Energetic aspects of nerve conduction: The relationships between heat production, electrical activity and metabolism

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

Theory of dielectrics

1949 • 2,245 citations

Enzymatic Basis for Active Transport of Na⁺ and K⁺ Across Cell Membrane

1965 • 2,008 citations

Ionic processes in solution

1953 • 835 citations

Active transport of cations in giant axons from Sepia and Loligo

1955 • 774 citations

Ionic processes in solution

1953 • 751 citations

Movements of labelled calcium in squid giant axons

1957 • 668 citations

The Regulation of Glycolysis and Gluconeogenesis in Animal Tissues

1968 • 635 citations

The Conduction of the Nervous Impulse.

1918 • 597 citations

The Energy-linked Reaction of Calcium with Mitochondria

1965 • 556 citations

The effect of temperature on the electrical activity of the giant axon of the squid

1949 • 555 citations

The Conduction of the Nervous Impulse

1965 • 538 citations

Chemical and Molecular Basis of Nerve Activity

1975 • 480 citations

Light Scattering and Birefringence Changes during Nerve Activity

1968 • 472 citations

On the electrogenic sodium pump in mammalian non‐myelinated nerve fibres and its activation by various external cations

1968 • 430 citations

Factors Affecting the Activity of Muscle Phosphorylase b Kinase

1959 • 418 citations

Ionic channels in nerve membranes

1970 • 416 citations

EXTRACELLULAR SPACE AS A PATHWAY FOR EXCHANGE BETWEEN BLOOD AND NEURONS IN THE CENTRAL NERVOUS SYSTEM OF THE LEECH: IONIC COMPOSITION OF GLIAL CELLS AND NEURONS

1964 • 325 citations

The effects of injecting ‘energy‐rich’ phosphate compounds on the active transport of ions in the giant axons of Loligo

1960 • 322 citations

The Rate of Action of Drugs on Cells

1937 • 319 citations

Chemical and Molecular Basis of Nerve Activity

1960 • 304 citations

The hyperpolarization which follows activity in mammalian non‐medullated fibres

1957 • 265 citations

The Mode of Action of Drugs on Cells.

1933 • 258 citations

Opacity changes in stimulated nerve

1949 • 251 citations

Membrane current and intracellular sodium changes in a snail neurone during extrusion of injected sodium

1969 • 250 citations

The sodium and potassium content of cephalopod nerve fibres

1951 • 215 citations

OLFACTORY NERVE FIBERS

1956 • 208 citations

The binding of labelled tetrodotoxin to non‐myelinated nerve fibres

1972 • 206 citations

The origin of the initial heat associated with a single impulse in mammalian non‐myelinated nerve fibres

1968 • 205 citations

Enzymatic aspects of active linked transport of Na+ and K+ through the cell membrane

1964 • 204 citations

Binding of the cardiac glycoside ouabain to intact cells

1972 • 198 citations

An electrogenic sodium pump in snail nerve cells

1965 • 186 citations

TRAILS AND TRIALS IN PHYSIOLOGY

1965 • 176 citations

Trails and Trials in Physiology

1965 • 165 citations

An upper limit to the number of sodium channels in nerve membrane?

1967 • 163 citations

The movements of labelled ions in mammalian non‐myelinated nerve fibres.

1965 • 147 citations

Sodium Fluxes in Internally Dialyzed Squid Axons

1968 • 142 citations

The Interaction between Tritiated Ouabain and the Na-K Pump in Red Blood Cells

1969 • 140 citations

The volume change resulting from stimulation of a giant nerve fibre

1950 • 137 citations

Changes in Fluorescence in a Frog Sartorius Muscle Following a Twitch

1959 • 135 citations

The oxygen consumption of mammalian non‐myelinated nerve fibres at rest and during activity

1967 • 117 citations

Equilibrium and Kinetic Properties of the Interaction between Tetrodotoxin and the Excitable Membrane of the Squid Giant Axon

1970 • 116 citations

Changes in axon birefringence during the action potential

1970 • 112 citations

Phosphorus metabolism of intact crab nerve and its relation to the active transport of ions.

1965 • 106 citations

Some properties of the external activation site of the sodium pump in crab nerve

1966 • 100 citations

Changes in light scattering that accompany the action potential in squid giant axons: potential‐dependent components

1972 • 97 citations

The binding of tetrodotoxin to nerve membranes

1971 • 95 citations

Analysis of the potential‐dependent changes in optical retardation in the squid giant axon

1971 • 94 citations

Changes in light scattering associated with the action potential in crab nerves

1971 • 91 citations

Measurement of axonal membrane conductances and capacity by means of a varying potential control voltage clamp

1969 • 91 citations

Recovery Processes and Metabolism of Nerve

1959 • 91 citations

STUDIES ON NERVE METABOLISM

1927 • 80 citations

The distribution of Na and K in cat nerves

1955 • 74 citations

On the control of glycogenolysis in mammalian nervous tissue by calcium

1971 • 69 citations

Changes in axon light scattering that accompany the action potential: current‐dependent components

1972 • 68 citations

On the number of sodium pumping sites in cell membranes

1969 • 66 citations

A comparison of the effect of temperature, metabolic inhibitors and of ouabain on the electrogenic component of the sodium pump in mammalian non‐myelinated nerve fibres

1969 • 66 citations

The interaction at equilibrium between tetrodotoxin and mammalian non‐myelinated nerve fibres

1972 • 64 citations

Binding of Tritiated Digoxin to Human Red Cell Ghosts

1969 • 64 citations

The after‐effects of repetitive stimulation on mammalian non‐medullated fibres

1956 • 61 citations

Optical studies of biochemical events in the electric organ ofElectrophorus

1964 • 60 citations

Light scattering and birefringence changes during activity in the electric organ of Electrophorus electricus

1969 • 59 citations

The permeability of the squid giant axon to radioactive potassium and chloride ions

1960 • 59 citations

The effect of stimulation on the opacity of a crustacean nerve trunk and its relation to fibre diameter

1950 • 58 citations

METABOLIC REQUIREMENTS OF SYMPATHETIC NEURONS

1952 • 57 citations

The binding of tritiated ouabain to mammalian non‐myelinated nerve fibres

1970 • 56 citations

Sequence of Steps in the (Na + K)-Activated Enzyme System in Relation to Sodium and Potassium Transport

1971 • 54 citations

The effects of activity on mammalian nerve fibres of low conduction velocity

1956 • 50 citations

Partial excitation and variable conduction in the squid giant axon

1940 • 50 citations

Effect of frequency of electrical stimulation on the concentration of intermediary metabolites in mammalian non‐myelinated fibres

1959 • 49 citations

The heat production of nerve

1926 • 47 citations

Heat studies in excitable tissues.

1973 • 42 citations

Impulses at the Artifactual Nerve End

1965 • 39 citations

The heat production of nerve

1936 • 39 citations

The dependence on external cations of the oxygen consumption of mammalian non‐myelinated fibres at rest and during activity

1968 • 38 citations

The initial heat production associated with the nerve impulse in crustacean and mammalian non‐myelinated nerve fibres

1965 • 37 citations

The ionic content of mammalian non‐myelinated nerve fibres and its alteration as a result of electrical activity

1968 • 34 citations

Glycolytic Control Mechanisms

1967 • 33 citations

Moving-Coil Galvanometers of Short Period and their Amplification

1948 • 32 citations

Glycolytic Control Mechanisms

1967 • 31 citations

Metabolic studies on the hyperpolarization following activity in mammalian non‐myelinated nerve fibres

1962 • 28 citations

Optical studies on the kinetics of the sodium pump in mammalian non‐myelinated nerve fibres

1971 • 27 citations

On the metabolic basis of nervous activity

1969 • 26 citations

Untersuchungen zur Thermodynamik der bioelektrischen Ströme

1906 • 25 citations

EFFECTS OF POTASSIUM, SODIUM, AND AZIDE ON THE IONIC MOVEMENTS THAT ACCOMPANY ACTIVITY IN FROG NERVES

1958 • 20 citations

Electrogenic Ion Pumping in Nervous Tissue1 1Some of the work reported here was supported by a grant NS-08304 from the U.S. Public Health Service.

1971 • 17 citations

Effect of electrical activity on the concentration of phosphorylated metabolites and inorganic phosphate in mammalian non-myelinated nerve fibres.

1969 • 14 citations

The effect of some quaternary ammonium compounds and local anaesthetics on the electrogenic component of the sodium pump in mammalian non-myelinated nerve fibres

1969 • 12 citations

The temperature changes during and after the discharge of the electric organ in Electrophones electricus

1968 • 12 citations

Bestimmung elektrischer Konstanten von C-Fasern

1963 • 5 citations

The initial heat production of amphibian myelinated nerve fibres.

1970 • 3 citations