Growth-condition-dependent regulation of insulin-like growth factor II mRNA stability

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

mRNA stability in mammalian cells

1995 • 1,258 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Messenger RNA degradation in eukaryotes

1993 • 858 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Degradation of mRNA in eukaryotes

1995 • 648 citations

When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

1995 • 515 citations

Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin

1988 • 345 citations

The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors.

1991 • 297 citations

A 32-kilodalton protein binds to AU-rich domains in the 3' untranslated regions of rapidly degraded mRNAs.

1991 • 268 citations

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.

1994 • 257 citations

Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs

1987 • 206 citations

Multiple regulatory steps control histone mRNA concentrations

1988 • 199 citations

Regulation of mRNA turnover in eukaryotic cells.

1991 • 171 citations

Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

1995 • 165 citations

Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation.

1994 • 147 citations

The gene structure of the insulin-like growth factor family

1989 • 143 citations

Translational discrimination of mRNAs coding for human insulin-like growth factor II.

1990 • 108 citations

Autogenous Regulation of Histone mRNA Decay by Histone Proteins in a Cell-Free System

1987 • 82 citations

A 32-Kilodalton Protein Binds to AU-Rich Domains in the 3′ Untranslated Regions of Rapidly Degraded mRNAs

1991 • 81 citations

Endonucleolysis in the turnover of insulin-like growth factor II mRNA.

1992 • 73 citations

Long-Range RNA Interaction of Two Sequence Elements Required for Endonucleolytic Cleavage of Human Insulin-Like Growth Factor II mRNAs

1995 • 55 citations

Specific endonucleolytic cleavage of IGF-II mRNAs

1991 • 52 citations

Site-specific cleavage of IGF-II mRNAs requires sequence elements from two distinct regions of the IGF-II gene

1992 • 51 citations

A rapid method for determining the molecular weight of a protein bound to nucleic acid in a mobility shift assay

1992 • 31 citations

Differential polysomal localization of human insulin‐like‐growth‐factor‐2 mRNAs in cell lines and foetal liver

1994 • 29 citations

Elements required for activation of the major promoter of the human insulin-like growth factor II gene

1992 • 22 citations

The cis-acting elements involved in endonucleolytic cleavage of the 3' UTR of human IGF-II mRNAs bind a 50 kDa protein

1996 • 14 citations