Log dose/response curve flattening in rats after daily injection of opiates

Central nervous system mechanisms of analgesia

1976 • 710 citations

Simultaneous quantitative assessment of morphine tolerance and physical dependence.

1969 • 681 citations

Tolerance to and physical dependence on morphine in rats

1963 • 446 citations

Morphine Analgesic Tolerance: Its Situation Specificity Supports a Pavlovian Conditioning Model

1976 • 320 citations

Antinociceptive activity of narcotic agonist and partial agonist analgesics and other agents in the tail-immersion test in mice and rats

1976 • 235 citations

PHYSIOLOGICAL PHARMACOLOGY

1963 • 227 citations

Tolerance to the hyperthermic effect of morphine in the rat is a learned response.

1978 • 201 citations

Physiological Aspects of Tolerance and Physical Dependence

1963 • 196 citations

Principles of Drug Action

1995 • 170 citations

Morphine pellet implantation in rats: quantitative assessment of tolerance and dependence.

1973 • 146 citations

A COMPARISON BETWEEN ACUTE AND CHRONIC PHYSICAL DEPENDENCE IN THE CHRONIC SPINAL DOG.

1964 • 130 citations

ACUTE TOLERANCE TO NARCOTIC ANALGESIC DRUGS IN RATS

1968 • 116 citations

The temperature response in rats during acute and chronic morphine administration, a study of morphine tolerance.

1960 • 97 citations

Selective release of histamine from rat mast cells by several drugs.

1970 • 83 citations

Quantitative relationships among measures of morphine tolerance and physical dependence in the rat

1979 • 82 citations

Effects of morphine on the turnover of brain catecholamines and serotonin in rats — acute morphine administration

1975 • 69 citations

Accelerated development of tolerance during repeated cycles of ethanol exposure

1978 • 61 citations

Quantitative assessment of tolerance to and dependence on morphine in mice

1977 • 56 citations

Changes in the hyperthermic responses of rats to daily injections of morphine and the antagonism of the acute response by naloxone

1978 • 56 citations

The development of tolerance to morphine in the rat

1977 • 55 citations

Single-dose tolerance to morphine hypothermia in the rat: differentiation of acute from long-term tolerance.

1977 • 50 citations

THE OFFSET OF MORPHINE TOLERANCE IN RATS AND MICE

1975 • 45 citations

Tolerance to the stimulant effects of morphine and pentazocine on avoidance responding in the rat

1974 • 36 citations

Non-competitive nature of the antagonistic mechanism responsible for tolerance development to opiate-induced analgesia

1979 • 36 citations

Effects of endorphin and enkephalin analogs on fear habituation in goldfish

1978 • 34 citations

Effects of morphine on the turnover of brain catecholamines and serotonin in rats — chronic morphine administration

1975 • 33 citations

Comparison of effect of morphine‐like analgesics on transmurally stimulated guinea‐pig ileum

1969 • 31 citations

Tolerance to morphine analgesia and immobility measured in rats by changes in log-dose-response curves

1978 • 25 citations

In vivo receptor occupation by opiates and correlation to the pharmacological effect.

1978 • 23 citations

Tolerance to morphine.

1972 • 22 citations

THE ROLE OF SUPERSENSITIVITY TO ACETYLCHOLINE IN THE PRODUCTION OF TOLERANCE TO MORPHINE IN STIMULATED GUINEA‐PIG ILEUM

1974 • 20 citations

Effect of stimulus intensity on the potency of some analgetic agents.

1973 • 19 citations

Cataleptic Effect of 61-91 Beta-Lipotropic Hormone in Rat

1977 • 19 citations

Development of tolerance to the stimulatory effect of morphine in dog intestine

1974 • 11 citations

Time course of etorphine levels in tissues of opiate tolerant and nontolerant rats.

1979 • 10 citations

The effect of thiazol-4-ylmethoxyamine, a histidine decarboxylase inhibitor, on the development of morphine tolerance and physical dependance in mice

1976 • 7 citations

Aspects of Pharmacokinetics of Opiates

1973 • 2 citations