Electrophysiology of the Peripheral Myelinated Nerve

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

“Gray's Anatomy”

1985 • 4,681 citations

The effect of sodium ions on the electrical activity of the giant axon of the squid

1949 • 3,479 citations

POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES

1943 • 2,733 citations

Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo

1952 • 2,384 citations

The action of calcium on the electrical properties of squid axons

1957 • 1,853 citations

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

The dual effect of membrane potential on sodium conductance in the giant axon of Loligo

1952 • 1,551 citations

The components of membrane conductance in the giant axon of Loligo

1952 • 1,359 citations

A theory of the effects of fibre size in medullated nerve

1951 • 1,036 citations

Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

1971 • 930 citations

The Structure and Function of Nervous Tissue

1972 • 905 citations

Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena.

1966 • 809 citations

Electrogenic sodium pump in nerve and muscle cells.

1972 • 787 citations

The discharge of impulses in motor nerve fibres

1929 • 757 citations

The Permeability of the Sodium Channel to Organic Cations in Myelinated Nerve

1971 • 751 citations

The action potential in the myelinated nerve fibre of Xenopus laevis as computed on the basis of voltage clamp data

1964 • 694 citations

Currents Related to Movement of the Gating Particles of the Sodium Channels

1973 • 664 citations

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

1973 • 660 citations

Evidence for saltatory conduction in peripheral myelinated nerve fibres

1949 • 617 citations

Excitability changes in afferent fibre terminations and their relation to slow potentials

1958 • 612 citations

Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pH

1975 • 599 citations

The Conduction of the Nervous Impulse.

1918 • 597 citations

Electrochemical aspects of physiological and pharmacological action in excitable cells. I. The resting cell and its alteration by extrinsic factors.

1958 • 579 citations

Charges and Potentials at the Nerve Surface

1968 • 567 citations

A study of nerve physiology.

1947 • 547 citations

The Conduction of the Nervous Impulse

1965 • 538 citations

Electrical Signs of Nervous Activity

1937 • 518 citations

The Selective Inhibition of Delayed Potassium Currents in Nerve by Tetraethylammonium Ion

1967 • 490 citations

Pharmacological Modifications of the Sodium Channels of Frog Nerve

1968 • 479 citations

Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres

1969 • 462 citations

Potassium Channels in Myelinated Nerve

1973 • 448 citations

The Structure and Function of Nervous Tissue

1969 • 429 citations

Potassium Ion Current in the Squid Giant Axon

1960 • 375 citations

The Permeability of the Sodium Channel to Metal Cations in Myelinated Nerve

1972 • 367 citations

Membrane currents in isolated frog nerve fibre under voltage clamp conditions

1958 • 355 citations

The Molecular Structure and Contact Relationships of Cell Membranes

1960 • 348 citations

The effect of veratridine on excitable membranes of nerve and muscle

2007 • 344 citations

Membranes—A series of advances

1974 • 335 citations

DEMONSTRATION OF TWO STABLE POTENTIAL STATES IN THE SQUID GIANT AXON UNDER TETRAETHYLAMMONIUM CHLORIDE

1957 • 323 citations

Internodal conduction in undissected demyelinated nerve fibres

1972 • 323 citations

Effect of potassium and sodium on resting and action potentials of single myelinated nerve fibres

1951 • 313 citations

The Inner Quaternary Ammonium Ion Receptor in Potassium Channels of the Node of Ranvier

1972 • 302 citations

Biophysics and physiology of excitable membranes

1971 • 290 citations

Electrical Signs of Nervous Activity

1937 • 288 citations

Inferences about Membrane Properties from Electrical Noise Measurements

1972 • 274 citations

A new method for measuring membrane potentials with external electrodes

1954 • 274 citations

Computation of Impulse Conduction in Myelinated Fibers; Theoretical Basis of the Velocity-Diameter Relation

1968 • 270 citations

Ionic selectivity of Na and K channels of nerve membranes.

1975 • 261 citations

The effect of temperature on the sodium and potassium permeability changes in myelinated nerve fibres of Xenopus laevis

1963 • 259 citations

A new voltage clamp method for Ranvier nodes

1969 • 248 citations

A computer simulation of conduction in demyelinated nerve fibres

1972 • 246 citations

II. Experiments in examination of the peripheral distribution the fibres of the posterior roots of some spinal nerves. -Part II

1898 • 241 citations

Electrochemical aspects of physiological and pharmacological action in excitable cells. II. The action potential and excitation.

1958 • 240 citations

The role of calcium ions in neural processes.

1954 • 232 citations

The discharge of impulses in motor nerve fibres

1928 • 229 citations

Sodium currents in the myelinated nerve fibre of Xenopus laevis investigated with the voltage clamp technique

1959 • 226 citations

Quantitative description of sodium currents in myelinated nerve fibres of Xenopus laevis

1960 • 223 citations

Common Mode of Action of Three Agents that Decrease the Transient Change in Sodium Permeability in Nerves

1966 • 219 citations

Computation of Impulse Initiation and Saltatory Conduction in a Myelinated Nerve Fiber

1962 • 215 citations

New Measurements of the Capacity and the Resistance of the Myelin Sheath and the Nodal Membrane of the Isolated Frog Nerve Fiber

1955 • 215 citations

Conduction velocity and myelin thickness in regenerating nerve fibres

1946 • 213 citations

The origin of the initial heat associated with a single impulse in mammalian non‐myelinated nerve fibres

1968 • 205 citations

Myelinated nerve fibers: computed effect of myelin thickness on conduction velocity

1970 • 205 citations

Actions of saxitoxin on peripheral neuromuscular systems.

1965 • 200 citations

THE CONDUCTION OF THE NERVE IMPULSE

1926 • 199 citations

Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom.

1975 • 194 citations

The origin of vestibulospinal fibres in the cat. An experimental-anatomical study, with comments on the descending medial longitudinal fasciculus

1957 • 193 citations

Direct determination of membrane resting potential and action potential in single myelinated nerve fibres

1951 • 173 citations

Tetrodotoxin, Saxitoxin, and Related Substances: Their Applications in Neurobiology

1972 • 172 citations

On the active structure of local anesthetics.

1961 • 168 citations

Laboratory Techniques in Membrane Biophysics

1969 • 167 citations

Specialized paranodal and interparanodal glial-axonal junctions in the peripheral and central nervous system: A freeze-etching study

1973 • 162 citations

FACTORS AFFECTING TRANSMISSION AND RECOVERY IN THE PASSIVE IRON NERVE MODEL

1925 • 156 citations

THE MEMBRANOUS COVERINGS OF NEURAL TISSUES

1967 • 151 citations

The histological fine structure of perineurium

1967 • 148 citations

The movements of labelled ions in mammalian non‐myelinated nerve fibres.

1965 • 147 citations

Demonstration of two stable states of the nerve membrane in potassium‐rich media

1959 • 141 citations

Die Wirkung von Skorpiongift auf die Ionenstr�me des Ranvierschen Schn�rrings

1968 • 138 citations

A quantitative description of potassium currents in myelinated nerve fibres of Xenopus laevis

1963 • 122 citations

Specific and unspecific charges at the sodium channels of the nerve membrane

1974 • 120 citations

Bau und Funktion isolierter markhaltiger Nervenfasern

1952 • 119 citations

Molecular mechanisms of anesthesia

1975 • 114 citations

Displacement currents in the node of Ranvier

1975 • 111 citations

Energetic aspects of nerve conduction: The relationships between heat production, electrical activity and metabolism

1973 • 110 citations

Effect of Surface Charge on the Steady-state Potassium Conductance of Nodal Membrane

1970 • 108 citations

The rate of action of tetrodotoxin on myelinated nerve fibres of Xenopus laevis and Rana esculenta

1973 • 106 citations

Die Signalübermittlung im Nerven

1945 • 101 citations

Effect of aconitine on the sodium permeability of the node of ranvier

1974 • 101 citations

Potassium permeability in myelinated nerve fibres of Xenopus laevis

1962 • 100 citations

A method for recording resting and action potentials in the isolated myelinated nerve fibre of the frog

1957 • 99 citations

Sodium permeability in toad nerve and in squid nerve

1960 • 98 citations

Preliminary observations on the ultrastructure of nodes of Ranvier

1959 • 96 citations

The effect of the nerve sheath on the action of local anesthetics.

1965 • 95 citations

Delayed currents in myelinated nerve fibres of Xenopus laevis investigated with voltage clamp technique

1962 • 95 citations

Potassium inactivation in single myelinated nerve fibres of Xenopus laevis

1971 • 94 citations

Bau und Funktion isolierter markhaltiger Nervenfasern

2008 • 94 citations

Recovery Processes and Metabolism of Nerve

1959 • 91 citations

The local chemical environment of nodes of Ranvier: a study of cation binding.

1971 • 91 citations

Die Wirkung von Skorpiongift auf die Ionenstr�me des Ranvierschen Schn�rrings

1968 • 88 citations

Saltatory Conduction in Nerve

1954 • 88 citations

IS THE RESTING POTENTIAL OF RANVIER NODES A POTASSIUM POTENTIAL?*

1959 • 86 citations

Ultrastructure of the Node of Ranvier

1963 • 82 citations

Local Anesthetics: Effects on Permeability Properties of Nodal Membrane in Myelinated Nerve Fibres from Xenopus. Potential Clamp Experiments

1974 • 80 citations

Penetration of peroxidase into peripheral nerve fibers

1973 • 80 citations

Steady state inactivation of sodium permeability in myelinated nerve fibres of Xenopus laevis

1959 • 77 citations

The effect of reducing extracellular pH on the membrane currents of the Ranvier node

1969 • 75 citations

Increase of sodium concentration near the inner surface of the nodal membrane

1970 • 75 citations

Calcium and lanthanum effects at the nodal membrane

1974 • 73 citations

Die Wirkung von Tetra�thylammoniumchlorid auf die Membranstr�me Ranvierscher Schn�rringe von Xenopus laevis

1967 • 72 citations

Measurement of the Action Potential of Myelinated Nerve Fiber

1955 • 70 citations

Wirkung von Tetrodotoxin und Tetra�thylammoniumchlorid an der Innenseite der Schn�rringsmembran vonXenopus laevis

1969 • 69 citations

Der am Ranvierschen Knoten entstehende Aktionsstrom und seine Bedeutung für die Erregungsleitung

1941 • 69 citations

Weitere Studien über den Aktionsstrom der markhaltigen Nervenfaser und über die elektrosaltatorische Übertragung des Nervenimpulses

1942 • 67 citations

Conduction velocity in myelinated nerve fibres of Xenopus laevis

1970 • 67 citations

The Problem of Excitability

1974 • 64 citations

Die Wirkung von Tetra�thylammoniumchlorid auf den einzelnen Ranvierschen Schn�rring

1966 • 63 citations

Instantaneous potassium currents in myelinated nerve fibres of Xenopus laevis

1962 • 61 citations

Membrane shot-noise in electrically depolarized nodes of Ranvier

1973 • 58 citations

THE STRENGTH-DURATION RELATION OF THE NORMAL, POLARIZED AND NARCOTIZED NERVE FIBER

1939 • 57 citations

Characteristics of the sodium gating current in the squid giant axon.

1973 • 56 citations

Turnover of Basic Protein of Rat Brain

1971 • 56 citations

Effects of Ionic Concentration on Permeability Properties of Nodal Membrane in Myelinated Nerve Fibres of Xenopus laevis. Potential Clamp Experiments

1973 • 54 citations

Axon membrane voltage fluctuations.

1965 • 53 citations

COMPARATIVE OBSERVATIONS ON MOTOR AND SENSORY FIBERS WITH SPECIAL REFERENCE TO REPETITIOUSNESS

1938 • 52 citations

Restoration of Sodium-deficient Frog Nerve Fibres by Onium Ions

1957 • 52 citations

The specificity of the initial current in myelinated nerve fibres of Xenopus laevis. Voltage clamp experiments

1963 • 49 citations

Intraaxonal iodate inhibits sodium inactivation

1974 • 49 citations

The microphysiology of nerve

1950 • 49 citations

Voltage clamp studies of veratrinized frog nodes

1965 • 47 citations

Inactivation of the sodium‐carrying mechanism in myelinated nerve fibres of Xenopus laevis

1963 • 46 citations

PHYSIOLOGICAL AND BIOCHEMICAL CHANGES IN FROG SCIATIC NERVE DURING ANOXIA AND RECOVERY¹

1971 • 45 citations

Movements in the Myelin Schwann Sheath of the Vertebrate Axon

1969 • 44 citations

THE HYPOTHESIS OF SALTATORY CONDUCTION

1952 • 44 citations

THE PARALLELISM BETWEEN THE ACTION POTENTIAL, ACTION CURRENT, AND MEMBRANE RESISTANCE AT A NODE OF RANVIER

1955 • 43 citations

Restoration of Sodium-deficient Frog Nerve Fibres by an Isotonic Solution of Guanidinium Chloride

1956 • 40 citations

Unusual Sky Appearance

1935 • 39 citations

The heat production of nerve

1936 • 39 citations

MANIFESTATIONS OF SEGMENTATION IN MYELINATED AXONS

1934 • 38 citations

Experiments on the phenomenon of paralysis produced by a toxin occurring in Triturus embryos

1937 • 38 citations

VERTICAL NYSTAGMUS FOLLOWING LESIONS OF THE CEREBELLAR VERMIS

1941 • 38 citations

Sustained spontaneous activity of ranvier nodes induced by the combined actions of TEA and lack of calcium

1968 • 37 citations

Feather Mites and Ornithosis

1960 • 36 citations

After-Potentials and Large Depolarizations of Single Nodes of Ranvier Treated with Veratridine

1965 • 36 citations

Effect of temperature and calcium ions on rate constants of myelinated nerve

1971 • 35 citations

Die Nachpotentiale isolierter markhaltiger Nervenfasern des Frosches bei Einzelreizung

1960 • 34 citations

ON THE EXCITATION, CONDUCTION, AND NARCOTISATION OF SINGLE NERVE FIBRES

1936 • 34 citations

A Pharmacological Analysis of the Ionic Channels of Nerve

1967 • 34 citations

Computed action potential in nerve from Xenopus laevis.

1965 • 34 citations

CURRENT-VOLTAGE RELATIONS OF SINGLE NODES OF RANVIER AS EXAMINED BY VOLTAGE-CLAMP TECHNIQUE

1958 • 32 citations

‘Intercalated’ Internodes in Nerve Fibres

1958 • 30 citations

Ionic Currents at Resting Potential in Nerve Fibres from Xenopus laevis. Potential Clamp Experiments

1973 • 30 citations

Rate of veratridine action on the nodal membrane

1972 • 29 citations

Modification of ionic membrane currents of ranvier nodes by UV-radiation under voltage clamp conditions

1971 • 28 citations

Influence of calcium ions on the ionic currents of nodes of Ranvier treated with scorpion venom

1972 • 28 citations

Drugs and Nerve Conduction

1963 • 28 citations

Amplitude distribution of axon membrane noise voltage.

1969 • 27 citations

Tetraethylammonium ion inhibition of potassium conductance of the nodal membrane

1972 • 25 citations

[Effect of surface charge on the stationary potassium conductivity of Ranvier's node membrane. I. Change in pH of the external solution].

1972 • 25 citations

Voltage threshold in excitable cells depends on stimulus form.

1970 • 24 citations

Posttetanic changes in membrane potential of single medullated nerve fibers

1973 • 24 citations

Slow sodium inactivation in the Ranvier node membrane role of external potassium

1973 • 23 citations

Dissection of Single Nerve Fibres and Measurement of Membrane Potential Changes of Ranvier Nodes by means of the Double Air Gap Method

1969 • 23 citations

Rate of action of tetraethylammonium ions on the duration of action potentials in single Ranvier nodes

1971 • 23 citations

Effect of a sudden change in sodium concentration on repetitively evoked action potentials of single nodes of Ranvier

1971 • 22 citations

Propagation Speed in Myelinated Nerve

1973 • 22 citations

Myelin movements in mature mammalian peripheral nerve fibers

1974 • 21 citations

The Effect of Calcium on the Potassium Permeability in the Myelinated Nerve Fibre of Xenopus Laevis

1972 • 21 citations

EFFECTS OF POTASSIUM, SODIUM, AND AZIDE ON THE IONIC MOVEMENTS THAT ACCOMPANY ACTIVITY IN FROG NERVES

1958 • 20 citations

The Problem of Excitability: Electrical Excitability and Ionic Permeability of the Nerve Membrane

1974 • 18 citations

Rate of veratridine action on the nodal membrane

1972 • 18 citations

A quantitative electron microscope analysis of peripheral nerve in the urodele amphibian in relation to limb regenerative capacity

1971 • 18 citations

Effect of temperature on the slowly changing sodium permeability of veratrinized nodes of ranvier

1969 • 18 citations

A New Voltage Clamp Method

1969 • 18 citations

Die Wirkung von Tetra�thylammoniumchlorid auf das Membranpotential und den Membranwiderstand von B�ndeln markhaltiger Nervenfasern

1965 • 17 citations

Weitere Untersuchungen �ber den passiven Ionentransport durch die erregbare Membran des Ranvierknotens

1961 • 16 citations

[Effect of surface charge on stationary potassium conductance of Ranvier's node membrane. 3. Effect of divalent cations].

1972 • 14 citations

Notizen: Sprunghafte Schwankungen unterschwelliger Potentiale an markhaltigen Nervenfasern

1958 • 14 citations

Membrane Currents in Clamped Vertebrate Nerve

1957 • 14 citations

Membrane currents at large positive internal potentials in single myelinated nerve fibres of rana pipiens

1967 • 13 citations

Convergence of Inputs on Deiters Neurones

1966 • 13 citations

Salicylate: effects on ion transport and afterpotentials in frog sciatic nerve

1965 • 10 citations

Some Effects of Calcium Ions on the Action Potential of Single Nodes of Ranvier

1964 • 10 citations

Morphologische Ver�nderungen des �berlebenden Ranvierschen Schn�rrings unter Einwirkung anisosmotischer Aussenl�sungen

1959 • 9 citations

[The effect of surface charge on stationary potassium conductivity of the membrane of a node of Ranvier. II. Changes in the ion strength of the external solution].

1972 • 8 citations

Messung des Calcium-Einflusses auf die Strom-Spannungsbeziehung der erregbaren Membran am Ranvier-Knoten

1968 • 8 citations

Das Aktionspotential des isolierten Ranvierschen Schn�rrings bei Erh�hung der extracellul�ren Wasserstoffionen-Konzentration in calciumhaltigen und calciumarmen L�sungen

1962 • 7 citations

[Kinetics of the process of inactivation of sodium channels in frog Ranvier's nodes].

1973 • 7 citations

Der Einfluss elektrophysiologisch wirksamer Substanzen auf das mikroskopische Bild des �berlebenden Ranvierschen Schn�rrings

1960 • 7 citations

Die repetitive Aktivit�t motorischer und sensibler markhaltiger Nervenfasern des Frosches

1968 • 7 citations

Simulated responses of depressed and hyperpolarized medullated nerve fibers

1969 • 6 citations

Untersuchungen am Ranvierschen Schn�rring einzelner Taubennervenfasern

1970 • 5 citations

[Interrelations of the processes of sodium activation and inactivation].

1973 • 4 citations

Factors controlling simulated responses of medullated nerve fibers

1970 • 4 citations

Strukturver�nderungen des Ranvierschen Schn�rrings w�hrend des Elektrotonus und w�hrend der funktionellen Zerst�rung

1961 • 3 citations

[Potassium stationary-state conductance of Ranvier's node membrane in the presence of La3+, Zn2+ and Cu2+ in the external medium].

1973 • 3 citations

Neurogenic control of thrombolysis

1967 • 3 citations

[Analysis of a mathematical model of plant water exchange system].

1967 • 2 citations

Membrane properties of Ranvier nodes from South American toads frogs (Bufo marinus ictericus and Leptodactylus ocellatus)

1973 • 1 citations