Upregulation of Intracellular Glutathione by Fibroblast-Derived Factor(s): Enhanced Survival of Activated T Cells in the Presence of Low Bcl-2

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

GLUTATHIONE

1983 • 5,487 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Reactive oxygen species in living systems: Source, biochemistry, and role in human disease

1991 • 1,827 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

INFECTIOUS MONONUCLEOSIS

1948 • 1,185 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Oxidants and antioxidants: State of the art

1991 • 623 citations

Antigen-independent activation of naive and memory resting T cells by a cytokine combination.

1994 • 541 citations

Reactive oxygen species and antioxidant vitamins: Mechanisms of action

1994 • 531 citations

Virus-specific CD8+ T-cell memory determined by clonal burst size

1994 • 525 citations

Inhibition of T cell apoptosis in the rheumatoid synovium.

1997 • 474 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens.

1990 • 383 citations

T cell memory is short-lived in the absence of antigen.

1991 • 367 citations

Interleukin‐2 receptor common γ‐chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti‐apoptotic (bcl‐2, bcl‐x_L) but not pro‐apoptotic (bax, bcl‐x_S) gene expression

1996 • 367 citations

The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory.

1993 • 350 citations

T and B memory cells

1994 • 285 citations

BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells.

1996 • 251 citations

Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis

1994 • 245 citations

Lymphocyte lifespans: homeostasis, selection and competition

1993 • 226 citations

Long-term T-cell-mediated immunity to Epstein-Barr virus.

1981 • 213 citations

Apoptosis in Viral Infections

1995 • 210 citations

Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen.

1992 • 204 citations

Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine

1990 • 184 citations

Fas‐mediated apoptosis is modulated by intracellular glutathione in human T cells

1996 • 169 citations

Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase.

1989 • 164 citations

The role of glutathione in lymphocyte activation. I. Comparison of inhibitory effects of buthionine sulfoximine and 2-cyclohexene-1-one by nuclear size transformation.

1985 • 153 citations

Induction of apoptosis at different oxygen tensions: evidence that oxygen radicals do not mediate apoptotic signaling.

1995 • 142 citations

A possible role for bcl-2 in regulating T-cell memory - a ‘balancing act’ between cell death and survival

1993 • 131 citations

Glutathione Regulates Interleukin-2 Activity on Cytotoxic T-cells

1989 • 127 citations

Lipid hydroperoxide‐induced apoptosis: lack of inhibition by Bcl‐2 over‐expression

1995 • 108 citations

Gluthatione Augments the Activation of Cytotoxic T Lymphocytes in vivo

1986 • 94 citations

Presence of CD3+CD8+Bcl-2(low) lymphocytes undergoing apoptosis and activated macrophages in lymph nodes of HIV-1+ patients.

1995 • 87 citations

Radioprotection of human lymphoid cells by exogenously supplied glutathione is mediated by gamma-glutamyl transpeptidase.

1983 • 86 citations

The role of mitochondrial glutathione and cellular protein sulfhydryls in formaldehyde toxicity in glutathione-depleted rat hepatocytes

1986 • 84 citations

The export of glutathione from human diploid cells in culture.

1979 • 81 citations

Enhancement of intracellular glutathione promotes lymphocyte activation by mitogen

1986 • 76 citations

Fibroblasts mediate T cell survival: a proposed mechanism for retention of primed T cells.

1990 • 76 citations

Increased numbers of cells with suppressor T cell phenotype in the peripheral blood of patients with infectious mononucleosis.

1981 • 69 citations

Anti-TAPA-1 antibodies induce protein tyrosine phosphorylation that is prevented by increasing intracellular thiol levels.

1993 • 64 citations

Fibroblasts prevent apoptosis of IL‐2‐deprived T cells without inducing proliferation: a selective effect on Bcl‐x_L expression

1996 • 64 citations

Expression of CD45R0 (UCHL1) by CD4+ and CD8+ T cells as a sign of in vivo activation in infectious mononucleosis

1991 • 61 citations

Interleukin-2 mRNA expression, lymphokine production and DNA synthesis in glutathione-depleted T cells

1990 • 59 citations

N-Acetylcysteine: Potential for AIDS Therapy

1993 • 58 citations

Modulation of T-cell function

1981 • 56 citations

The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).

1980 • 54 citations

Specificity and editing by apoptosis of virus-induced cytotoxic T lymphocytes

1994 • 36 citations

Infectious Mononucleosis

2011 • 13 citations

Enhancement of Glutathione Content in Glutathione Synthetase-Deficient Fibroblasts from a Patient with 5-Oxoprolinuria via Metabolic Cooperation with Normal Fibroblasts

1994 • 10 citations

Cysteine Produced from Lymph Node Stromal Cells Suppresses Apoptosis of Mouse Malignant T-Lymphoma Cells

1995 • 10 citations

Deleted Work

1955 • 0 citations