Clinical pharmacodynamics of continuous infusion topotecan in children: systemic exposure predicts hematologic toxicity.

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

Applied pharmacokinetics : principles of therapeutic drug monitoring

1992 • 1,030 citations

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

1988 • 843 citations

The Current Status of Camptothecin Analogues as Antitumor Agents

1993 • 614 citations

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

1992 • 373 citations

Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors

1992 • 231 citations

DNA topoisomerase I and II in cancer chemotherapy: update and perspectives

1993 • 174 citations

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

1986 • 158 citations

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

1986 • 142 citations

Phase I Clinical and Pharmacology Study of Topotecan Given Daily for 5 Consecutive Days to Patients With Advanced Solid Tumors, With Attempt at Dose Intensification Using Recombinant Granulocyte Colony-Stimulating Factor

1993 • 135 citations

Phase I study of topotecan for pediatric patients with malignant solid tumors.

1994 • 132 citations

Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer.

1992 • 128 citations

A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor topotecan (SK&F 104864) given as an intravenous bolus every 21 days

1992 • 112 citations

High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma

1990 • 104 citations

Plasma and cerebrospinal fluid pharmacokinetic study of topotecan in nonhuman primates.

1993 • 96 citations

Pediatric phase I trial and pharmacokinetic study of topotecan administered as a 24-hour continuous infusion.

1993 • 93 citations

Clinical pharmacokinetics and pharmacodynamics of anticancer drugs in children.

1993 • 42 citations

Pharmacokinetic Optimisation of Anticancer Therapy

1991 • 35 citations

Inhibition of DNA synthesis and DNA fragmentation in stimulated splenocytes by the concerted action of topoisomerase I and II poisons

1993 • 18 citations

In vivo binding characteristics of carbamazepine and carbamazepine-10, 11-epoxide to serum proteins in paediatric patients with epilepsy

1993 • 11 citations