Physiological and pharmacological effects of estrogens in breast cancer

A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2

1973 • 2,431 citations

ON THE TREATMENT OF INOPERABLE CASES OF CARCINOMA OF THE MAMMA: SUGGESTIONS FOR A NEW METHOD OF TREATMENT, WITH ILLUSTRATIVE CASES.1

1896 • 1,240 citations

Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor.

1978 • 797 citations

Etiology of Human Breast Cancer: A Review2

1973 • 781 citations

Mechanism of Action of the Female Sex Hormones

1972 • 763 citations

Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer.

1977 • 694 citations

A New Anti-oestrogenic Agent in Late Breast Cancer: An Early Clinical Appraisal of ICI46474

1971 • 692 citations

Estrogen Receptors in Human Breast Cancer

1976 • 621 citations

WOODPECKERS' TONGUES

1976 • 553 citations

A MONOHYDROXYLATED METABOLITE OF TAMOXIFEN WITH POTENT ANTIOESTROGENIC ACTIVITY

1977 • 502 citations

Prolactin and murine mammary tumorigenesis: a review.

1977 • 465 citations

A NEW DERIVATIVE OF TRIPHENYLETHYLENE: EFFECT ON IMPLANTATION AND MODE OF ACTION IN RATS

1967 • 456 citations

Current status of estrogen and progesterone receptors in breast cancer

1977 • 392 citations

STEROID AND PHYTO-OESTROGEN BINDING TO SHEEP UTERINE RECEPTORS IN VITRO

1972 • 390 citations

SOME EFFECTS OF ORAL CONTRACEPTIVES ON CARBOHYDRATE METABOLISM

1966 • 387 citations

Anti-oestrogen Therapy for Breast Cancer: A Trial of Tamoxifen at Two Dose Levels

1973 • 373 citations

Mechanisms Regulating the Concentration and the Conformation of Progesterone Receptor(s) in the Uterus

1973 • 361 citations

Estrogenic activity of DDT analogs and polychlorinated biphenyls

1970 • 357 citations

<italic>N</italic>-Nitrosomethylurea as Mammary Gland Carcinogen in Rats

1975 • 354 citations

Comparative binding affinity of estrogens and its relation to estrogenic potency

1969 • 335 citations

Estrogen-Induced Uterine Responses and Growth: Relationship to Receptor Estrogen Binding by Uterine Nuclei1¹

1975 • 321 citations

Assessment of response to therapy in advanced breast cancer

1977 • 316 citations

Contrasting Endocrine Activities of cis and trans Isomers in a Series of Substituted Triphenylethylenes

1966 • 315 citations

Progesterone receptors in normal and neoplastic tissues

1977 • 310 citations

Influence of Synthetic Oestrogens on Advanced Malignant Disease

1944 • 298 citations

Mechanism of Action of the Sex Steroid Hormones

1976 • 288 citations

Estrogen-binding substances of target tissues

1969 • 251 citations

Relation Between Estrogen Inhibitory Activity and Binding to Cytosol of Rabbit and Human Uterus

1970 • 246 citations

Nuclear Binding and Retention of the Receptor Estrogen Complex: Relation to the Agonistic and Antagonistic Properties of Estriol1¹

1977 • 245 citations

Oestrogen receptors and antagonism of steroid hormone action

1974 • 242 citations

Specific Estrogen Binding by the Cytoplasm of Human Breast Carcinoma

1970 • 234 citations

Nuclear retention of receptor–oestrogen complex and nuclear acceptor sites

1976 • 228 citations

Photoaffinity labels for estrogen binding proteins of rat uterus

1973 • 220 citations

HÆMOPHILIA CARRIERS

1974 • 214 citations

STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTI-OESTROGENS WITH REGARD TO INTERACTION WITH 17β-OESTRADIOL IN THE MOUSE UTERUS AND VAGINA

1971 • 211 citations

1,25-Dihydroxycholecalciferol and Parathormone: Effects on Isolated Osteoclast-Like and Osteoblast-Like Cells

1977 • 207 citations

Low incidence of estrogen receptor in breast carcinomas with rapid rates of cellular replication

1977 • 195 citations

Estrogen receptor · anti-estrogen complex: Atypical binding by uterine nuclei and effects on uterine growth

1973 • 195 citations

Hormonal Pathogenesis of Adenocarcinoma of the Breast

1936 • 195 citations

Tamoxifen is a potent ‘pure’ anti-oestrogen in chick oviduct

1977 • 184 citations

The Metabolism of Tamoxifen (I.C.I. 46,474) Part I : In Laboratory Animals

1973 • 181 citations

Antiestrogen Action in the Uterus: Biological Ineffectiveness of Nuclear Bound Estradiol after Antiestrogen¹²³

1975 • 181 citations

DISODIUM CROMOGLYCATE IN BRONCHIAL ASTHMA

1968 • 181 citations

Effects of dichlorodiphenyltrichloroethane (DDT) analogs and polychlorinated biphenyl (PCB) mixtures on 17β-[3H]estradiol binding to rat uterine receptor

1974 • 158 citations

Estrogen receptor content and hormone-responsive growth of mouse mammary tumors.

1974 • 150 citations

Cytochemical Study of Estrogen Receptor in Human Mammary Cancer

1978 • 141 citations

Relationship between oestrogen-receptor content and histological grade in human primary breast tumours

1978 • 137 citations

The Metabolism of Tamoxifen (I.C.I. 46,474) Part II: In Female Patients

1973 • 136 citations

TAMOXIFEN AS AN ANTI-TUMOUR AGENT: EFFECT ON OESTROGEN BINDING

1976 • 134 citations

Dynamics of oestrogen-receptor distribution between the cytosol and nuclear fractions of immature rat uterus after oestradiol administration

1975 • 134 citations

Studies on the mechanism of action of the nonsteroidal antioestrogen tamoxifen (I.C.I. 46,474) in the rat

1977 • 131 citations

Estrogen receptor. Unoccupied sites in nuclei of a breast tumor cell line.

1977 • 131 citations

An improved assay for nuclear estrogen receptor in experimental and human breast cancer.

1977 • 130 citations

Significance of quantitative assessment of estrogen receptors for endocrine therapy in advanced breast cancer

1977 • 129 citations

Effects of estrone, estradiol, and estriol on hormone-responsive human breast cancer in long-term tissue culture.

1977 • 129 citations

Temporal Relationships Between Hormone Receptor Binding and Biological Responses inthe Uterus: Studies with Short- and Long-Acting Derivatives of Estriol

1976 • 128 citations

Relation of Prolactin and Estrogen to Mammary Tumorigenesis in the Rat<xref ref-type="fn" rid="FN1">1</xref><xref ref-type="fn" rid="FN2">2</xref>

1972 • 126 citations

The specificity of the estrogen receptor of human uterus

1973 • 121 citations

Oestrogen receptors in breast cancer: a changing concept.

1975 • 121 citations

Urine œstrogen profiles OF Asian and North American women

1974 • 118 citations

Different Nuclear Binding Sites for Antiestrogen and Estrogen Receptor Complexes¹,²

1977 • 117 citations

Formation of estrogen nuclear receptor in uterus: Effect of androgens, estrone and nafoxidine

1972 • 111 citations

Preliminary trial of aminoglutethimide in breast cancer

1973 • 110 citations

Comparative study of estrogen action.

1973 • 107 citations

Endocrine control in neoplasia

1978 • 106 citations

Comparison of macromolecular binding of estradiol in hormone-dependent and hormone-independent rat mammary carcinoma.

1971 • 105 citations

Immunofluorescent detection of estrogen receptors in breast cancer.Comparison with dextran-coated charcoal and sucrose gradient assays

1978 • 105 citations

Anti-estrogen interaction with uterine estrogen receptors. Studies with a radiolabeled anti-estrogen (CI-628).

1978 • 103 citations

Estrogens and Antiestrogens

1972 • 103 citations

Generality of oestrogen stimulation of peroxidase activity in growth responsive tissues

1977 • 100 citations

Oestrogen-induced progesterone receptor in human uterus

1975 • 99 citations

Estrogen Profiles of Oriental and Caucasian Women in Hawaii

1974 • 98 citations

TAMOXIFEN AS AN ANTI-TUMOUR AGENT: OESTROGEN BINDING AS A PREDICTIVE TEST FOR TUMOUR RESPONSE

1976 • 96 citations

Characterization and assay of progesterone receptor in human mammary carcinoma.

1977 • 96 citations

The effect of synthetic anti-oestrogens on the growth and biochemistry of rat mammary tumours

1975 • 96 citations

Detection and dynamic localisation of estradiol-receptor complexes in intact target cells by immunofluorescence technique

1976 • 94 citations

Medical Adrenalectomy with Aminoglutethimide

1978 • 92 citations

AMINOGLUTETHIMIDE IN TREATMENT OF METASTATIC BREAST CARCINOMA

1978 • 91 citations

DOSE-RELATED EFFECTS OF NON-STEROIDAL ANTIOESTROGENS AND OESTROGENS ON THE MEASUREMENT OF CYTOPLASMIC OESTROGEN RECEPTORS IN THE RAT AND MOUSE UTERUS

1978 • 88 citations

Estrogen Receptor Translocation and Replenishment by the Antiestrogen Tamoxifen

1977 • 88 citations

Human Breast Cancer: Biologically Active Estrogen Receptor in the Absence of Estrogen?

1977 • 86 citations

A Comparative Study of Antiestrogen Action: Temporal Patterns of Antagonism of Estrogen Stimulated Uterine Growth and Effects on Estrogen Receptor Levels¹²³

1977 • 86 citations

Estradiol receptors in mouse mammary tumors: Absence of the transfer of bound estradiol from the cytoplasm to the nucleus

1972 • 85 citations

Photoreactivity of some light-sensitive estrogen derivatives. Use of an exchange assay to determine their photointeraction with the rat uterine estrogen binding protein

1974 • 85 citations

Breast Cancer: trends in Research and Treatment

1977 • 82 citations

Regulation of Estrogen Receptors in Ovarian-Dependent Rat Mammary Tumors. I. Effects of Castration and Prolactin

1976 • 78 citations

Nuclear Receptor Estradiol Complex: A Requirement for Uterotrophic Responses¹

1974 • 78 citations

Estrogen receptor and endocrine responsiveness in Japanese versus American breast cancer patients.

1977 • 78 citations

Mechanism of Action of the Sex Steroid Hormones

1976 • 76 citations

Sex hormone receptors in mammary tumours of GR mice

1976 • 76 citations

The properties of a nuclear acidic protein fraction that binds [6,7−3H]oestradiol-17β

1969 • 75 citations

Progression from hormone dependence to autonomy in mammary tumors as an in vivo manifestation of sequential clonal selection.

1975 • 74 citations

Estrogen receptor characterization in a transplantable mouse mammary tumor.

1977 • 74 citations

TAMOXIFEN AS AN ANTI-TUMOUR AGENT: ROLE OF OESTRADIOL AND PROLACTIN

1976 • 70 citations

In vivo effect of anti-estrogens on the localisation and replenishment of estrogen receptor

1975 • 69 citations

Binding of [3h]tamoxifen in rat uterine cytosols: A comparison of swinging bucket and vertical tube rotor sucrose density gradient analysis

1977 • 66 citations

The effect of antiestrogens on the nuclear binding of the estrogen receptor

1974 • 65 citations

Effect of the antiestrogen C1628 on the growth of rat mammary tumors.

1974 • 65 citations

Antioestrogens in Treatment of Breast Cancer: Value of Nafoxidine in 52 Advanced Cases

1974 • 65 citations

High-affinity binding of the antiestrogen [3H]tamoxifen to the 8S estradiol receptor

1978 • 65 citations

Prolactin and progesterone effect on specific estradiol binding in uterine and mammary tissues invitro

1973 • 64 citations

Estrogen and prolactin receptor concentrations in rat mammary tumors and response to endocrine ablation.

1976 • 64 citations

Anti-oestrogens and breast cancer

1971 • 61 citations

Antiestrogen action: Differential nuclear retention and extractability of the estrogen receptor

1976 • 59 citations

The role of hormones in the etiology of human breast cancer

1977 • 58 citations

Inhibition of DMBA-Induced Mammary Carcinogenesis in the Rat by 2-Br-α-Ergocryptine (CB 154), An Inhibitor of Prolactin Secretion, and by Nafoxidine (U-11, 100 A), an Estrogen Antagonist

1971 • 54 citations

Uncharged nuclear receptors for estrogen in breast cancers.

1978 • 53 citations

Comparative trial of nafoxidine and ethinyloestradiol in advanced breast cancer: an E.O.R.T.C. study.

1975 • 53 citations

Antagonism of development and growth of 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors by the antiestrogen U 23,469 and effects on estrogen and progesterone receptors.

1977 • 52 citations

Identification, subcellular localization, and estrogen regulation of peroxidase in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors.

1975 • 52 citations

Clinical trial of clomiphene in advanced breast cancer

1974 • 52 citations

A Dissociation Between Ovarian Dependent Growth and Estrogen Sensitivity in Mammary Carcinoma

1971 • 52 citations

NUCLEAR $OElig;STROGEN RECEPTORS AND TREATMENT OF BREAST CANCER

1977 • 51 citations

Clinical trial of nafoxidine, an oestrogen antagonist in advanced breast cancer

1972 • 50 citations

Oestrogen and androgen receptors in breast cancer and response to endocrine therapy.

1975 • 50 citations

Mechanism of Action of the Sex Steroid Hormones

1976 • 49 citations

Clinical Lectures ON THE BORDERLAND OF EPILEPSY: VERTIGO: Delivered at the National Hospital for the Paralysed and Epileptic

1906 • 49 citations

INHIBITION OF OESTROGEN-STIMULATED PROLACTIN RELEASE BY ANTI-OESTROGENS

1975 • 48 citations

Antiestrogen Modulation of the Salt-Resistant Nuclear Estrogen Receptor*

1978 • 48 citations

Estrogenicity of o,p'-DDT in rats

1971 • 48 citations

The influence of synthetic anti-estrogens on the binding of tritiated estradiol-17β by cytosols of human uterus and human breast carcinoma

1973 • 47 citations

Two methods for measurement of oestradiol-17β and progesterone receptors in human breast cancer and correlation with response to treatment

1977 • 46 citations

Effects of oestradiol-17β and tamoxifen on total and accessible cytoplasmic oestradiol-17β receptors in DMBA-induced rat mammary tumours

1976 • 45 citations

Cancer therapy : prognostic factors and criteria of response

1975 • 43 citations

The use of antiestrogens tamoxifen and nafoxidine in the treatment of human breast cancer in correlation with estrogen receptor values.A phase II study

1978 • 39 citations

The Treatment of Breast Cancer

1974 • 39 citations

Observations on the hormone sensitivity of 7,12-dimethylbenz(alpha)anthracene-induced mammary tumors in the Sprague-Dawley rat.

1970 • 36 citations

Breast cancer: potentially predisposing and protecting factors. Role of pregnancy, lactation, and endocrine status.

1978 • 34 citations

Estradiol dependent decrease of binding inhibition by anti-estrogens (a possible test of receptor activation)

1977 • 34 citations

X-ray conformation of some estrogens and their binding to uterine receptors

1975 • 33 citations

Effect of anti-oestrogens on initiation of mammary cancer in the female rat

1971 • 33 citations

Effects of oestradiol-17β and tamoxifen on nuclear oestradiol-17β receptors in DMBA-induced rat mammary tumours

1977 • 30 citations

Parallelism between oestrogen binding capacity and hormone responsiveness of mammary tumours in GR/A mice

1972 • 29 citations

Controlled clinical trial of L-dopa and nafoxidine in advanced breast cancer: an E.O.R.T.C. study.

1975 • 29 citations

Specific estrogen binding in rat mammary tumors induced by 7,12-dimethylbenz(a)anthracene.

1975 • 28 citations

Estrogen receptor in normal and neoplastic mouse mammary tissues.

1974 • 27 citations

Estradiol-dependent collagenolytic enzyme activity in long-term organ culture of human breast cancer.

1975 • 26 citations

Receptor transformation, the key to estrogen action

1975 • 26 citations

On the mechanism of hormone action in 7, 12 dimethylbenz(A) anthracene-induced mammary tumor. I. Prolactin and progesterone effects on estrogen receptor in vitro

1975 • 25 citations

In vitro and in vivo interactions of [3H]dimethylstilbestrol with the estrogen receptor

1977 • 24 citations

Estrogen receptors in the spectrum of breast cancer

1976 • 23 citations

Growth-stimulating effect of Nafoxidine on rat mammary tumor after ovariectomy

1973 • 22 citations

Peroxidase in estrogen-sensitive tissues

1976 • 22 citations

The prognostic significance of estrogen receptors in human breast cancer

1978 • 22 citations

Influence of hormonal alteration of host on estrogen-binding capacity in 7,12-dimethylbenz(a)anthracene-induced mammary tumors.

1976 • 22 citations

Affinity of estradiol mustard for estrogen receptors and its enzymatic degradation in uterine and breast cancer cytosols

1976 • 22 citations

Oestrogen receptors in male breast cancer.

1976 • 21 citations

Oestrogen receptor activity and endocrine status in DMBA-induced rat mammary tumours

1977 • 20 citations

Potent Inhibitory Effect of a New Antiestrogen (RU 16117) on the Growth of 7,12-Dimethylbenz[ a ]anthracene-lnduced Rat Mammary Tumors

1977 • 20 citations

Determination of estrogen receptors in canine mammary tumors.

1977 • 20 citations

The steroid specificiy of the estrogen-receptor of human breast carcinoma

1974 • 19 citations

Estrogen receptors interaction with Estracyt and degradation products, a biochemical study on a potential agent in the treatment of breast cancer

1976 • 19 citations

Hexoestrol Analogues as Probes of Oestrogen Receptors I. Importance of Hydrogen‐Bonding Groups for Receptor Binding

1972 • 16 citations

Specific estrogen receptor of the DMBA-induced mammary carcinoma of the rat and its estrogen-requiring molecular transformation

1973 • 16 citations

Estrogen-binding in vitro by DMBA-induced rat mammary tumors: its relationship to hormone responsiveness

1974 • 15 citations

ANTI-OESTROGEN ACTION: UTERINE NUCLEAR RETENTION OF THE CI-628 ANTI-OESTROGEN RECEPTOR COMPLEX IN VITRO

1977 • 14 citations

Interaction of activated estradiol-receptor complex and chromatin in isolated uterine nuclei

1973 • 13 citations

Co-purification of an oestrogen-induced protein from rat uterus and a factor able to stimulate DNA synthesis in cultured cells

1977 • 12 citations

Receptors and breast cancer: Do we know it all?

1978 • 11 citations

<italic>Brief Communication:</italic> Estrogen-Dependent In Vitro Stimulation of RNA Synthesis in Hormone-Dependent Mammary Tumors of the Rat<xref ref-type="fn" rid="fn2">2</xref>

1975 • 11 citations

Antibody to estrogen-induced protein (IP) and quantification of the protein in rat uterus by a radioimmunoassay

1977 • 9 citations

Clinical trial of nafoxidine in advanced breast cancer

1978 • 9 citations

Structure cristalline et moléculaire du cycladiène (dièneoestrol)

1972 • 8 citations

Fluctuations in Levels of Cytosol and Nuclear Estrogen Receptors in Rat Mammary Tumors during the Estrous Cycle*

1978 • 8 citations

Regulation of Macromolecular Synthesis by Oestrogen: A Developmental Approach

1975 • 8 citations

OESTROGEN-INDUCED PROTEIN IN RAT MAMMARY TUMOUR AND UTERUS

1977 • 8 citations

Antitumour effect of cyclofenil (F6066) on DMBA-induced rat mammary tumors

1978 • 7 citations

The oestrogenic and anti-oestrogenic properties of ring methyl-substituted stilboestrols

1971 • 7 citations

Estrogen receptor levels in hormonally progressive mammary tumors

1977 • 6 citations

Estrogen Receptors in DMBA-Induced Rat Mammary Tumors before and after Ovariectomy

1977 • 5 citations

EFFECT OF PROLACTIN ON SPECIFIC OESTRADIOL RECEPTORS IN THE RAT UTERUS

1977 • 5 citations

EXTRAOVARIAN EFFECT OF PROLACTIN ON THE TRAUMATIZED UTERUS IN THE RAT

1975 • 5 citations

GROWTH INHIBITION OF ESTROGEN-DEPENDENT RAT MAMMARY CANCER BY EMD 16-795, A NEW SYNTHETIC ANTI-ESTROGEN

1971 • 4 citations

Plasma oestradiol-17B and oestrogen receptors in mammary tumours among Africans.

1977 • 2 citations