N-Methyl(R)Salsolinol: A Neurotoxin Candidate to Induce Parkinson’s Disease Causes Apoptosis in Dopamine Cells

Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells

1984 • 1,672 citations

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1997 • 1,016 citations

Histochemical detection of apoptosis in Parkinson's disease

1996 • 448 citations

Mitochondrial respiratory chain inhibitors induce apoptosis

1994 • 403 citations

Complex I Inhibitors Induce Dose‐Dependent Apoptosis in PC12 Cells: Relevance to Parkinson's Disease

1994 • 365 citations

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

1991 • 215 citations

Modulation of gene expression rather than monoamine oxidase inhibition

1996 • 166 citations

Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies

1996 • 127 citations

Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence

1981 • 120 citations

Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines

1990 • 115 citations

A dopaminergic neurotoxin, (R)‐N‐methylsalsolinol, increases in parkinsonian cerebrospinal fluid

1996 • 103 citations

N-methyl(r)salsolinol produces hydroxyl radicals: Involvement to neurotoxicity

1995 • 97 citations

An Endogenous Dopaminergic Neurotoxin, N‐Methyl‐(R)‐Salsolinol, Induces DNA Damage in Human Dopaminergic Neuroblastoma SH‐SY5Y Cells

1997 • 97 citations

A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigro-striatal system of the human brain

1997 • 93 citations

Alkaloids in mammalian tissues. 2. Synthesis of (+)- and (-)-1-substituted-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines

1972 • 83 citations

Dopamine‐Derived 1‐Methyl‐6,7‐Dihydroxyisoquinolines as Hydroxyl Radical Promoters and Scavengers in the Rat Brain: In Vivo and In Vitro Studies

1995 • 60 citations

N-Methyl-(R)salsolinol as a dopaminergic neurotoxin: From an animal model to an early marker of Parkinson’s disease

1997 • 58 citations

A neurotoxin N-methyl(R)salsolinol induces apoptotic cell death in differentiated human dopaminergic neuroblastoma SH-SY5Y cells

1997 • 46 citations

1-Methyl-4-phenylpyridinum kills differentiated PC12 cells with a concomitant change in protein phosphorylation

1994 • 30 citations