Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Modified Spin-Echo Method for Measuring Nuclear Relaxation Times

1958 • 5,632 citations

Enzyme structure and mechanism

1977 • 2,935 citations

Plasminogen: Purification from Human Plasma by Affinity Chromatography

1970 • 2,160 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

A biochemical abnormality in hereditary angioneurotic edema

1963 • 955 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

Biophysical Chemistry: Part II: Techniques for the Study of Biological Structure and Function

1980 • 863 citations

[2] Titration of trypsin, plasmin, and thrombin with p-nitrophenyl p′-guanidinobenzoate HCl

1970 • 497 citations

Human C.hivin.1 inhibitor: primary structure, cDNA cloning, and chromosomal localization

1986 • 328 citations

SUICIDE SUBSTRATES, MECHANISM-BASED ENZYME INACTIVATORS: RECENT DEVELOPMENTS

1984 • 296 citations

Studies on human plasma C1 inactivator-enzyme interactions. I. Mechanisms of interaction with C1s, plasmin, and trypsin.

1975 • 219 citations

Contribution of Plasma Protease Inhibitors to the Inactivation of Kallikrein in Plasma

1982 • 218 citations

The regulation of human factor XIIa by plasma proteinase inhibitors.

1985 • 205 citations

Pulse methods for the simplification of protein NMR spectra

1975 • 191 citations

Inactivation of factor XII active fragment in normal plasma. Predominant role of C-1-inhibitor.

1984 • 180 citations

[63] Inactivation of trypsin-like enzymes with peptides of arginine chloromethyl ketone

1981 • 170 citations

Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins.

1990 • 168 citations

Inactivation of kallikrein in human plasma.

1983 • 161 citations

The effect of temperature on the fluorescence of some aromatic amino acids and proteins

1962 • 158 citations

Kinetics of suicide substrates. Practical procedures for determining parameters

1985 • 155 citations

Interaction of ¹²⁵I‐labelled complement subcomponents Cr and Cs with protease inhibitors in plasma

1979 • 147 citations

Proteolytic inactivation of plasma C1- inhibitor in sepsis.

1989 • 141 citations

Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor

1988 • 119 citations

Protection of human plasma kallikrein from inactivation by c.hivin.1 inhibitor and other protease inhibitors. The role of high molecular weight kininogen

1981 • 112 citations

Primary structure of the reactive site of human C1-inhibitor.

1985 • 107 citations

Heparin and ionic strength-dependent conversion of antithrombin III from an inhibitor to a substrate of alpha-thrombin.

1985 • 101 citations

Isolation and functional properties of the heavy and light chains of human plasma kallikrein.

1982 • 98 citations

Human plasma kallikrein. A rapid purification method with high yield

1981 • 96 citations

Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes.

1985 • 93 citations

Release of a Two‐Chain Form of Antithrombin from the Antithrombin‐Thrombin Complex

1979 • 81 citations

Production in vitro and properties of a modified form of bovine antithrombin, cleaved at the active site by thrombin.

1982 • 78 citations

Dysfunctional C1̅-inhibitor(At), isolated from a type II hereditary-angio-oedema plasma, contains a P1 ‘reactive centre’ (Arg444→His) mutation

1988 • 64 citations

Interaction of human plasma kallikrein and its light chain with C.hivin.1 inhibitor

1983 • 48 citations

Reactivity of alpha 1-antitrypsin mutants against proteolytic enzymes of the kallikrein-kinin, complement, and fibrinolytic systems.

1990 • 42 citations

Properties of antithrombin-thrombin complex formed in the presence and in the absence of heparin

1983 • 35 citations

A common neoepitope is created when the reactive center of C1-inhibitor is cleaved by plasma kallikrein, activated factor XII fragment, C1 esterase, or neutrophil elastase.

1988 • 35 citations

Antithrombin III and its interaction with heparin. Comparison of the human, bovine and porcine proteins by proton NMR spectroscopy

1987 • 33 citations

Human plasma kallikrein and C1 inhibitor form a complex possessing an epitope that is not detectable on the parent molecules: demonstration using a monoclonal antibody.

1985 • 30 citations

Human plasma prekallikrein. Immunoaffinity purification and activation to alpha- and beta-kallikrein.

1986 • 25 citations

Structural and circular-dichroism studies on the interaction between human C̅1-esterase inhibitor and C̅1s

1983 • 24 citations

Serine protease inhibitors (serpins)

1991 • 18 citations

C-1 inactivator and cold-promoted activation of factor VII.

1978 • 14 citations

“In vivo” and “in vitro” Inhibition of Human Pancreatic Chymotrypsin A by Serum Inhibitors

1987 • 6 citations