Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities

Pancreatic Cancer

2000 • 7,332 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

2005 • 3,292 citations

Modulation of oxidative stress as an anticancer strategy

2013 • 3,034 citations

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

2008 • 2,551 citations

Pancreatic cancer

2011 • 2,252 citations

mTOR signaling at a glance

2009 • 2,005 citations

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

2012 • 1,769 citations

The history and future of targeting cyclin-dependent kinases in cancer therapy

2015 • 1,510 citations

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

2014 • 1,366 citations

Targeting cancer metabolism: a therapeutic window opens

2011 • 1,344 citations

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts

2004 • 1,165 citations

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

2014 • 1,083 citations

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

2015 • 987 citations

Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

2006 • 699 citations

Metabolic targets for cancer therapy

2013 • 667 citations

Pancreatic Cancer

2008 • 632 citations

KRAS: feeding pancreatic cancer proliferation

2014 • 628 citations

Mcl‐1; the molecular regulation of protein function

2010 • 502 citations

A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human Cancer

2003 • 421 citations

CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors

2014 • 405 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

2010 • 375 citations

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

2010 • 358 citations

Dual Mechanisms for the Inhibition of E2F Binding to RB by Cyclin-Dependent Kinase-Mediated RB Phosphorylation

1997 • 293 citations

Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

2012 • 279 citations

Therapeutic Advances in Pancreatic Cancer

2013 • 275 citations

The Drosophila Cyclin D-Cdk4 complex promotes cellular growth

2000 • 266 citations

E2F transcription factor-1 regulates oxidative metabolism

2011 • 251 citations

The meaning of p16^ink4aexpression in tumors

2011 • 249 citations

The Molecular Balancing Act of p16INK4a in Cancer and Aging

2013 • 248 citations

Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy

2012 • 233 citations

Molecular Pathways: CDK4 Inhibitors for Cancer Therapy

2014 • 232 citations

mTOR Signaling

2011 • 219 citations

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

2014 • 201 citations

Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function

2006 • 196 citations

Control of glutamine metabolism by the tumor suppressor Rb

2013 • 190 citations

MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies

2014 • 181 citations

Driving the Cell Cycle Through Metabolism

2011 • 131 citations

The retinoblastoma protein induces apoptosis directly at the mitochondria

2013 • 120 citations

Cdk4/6 Inhibition Induces Epithelial–Mesenchymal Transition and Enhances Invasiveness in Pancreatic Cancer Cells

2012 • 119 citations

The complex landscape of pancreatic cancer metabolism

2014 • 113 citations

CDK4/6 and IGF1 Receptor Inhibitors Synergize to Suppress the Growth of p16INK4A-Deficient Pancreatic Cancers

2014 • 108 citations

Loss of RBF1 changes glutamine catabolism

2013 • 89 citations

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

2015 • 82 citations

Cell cycle regulation of mitochondrial function

2014 • 81 citations

Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells

2015 • 71 citations

Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer

2015 • 54 citations

Emerging Links between E2F Control and Mitochondrial Function

2015 • 51 citations

Loss of Mcl-1 Protein and Inhibition of Electron Transport Chain Together Induce Anoxic Cell Death

2006 • 40 citations

Molecular Pathways: Regulation of Metabolism by RB

2012 • 33 citations

Loss of dE2F Compromises Mitochondrial Function

2013 • 30 citations