The process of malignant progression in human breast cancer

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Adenocarcinoma of the Vagina

1971 • 2,464 citations

A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2

1973 • 2,431 citations

ON THE TREATMENT OF INOPERABLE CASES OF CARCINOMA OF THE MAMMA: SUGGESTIONS FOR A NEW METHOD OF TREATMENT, WITH ILLUSTRATIVE CASES.

1896 • 1,633 citations

ON THE TREATMENT OF INOPERABLE CASES OF CARCINOMA OF THE MAMMA: SUGGESTIONS FOR A NEW METHOD OF TREATMENT, WITH ILLUSTRATIVE CASES.1

1896 • 1,240 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 • 881 citations

The Biology of Cancer Invasion and Metastasis

1978 • 819 citations

Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice.

1990 • 617 citations

Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.

1987 • 508 citations

Cancer of the Breast

1980 • 469 citations

Expression of Transforming Growth Factor α and its Messenger Ribonucleic Acid in Human Breast Cancer: Its Regulation by Estrogen and its Possible Functional Significance

1988 • 440 citations

Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens.

1987 • 413 citations

Human breast carcinoma cells in continuous culture: a review.

1978 • 345 citations

Steroid-hormone receptors in breast cancer

1984 • 327 citations

Tumor invasion and metastases: role of the basement membrane. Warner-Lambert Parke-Davis Award lecture.

1984 • 321 citations

Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms.

1981 • 291 citations

Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen receptor and progestin receptor levels.

1984 • 279 citations

Estrogen-Induced Factors of Breast Cancer Cells Partially Replace Estrogen to Promote Tumor Growth

1986 • 273 citations

Cancer of the Breast

1980 • 263 citations

Steroid receptors and other prognostic factors in primary breast cancer.

1988 • 227 citations

Basement Membrane and the Invasive Activity of Metastatic Tumor Cells

1986 • 209 citations

Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer.

1988 • 208 citations

Antiestrogens inhibit the mitogenic effect of growth factors on breast cancer cells in the total absence of estrogens

1987 • 205 citations

Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo.

1989 • 182 citations

Do hormones cause breast cancer?

1984 • 162 citations

Multihormonal Regulation of Insulin-Like Growth Factor-I-Related Protein in MCF-7 Human Breast Cancer Cells

1988 • 161 citations

Estrogen receptor content and hormone-responsive growth of mouse mammary tumors.

1974 • 150 citations

A Multidrug-Resistant MCF-7 Human Breast Cancer Cell Line Which Exhibits Cross-Resistance to Antiestrogens and Hormone-Independent Tumor Growthin Vivo

1988 • 149 citations

Effects of serum and insulin on the sensitivity of the human breast cancer cell line MCF-7 to estrogen and antiestrogens.

1981 • 138 citations

Triphenylethylenes: A New Class of Protein Kinase C Inhibitors

1986 • 138 citations

The Effects of a Constitutive Expression of Transforming Growth Factor-α on the Growth of MCF-7 Human Breast Cancer Cellsin Vitroandin Vivo

1989 • 132 citations

Selection and Characterization of a Breast Cancer Cell Line Resistant to the Antiestrogen LY 117018

1985 • 130 citations

Clonal variation of MCF-7 breast cancer cells in vitro and in athymic nude mice.

1983 • 118 citations

Immunological detection and quantitation of alpha transforming growth factors in human breast carcinoma cells

1986 • 114 citations

Antiestrogen action in breast cancer cells: Modulation of proliferation and protein synthesis, and interaction with estrogen receptors and additional antiestrogen binding sites

1985 • 113 citations

An antiestrogen-binding protein in human tissues.

1983 • 96 citations

Estrogen receptors and long-term prognosis in breast cancer

1984 • 90 citations

Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells.

1986 • 87 citations

Therapeutic implications of tumor heterogeneity.

1989 • 83 citations

UICC multidisciplinary project on breast cancer: The epidemiology, aetiology and prevention of breast cancer

1986 • 78 citations

Progression from hormone dependence to autonomy in mammary tumors as an in vivo manifestation of sequential clonal selection.

1975 • 74 citations

Estrogen receptor quantitation and staging as complementary prognostic indicators in breast cancer: A study of 583 patients

1981 • 74 citations

Intraneoplastic diversity

1982 • 73 citations

Epidermal growth factor receptor status of histological sub-types of breast cancer

1988 • 72 citations

Interactions of antiestrogens with human breast cancer in long-term tissue culture.

1976 • 68 citations

The epidemic of endometrial cancer: a commentary.

1980 • 65 citations

Ablation Therapy for Hormone-Dependent Tumors

1972 • 65 citations

Secretory carcinoma of the breast in adults. Light and electron microscopic study of three cases with review of the literature

1983 • 64 citations

Physiological and pharmacological effects of estrogens in breast cancer

1979 • 62 citations

The inter-relationships between ovarian-independent growth, tumorigenicity, invasiveness and antioestrogen resistance in the malignant progression of human breast cancer

1989 • 57 citations

Use of two MCF-7 cell variants to evaluate the growth regulatory potential of estrogen-induced products.

1986 • 51 citations

The prognostic role of progesterone receptors in human breast cancer.

1983 • 50 citations

Hormone-dependent mammary tumors in mice and rats as a model for human breast cancer (review).

1983 • 42 citations

The sex hormone profile of male patients with breast cancer

1983 • 41 citations

Estrogen receptor distribution in the peripheral, intermediate and central regions of breast cancers

1988 • 38 citations

Some comments on the necessity of receptor determination in human breast cancer.

1978 • 38 citations

Estrogen Receptor Levels and Survival of Breast Cancer Patients: A study on patients participating in randomized trials of adjuvant therapy

1987 • 35 citations

Immune-deficient animals to study “hormone-dependent” breast and endometrial cancer

1989 • 32 citations

Serum steroid levels in intact and endocrine ablated BALB/C nude mice and their intact littermates

1986 • 30 citations

Do antiestrogens and antiprogestins act as hormone antagonists or receptor-targeted drugs in breast cancer?

1987 • 29 citations

Estrogen induced growth of human breast cancer cells (MCF-7) in athymic nude mice is enhanced by secretions from a transplantable pituitary tumor

1981 • 28 citations

Unusual androgen sensitivity of the androgen-independent Dunning R-3327-G rat prostatic adenocarcinoma: androgen effect on tumor cell loss.

1982 • 27 citations

Survey of primary liver tumors and oral contraceptive use

1979 • 25 citations

Effect of cytotoxic drugs on estrogen receptor expression and response to tamoxifen in MCF-7 cells.

1986 • 24 citations

Steroid receptors and disease: cancer, autoimmune, bone and circulatory disorders

1989 • 22 citations

Role of estrogen and prolactin in the growth and receptor levels of N-nitrosomethylurea-induced rat mammary tumors.

1982 • 21 citations

Estrogen Receptor Status and the Disease-Free Interval in Breast Cancer

1980 • 20 citations

Reduction of estrogen receptor concentration in MCF-7 human breast carcinoma cells following exposure to chemotherapeutic drugs.

1983 • 20 citations

Quantitative estrogen receptor values and growth of carcinoma of the breast before surgical intervention

1982 • 20 citations

Immune-deficient animals in experimental medicine

1990 • 18 citations

Molecular endocrinology and steroid hormone action

1990 • 18 citations

Accelerated progression to autonomy of a pregnancy-dependent mouse mammary tumor (TPDMT-4) by hormones.

1983 • 14 citations

Prolactin and breast cancer

1988 • 12 citations

Pharmacological and suprapharmacological concentrations of both 17β-oestradiol and tamoxifen reduce the membrane fluidity of MCF-7 and MDA-MB-436 human breast cancer cells

1987 • 12 citations

Mechanisms of hormone and cytotoxic drug interactions in the development and treatment of breast cancer.

1990 • 8 citations

In vivo/in vitro Selection of Hormone-Independent Cells from the Hormone-Dependent MCF-7 Human Breast Cancer Cell Line

2015 • 3 citations

Growth regulation of cancer II

1991 • 3 citations

11 Clonal Heterogeneity in Relation to Response

2015 • 2 citations