HLA Class II–Mediated Death Is Induced Via Fas/Fas Ligand Interactions in Human Splenic B Lymphocytes

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

The Fas Death Factor

1995 • 4,070 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

1995 • 706 citations

Fas ligand in human serum

1996 • 682 citations

Expression of the Fas ligand in cells of T cell lineage.

1995 • 659 citations

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1995 • 656 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Activation interferes with the APO-1 pathway in mature human T cells

1993 • 466 citations

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

1995 • 426 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR

1989 • 388 citations

Identification of mRNAs Associated with Programmed Cell Death in Immature Thymocytes

1991 • 286 citations

Identification of mRNAs associated with programmed cell death in immature thymocytes.

1991 • 242 citations

Activated B cells express functional Fas ligand

1996 • 202 citations

Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation.

1990 • 201 citations

Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells.

1994 • 182 citations

Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion.

1990 • 163 citations

The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation.

1990 • 156 citations

Selection of the T cell receptor repertoire in Lpr mice.

1993 • 155 citations

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

1992 • 130 citations

Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo.

1995 • 123 citations

Lymphocyte programmed cell death is mediated via HLA class II DR

1994 • 111 citations

B cell antigen receptor-mediated apoptosis. Importance of accessory molecules CD19 and CD22, and of surface IgM cross-linking.

1995 • 100 citations

Early biochemical events after MHC class II-mediated signaling on human B lymphocytes.

1990 • 84 citations

CD95 (APO-1/Fas)-associating signalling proteins.

1996 • 76 citations

Anti-IgM antibody-induced cell death in a human B lymphoma cell line, B104, represents a novel programmed cell death.

1992 • 73 citations

APO-1(CD95)-dependent and -independent antigen receptor-induced apoptosis in human T and B cell lines

1995 • 68 citations

Characterization of the non-functional Fas ligand of gld mice

1995 • 67 citations

Comparison of Fas(Apo-1/CD95)- and perforin-mediated cytotoxicity in primary T lymphocytes

1996 • 63 citations

Evidence for dimers of MHC class II molecules in B lymphocytes and their role in low affinity T cell responses

1994 • 62 citations

Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells.

1991 • 57 citations

Defect in negative selection in lpr donor-derived T cells differentiating in non-lpr host thymus.

1991 • 47 citations

Ligation of HLA class II molecules promotes sensitivity to CD95 (Fas antigen, APO‐1)‐mediated apoptosis

1995 • 38 citations

HLA Class II Molecule Signal Transduction Leads to either Apoptosis or Activation via Two Different Pathways

1996 • 34 citations

Protein kinase C (PKC) activation via human leucocyte antigen class II molecules. A novel regulation of PKC activity.

1991 • 28 citations

Detection of empty HLA class II molecules on cord blood B cells

1996 • 23 citations

Bacterial superantigen signaling via HLA class II on human B lymphocytes

1994 • 14 citations