Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Staphylococcal Protease: A Proteolytic Enzyme Specific for Glutamoyl Bonds

1972 • 703 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.

1983 • 324 citations

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

1984 • 299 citations

Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation.

1982 • 254 citations

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.

1987 • 221 citations

Identification of insulin receptor tyrosine residues autophosphorylated in vitro.

1987 • 182 citations

Autophosphorylation of the insulin receptor in vitro. Designation of phosphorylation sites and correlation with receptor kinase activation.

1986 • 158 citations

Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro.

1985 • 151 citations

Phosphorylation of receptors for insulin and insulin-like growth factor I. Effects of hormones and phorbol esters.

1986 • 102 citations

Early events in insulin actions.

1986 • 74 citations

Phosphorylation of synthetic insulin receptor peptides by the insulin receptor kinase and evidence that the preferred sequence containing Tyr-1150 is phosphorylated in vivo.

1986 • 73 citations

Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity

1987 • 66 citations

Molecular Basis of Insulin Action

1986 • 53 citations

Insulin and rabbit anti-insulin receptor antibodies stimulate additively the intrinsic receptor kinase activity.

1987 • 29 citations

Mechanisms of Receptor-mediated Transmembrane Communication

1986 • 28 citations

Epidermal growth factor, but not insulin, stimulates tyrosine phosphorylation of an endogenous protein of Mr 95,000 in triton extracts of human placental syncytiotrophoblast membranes

1987 • 9 citations