Multiple cis- and trans-acting elements involved in regulation of the neu gene.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1986 • 1,150 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen

1987 • 969 citations

The Product of the Human c- erb B-2 Gene: a 185-Kilodalton Glycoprotein with Tyrosine Kinase Activity

1986 • 805 citations

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

1981 • 795 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

1987 • 619 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

The neu Gene: an erb B-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor

1985 • 513 citations

Multiple sequence motifs are involved in SV40 enhancer function.

1986 • 511 citations

A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells

1986 • 408 citations

Characterization of the Promoter Region of the Human Transforming Growth Factor-β1 Gene

1989 • 400 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene.

1985 • 391 citations

p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.

1986 • 341 citations

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line.

1986 • 329 citations

Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion.

1988 • 321 citations

Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas

1982 • 251 citations

Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer

1990 • 233 citations

Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

1988 • 227 citations

Bacterial beta-galactosidase as a marker of Rous sarcoma virus gene expression and replication.

1985 • 206 citations

A v-erbB-related protooncogene, c-erb-B-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma

1985 • 195 citations

Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.

1988 • 186 citations

Overexpression of erbB-2 or EGF receptor proteins present in early stage mammary carcinoma is detected simultaneously in matched primary tumors and regional metastases.

1989 • 160 citations

Enhancers: Mechanisms of Action and Cell Specificity

1988 • 159 citations

Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.

1986 • 158 citations

Epidermal growth factor (EGF) receptor gene transcription. Requirement for Sp1 and an EGF receptor-specific factor.

1988 • 144 citations

Modulation of epidermal growth factor receptor proto-oncogene transcription by a promoter site sensitive to S1 nuclease.

1988 • 143 citations

Oncogenic Activation of p185^neu Stimulates Tyrosine Phosphorylation In Vivo

1988 • 142 citations

Sporadic amplification of the HER2/neu protooncogene in adenocarcinomas of various tissues.

1988 • 134 citations

Epidermal growth factor receptor gene promoter. Deletion analysis and identification of nuclear protein binding sites.

1988 • 127 citations

Characterization of the promoter region of the human insulin receptor gene. Evidence for promoter activity.

1987 • 117 citations

Expression of the c-erbB-2 gene product (p185) at different stages of neoplastic progression in the colon.

1989 • 106 citations

A transcription factor active on the epidermal growth factor receptor gene.

1988 • 102 citations

Amplification and rearrangement of c-erb B proto-oncogenes in cancer of human female genital tract.

1989 • 101 citations

Immunohistochemical detection of the neu protein in tissue sections of human breast tumors with amplified neu DNA.

1988 • 92 citations

Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659----Glu659).

1990 • 91 citations

Characterization of the promoter region of the human c-erbB-2 protooncogene.

1987 • 87 citations

Human HER2 (neu) promoter: evidence for multiple mechanisms for transcriptional initiation.

1987 • 77 citations

Characterization of the Promoter Region and 3′ End of the Human Insulin Receptor Gene

1989 • 74 citations

The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.

1988 • 74 citations

Enhancers and transcription factors in the control of gene expression

1988 • 70 citations

Heterogeneous expression of erbB-2 messenger RNA in human breast cancer.

1989 • 62 citations

Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation.

1989 • 52 citations

Transcript maps of Drosophila yolk protein genes

1982 • 38 citations

Multiple Hormone-Inducible Enhancers as Mediators of Differential Transcription

1986 • 29 citations

Multiple hormone-inducible enhancers as mediators of differential transcription.

1986 • 16 citations

Modulation of Epidermal Growth Factor Receptor Proto-Oncogene Transcription by a Promoter Site Sensitive to S1 Nuclease

1988 • 12 citations

Enhancers: Mechanisms Of Action And Cell Specificity

1988 • 11 citations