Discrete domains of human U6 snRNA required for the assembly of U4/U6 snRNP and splicing complexes.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Direct chemical method for sequencing RNA.

1979 • 940 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

1987 • 530 citations

Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs

1986 • 490 citations

SPLICEOSOMAL snRNAs

1988 • 463 citations

Spliceosomal RNA U6 is remarkably conserved from yeast to mammals

1988 • 428 citations

[9] Specific labeling of 3′ termini of RNA with T4 RNA ligase

1980 • 421 citations

Spliceosome assembly in yeast.

1987 • 402 citations

Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes

1986 • 283 citations

An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly.

1987 • 272 citations

U6 small nuclear RNA is transcribed by RNA polymerase III.

1986 • 250 citations

Structure and function of major and minor small nuclear ribonucleoprotein particles

1989 • 242 citations

U4 and U6 RNAs coexist in a single small nuclear ribonucleoprotein particle

1984 • 238 citations

Cryptic branch point activation allows accurate in vitro splicing of human β-globin intron mutants

1985 • 236 citations

Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing.

1984 • 213 citations

Trans splicing of mRNA precursors

1985 • 205 citations

Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.

1988 • 188 citations

Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles.

1988 • 183 citations

Splice site selection and ribonucleoprotein complex assembly during in vitro pre-mRNA splicing.

1988 • 163 citations

Localization of a base-paired interaction between small nuclear RNAs U4 and U6 in intact U4/U6 ribonucleoprotein particles by psoralen cross-linking

1985 • 137 citations

Gel Electrophoretic Isolation of Splicing Complexes Containing U1 Small Nuclear Ribonucleoprotein Particles

1988 • 95 citations

Ribonucleoprotein Complex Formation During Pre-mRNA Splicing in Vitro

1986 • 93 citations

Analysis of mRNA 3′ end formation by modification interference: the only modifications which prevent processing lie in AAUAAA and the poly(A) site.

1987 • 77 citations

In vitro reconstitution of snRNPs: a reconstituted U4/U6 snRNP participates in splicing complex formation.

1989 • 40 citations

A chemical modification/interference study of yeast pre-mRNA spliceosome assembly and splicing.

1988 • 39 citations

C.eleganssnRNAs: a model for U4/U6 base paising

1988 • 18 citations