice

1979 • 3 citations

More on the heritability of alcohol preference in laboratory mice and rats

1983 • 3 citations

Peak ethanol withdrawal convulsions in genetically selected mice.

1983 • 3 citations