N-Methyl-(R)salsolinol as a dopaminergic neurotoxin: From an animal model to an early marker of Parkinson’s disease

A simple technique for quantitation of low levels of DNA damage in individual cells

1988 • 10,537 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells

1984 • 1,672 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease

1989 • 735 citations

Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds

1993 • 541 citations

Histochemical detection of apoptosis in Parkinson's disease

1996 • 448 citations

Complex I Inhibitors Induce Dose‐Dependent Apoptosis in PC12 Cells: Relevance to Parkinson's Disease

1994 • 365 citations

New insights into the cause of Parkinson's disease

1992 • 272 citations

Biochemical Events in the Development of Parkinsonism Induced by 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine

1987 • 246 citations

An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions

1988 • 200 citations

Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies

1996 • 127 citations

Evidence for neuromelanin involvement in MPTP-induced neurotoxicity

1987 • 120 citations

A N-methyltransferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion

1989 • 110 citations

A dopaminergic neurotoxin, (R)‐N‐methylsalsolinol, increases in parkinsonian cerebrospinal fluid

1996 • 103 citations

N‐Methylation of Dopamine‐Derived 6,7‐Dihydroxy‐1,2,3,4‐Tetrahydroisoquinoline, (R)‐Salsolinol, in Rat Brains: In Vivo Microdialysis Study

1992 • 102 citations

Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system

1994 • 99 citations

N-methyl(r)salsolinol produces hydroxyl radicals: Involvement to neurotoxicity

1995 • 97 citations

Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity by 1-methyl-4-phenylpyridinium ion

1987 • 97 citations

Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains

1991 • 96 citations

Alcohol drinking in the rat induced by acute intracerebral infusion of two tetrahydroisoquinolines and a β-carboline

1977 • 95 citations

Indole-N-methylated β-carbolinium ions as potential brain-bioactivated neurotoxins

1992 • 91 citations

Rat brain salsolinol and blood-brain barrier

1981 • 81 citations

Biosynthesis of salsolinol, a tetrahydroisoquinoline alkaloid, in healthy subjects

1990 • 75 citations

Neurotoxins, parkinsonism and Parkinson's disease

1987 • 73 citations

Ratio of the R and S enantiomers of salsolinol in food and human urine

1989 • 70 citations

Alzheimer’s and Parkinson’s Disease

1986 • 67 citations

Dopamine‐Derived 1‐Methyl‐6,7‐Dihydroxyisoquinolines as Hydroxyl Radical Promoters and Scavengers in the Rat Brain: In Vivo and In Vitro Studies

1995 • 60 citations

Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)

1995 • 58 citations

Salsolinol and catecholamines in human brain and their relation to alcoholism.

1982 • 56 citations

Novel S‐Adenosylmethionine‐Dependent Indole‐N‐Methylation of β‐Carbolines in Brain Particulate Fractions

1992 • 56 citations

Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatographic column

1995 • 54 citations

Simple assay procedure for tyrosine hydroxylase activity by high-performance liquid chromatography employing coulometric detection with minimal sample preparation

1988 • 54 citations

Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain

1992 • 52 citations

Enzymatic oxidation of the dopaminergic neurotoxin, 1 (R), 2(N)-Dimethyl-6,7-Dihydroxy-l,2,3,4-Tetrahydroisoquinoline, into 1,2(N)-Dimethyl-6,7-Dihydroxyisoquinolinium ion

1995 • 48 citations

Determination of total dopamine, R- and S-salsolinol in human plasma by cyclodextrin bonded-phase liquid chromatography with electrochemical detection

1994 • 47 citations

Enantiomeric composition of urinary salsolinol in Parkinsonian patients after Madopar

1989 • 43 citations

Novel toxins and Parkinson’s disease: N-methylation and oxidation as metabolic bioactivation of neurotoxin

1994 • 38 citations

Hyperactivity induced by tetrahydroisoquinoline derivatives injected into the nucleus accumbens

1976 • 31 citations

Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats

1993 • 31 citations

Binding of 1,2(N)-dimethyl-6,7-dihydroxy-isoquinolinium ion to melanin: Effects of ferrous and ferric ion on the binding

1994 • 27 citations

Adrenergic nerve degeneration induced by condensation products of adrenaline and acetaldehyde

1977 • 22 citations

Chapter 23 Dopamine-derived 6,7-dihydroxy-1,2,3, 4-tetrahydroisoquinolines; oxidation and neurotoxicity

1995 • 21 citations

1, 2, 3, 4‐Tetrahydro‐2‐Methyl‐4, 6, 7‐Isoquinolinetriol Depletes Catecholamines in Rat Brain

1993 • 17 citations

Inhibition of tyrosine hydroxylase by a dopamine neurotoxin, 1-methyl-4-phenylpyridiniumion: Depletion of allostery to the biopterin cofactor

1994 • 16 citations

Metabolic Bioactivation of Endogenous Isoquinolines as Dopaminergic Neurotoxins to Elicit Parkinson’s Disease

1995 • 13 citations

Multi-electrode detection systems for determination of neurotransmitters

1993 • 11 citations

Memory Impairment and Neural Dysfunction after Continuous Infusion of Anti-Nerve Growth Factor Antibody into the Septum in Adult Rats.

1994 • 11 citations

Deleted Work

1955 • 0 citations