Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

1989 • 645 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

1991 • 513 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

A specific chromosomal abnormality in rhabdomyosarcoma

1987 • 326 citations

Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer.

1972 • 271 citations

Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880).

1970 • 246 citations

Prolonged administration of oral etoposide in patients with relapsed or refractory small-cell lung cancer: a phase II trial.

1990 • 217 citations

The S-phase cytotoxicity of camptothecin

1991 • 190 citations

Rodent tumor models in experimental cancer therapy

1988 • 165 citations

Treatment of malignant melanoma with camptothecin (NSC-100880).

1972 • 158 citations

SCHEDULE DEPENDENCY OF THE ANTILEUKEMIC ACTIVITY OF THE PODOPHYLLOTOXIN‐DERIVATIVE VP 16–213 (NSC‐141540) IN L1210 LEUKEMIA

1973 • 148 citations

Phase II testing of melphalan in children with newly diagnosed rhabdomyosarcoma: a model for anticancer drug development.

1988 • 112 citations

High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma

1990 • 104 citations

Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice

1978 • 88 citations

Characterization of cell lines derived from xenografts of childhood rhabdomyosarcoma.

1987 • 82 citations

Growth characteristics of human colorectal tumours during serial passage in immune-deprived mice

1978 • 62 citations

On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice

1980 • 58 citations

In situ selection of a human rhabdomyosarcoma resistant to vincristine with altered beta-tubulins.

1985 • 46 citations

Growth and characterization of childhood rhabdomyosarcomas as xenografts.

1982 • 45 citations

Evaluation of N-(5-indanylsulfonyl)-N?-(4-chlorophenyl)-urea against xenografts of pediatric rhabdomyosarcoma

1989 • 43 citations

Melphalan: a potential new agent in the treatment of childhood rhabdomyosarcoma.

1985 • 37 citations

Childhood rhabdomyosarcoma xenografts: Responses to DNA-interacting agents and agents used in current clinical therapy

1984 • 35 citations

Development and characterization of pediatric osteosarcoma xenografts.

1990 • 28 citations

Reciprocal cross-resistance in human rhabdomyosarcomas selected in vivo for primary resistance to vincristine and L-phenylalanine mustard.

1987 • 28 citations

Rhabdomyosarcoma: From the Laboratory to the Clinic

1991 • 18 citations

Accumulation, Intracellular Metabolism, and Antitumor Activity of High- and Low-Dose Methotrexate in Human Osteosarcoma Xenografts

1990 • 5 citations