Is an Adaptation of NMDA Receptors an Obligatory Step in Antidepressant Action?

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes

1988 • 1,415 citations

Molecular diversity of the NMDA receptor channel

1992 • 1,354 citations

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1994 • 1,342 citations

Is the forced swimming test a suitable model for revealing antidepressant activity?

1988 • 1,053 citations

Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

1992 • 805 citations

Functional antagonists at the NMDA receptor complex exhibit antidepressant actions

1990 • 754 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Development of β-adrenergic receptor subsensitivity by antidepressants

1977 • 727 citations

Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain

1975 • 599 citations

[³H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes

1988 • 453 citations

The glycine site of the NMDA receptor — five years on

1993 • 440 citations

The Revised Monoamine Theory of Depression: A Modulatory Role for Monoamines, Based on New Findings From Monoamine Depletion Experiments in Humans

1996 • 382 citations

Mutational analysis of the glycine-binding site of the NMDA receptor: Structural similarity with bacterial amino acid-binding proteins

1994 • 381 citations

Gene expression in rat brain

1983 • 344 citations

Convulsive therapy : theory and practice

1979 • 319 citations

Regulated Subcellular Distribution of the NR1 Subunit of the NMDA Receptor

1995 • 290 citations

Convulsive therapy: Theory and practice

1980 • 281 citations

Alterations in the N-methyl-d-asparatate (NMDA) receptor complex in the frontal cortex of suicide victims

1995 • 263 citations

Phosphorylation of amino acid neurotransmitter receptors in synaptic plasticity

1993 • 260 citations

Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.

1994 • 241 citations

Glycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices

1989 • 234 citations

On the Slowness of Action of Tricyclic Antidepressant Drugs

1972 • 226 citations

[3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain

1991 • 212 citations

Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.

1993 • 192 citations

Preferential co-assembly of recombinant NMDA receptors composed of three different subunits

1993 • 190 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.

1988 • 189 citations

Glycine is a coagonist at the NMDA receptor/channel complex

1990 • 172 citations

Theoretical implications of drug-induced adaptive regulation for a biogenic amine hypothesis of affective disorder.

1974 • 164 citations

Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor

1989 • 154 citations

Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715)

1995 • 137 citations

Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site.

1995 • 137 citations

Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories

1991 • 124 citations

Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivo

1989 • 122 citations

Hypotheses concerning the mechanism of action of antidepressant drugs

1984 • 105 citations

Modulation of NMDA receptor-mediated responses by glycine and d-serine in the rat thalamus in vivo

1989 • 105 citations

1-Aminocyclopropanecarboxylates exhibit antidepressant and anxiolytic actions in animal models

1991 • 105 citations

The NMDA Receptor Channel: Molecular Design of a Coincidence Detector

1995 • 101 citations

In Vivo Modulation of the N‐Methyl‐D‐Aspartate Receptor Complex by D‐Serine: Potentiation of Ongoing Neuronal Activity as Evidenced by Increased Cerebellar Cyclic GMP

1989 • 100 citations

Clinical Pharmacology of Psychotherapeutic Drugs.

1979 • 94 citations

Pharmacological Models of Depression

1991 • 86 citations

Down-regulation of cortical β-adrenoceptors by chronic treatment with functional NMDA antagonists

1992 • 74 citations

Adaptation of cortical but not hippocampal NMDA receptors after chronic citalopram treatment

1996 • 70 citations

[3H]5,7-Dichlorokynurenic acid, a novel radioligand labels NMDA receptor-associated glycine binding sites

1991 • 66 citations

Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.

1993 • 62 citations

Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant

1995 • 58 citations

Calcium and magnesium concentrations in affective disorder: difference between plasma and serum in relation to symptoms

1989 • 57 citations

Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery

1996 • 55 citations

Calcium and electroconvulsive therapy of severe depressive illness.

1977 • 51 citations

Identifying changes in gene expression in the nervous system: mRNA differential display

1996 • 50 citations

Glycine, glycinamide and d-serine act as positive modulators of signal transduction at the N-Methyl-D-Aspartate (NMDA) receptor in vivo: Differential effects on mouse cerebellar cyclic guanosine monophosphate levels

1990 • 39 citations

Current Antidepressants

1986 • 37 citations

The effect of MK-801 and imipramine on beta-adrenergic and 5-HT2 receptors in the chronic mild stress model of depression in rats.

1994 • 35 citations

Independent regulation of β₁‐ and β₂‐adrenoceptors

1987 • 35 citations

Lack of effect of antipsychotic and antidepressant drugs on glutamate receptor mRNA levels in rat brains

1994 • 27 citations

A rapid method for evaluating the behavioral effects of phencyclidine-like dissociative anesthetics in mice

1991 • 26 citations

The development of our understanding of the mechanism of action of antidepressant drugs.

1991 • 25 citations

Biomedical aspects of depression and its treatment

1983 • 24 citations

Sustained exposure to 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, alters N-methyl-D-aspartate receptor function and subunit composition.

1995 • 21 citations

Delayed biochemical changes following antidepressant treatment.

1985 • 10 citations

A calcium hypothesis of antidepressant action

1983 • 8 citations

Chronic administration of a glycine partial agonist alters the expression of N-methyl-D-aspartate receptor subunit mRNAs.

1997 • 8 citations

Respiratory actions of the cardiac glycoside, ouabain

1970 • 6 citations

Calcium and electroconvulsive therapy of depressed patients.

1979 • 5 citations