Mechanisms of N-methyl-D-aspartate-induced apoptosis in phencyclidine-treated cultured forebrain neurons.
Data up to Jan 2025
Total Citations Per Year
Abstract
References (43)
Recent advances in the phencyclidine model of schizophrenia
1991 • 2,886 citations
Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes
1992 • 2,527 citations
Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.
1983 • 2,376 citations
The mitochondrial permeability transition pore and its role in cell death
1999 • 2,326 citations
Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
1995 • 1,892 citations
Excitatory amino acid neurotoxicity and neurodegenerative disease
1990 • 1,781 citations
BCL-2 FAMILY: Regulators of Cell Death
1998 • 1,687 citations
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
1998 • 872 citations
NMDA Antagonist Neurotoxicity: Mechanism and Prevention
1991 • 837 citations
Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate
1995 • 779 citations
Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
1995 • 773 citations
Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation
1996 • 760 citations
Ethanol withdrawal seizures and the NMDA receptor complex
1990 • 444 citations
bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS
1994 • 432 citations
Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins
1998 • 421 citations
Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons
1999 • 384 citations
Mechanisms of excitotoxicity in neurologic diseases
1992 • 382 citations
Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum
1997 • 339 citations
Bax Involvement in p53-Mediated Neuronal Cell Death
1998 • 337 citations
bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.
1995 • 289 citations
NMDA Receptor Activation Produces Concurrent Generation of Nitric Oxide and Reactive Oxygen Species: Implications for Cell Death
1995 • 280 citations
Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1
1999 • 266 citations
1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo.
1985 • 224 citations
Mitochondria and neuronal glutamate excitotoxicity
1998 • 178 citations
Micromolar l-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones
1998 • 173 citations
Neuropharmacology of Phencyclidine: Basic Mechanisms and Therapeutic Potential
1990 • 160 citations
Activity-dependent mobilization of the adhesion molecule polysialic NCAM to the cell surface of neurons and endocrine cells.
1994 • 152 citations
Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons
1996 • 147 citations
Glutamate-dopamine interactions in the basal ganglia: relationship to Parkinson's disease
1993 • 135 citations
NMDA and Kainate Induce Internucleosomal DNA Cleavage Associated With Both Apoptotic and Necrotic Cell Death in the Neonatal Rat Brain
1995 • 130 citations
Induction of tumour‐suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids
1998 • 106 citations
Chronic phencyclidine induces behavioral sensitization and apoptotic cell death in the olfactory and piriform cortex
1998 • 92 citations
Phencyclidine induction of the hsp70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels
1994 • 89 citations
Up-regulation of N-methyl-D-aspartate receptors on cultured cortical neurons after exposure to antagonists.
1992 • 84 citations
Hydrogen peroxide induces nuclear translocation of p53 and apoptosis in cells of oligodendroglia origin
1999 • 84 citations
Glutamate neurotoxicity in mouse cortical neurons: atypical necrosis with DNA ladders and chromatin condensation
1998 • 72 citations
Chronic phencyclidine increases NMDA receptor NR1 subunit mRNA in rat forebrain
1999 • 56 citations
NMDA induces apoptosis and necrosis in neuronal cultures. Increased APP immunoreactivity is linked to apoptotic cells
1997 • 48 citations
Expression of N-methyl- d-aspartate glutamate receptor subunits in the prefrontal cortex of the rat
1996 • 48 citations
Augmentation of locomotor activity by chronic phencyclidine is associated with an increase in striatal NMDA receptor function and an upregulation of the NR1 receptor subunit
1999 • 46 citations
Glycine site of the excitatory amino acid N-methyl-D-aspartate receptor in neonatal and adult brain.
1993 • 39 citations
N-methyl-D-aspartate receptors and Alzheimer's disease
1989 • 38 citations
Effects on ethanol withdrawal hyperexcitability of chronic treatment with a competitive N-methyl-D-aspartate receptor antagonist.
1995 • 27 citations