Quantitative high-performance liquid chromatography analysis of DNA oxidized in vitro and in vivo

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

1984 • 941 citations

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

1986 • 933 citations

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1987 • 778 citations

Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis

1990 • 741 citations

The role of 8-hydroxyguanine in carcinogenesis

1990 • 732 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro

1974 • 437 citations

Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA

1987 • 343 citations

Reduced oxygen species, mutation, induction and cancer initiation

1987 • 267 citations

Oxy-radicals in molecular biology and pathology

1989 • 262 citations

Thymine glycols and urea residues in M13 DNA constitute replicative blocksin vitro

1985 • 258 citations

Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane.

1989 • 250 citations

Formation of 8-hydroxyguanine moiety in deoxyribonucleic acid on .gamma.-irradiation in aqueous solution

1985 • 224 citations

Synthesis of 5-Substituted Pyrimidines via Formaldehyde Addition¹

1959 • 210 citations

The Repairability of Oxidative Free Radical Mediated Damage to DNA: A Review

1988 • 196 citations

Formation of 8-hydroxydeoxyguanosine, hydroxyl free radical adduct of DNA in granulocytes exposed to the tumor promoter, tetradeconylphorbolacetate

1986 • 192 citations

Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis

1989 • 189 citations

Further studies on the response of intestinal crypt cells of different hierarchical status to eighteen different cytotoxic agents

1987 • 186 citations

Structural and conformational analyses of 8-hydroxy-2'-deoxyguanosine

1989 • 147 citations

Damage to the bases in DNA induced by stimulated human neutrophils.

1989 • 139 citations

Thymlne glycol lesions terminate chain elongation by DNA polymerase I in vitro

1986 • 133 citations

5,6-Saturated thymine lesions in DNA: production by ultraviolet light or hydrogen peroxide

1982 • 133 citations

Thymine Fragment Damage Retained in the DNA Polynucleotide Chain after Gamma Irradiation in Aerated Solutions. II

1977 • 127 citations

Identification of the cis-thymine glycol moiety in chemically oxidized and .gamma.-irradiated DNA by HPLC analysis

1981 • 117 citations

5-Formyldeoxyuridine: a new type of DNA damage induced by ionizing radiation and its mutagenicity to Salmonella strain TA102

1990 • 114 citations

Quantitative determination of the 5-(hydroxymethyl)uracil moiety in the DNA of .gamma.-irradiated cells

1985 • 108 citations

Possible role for thymine glycol in the selective inhibition of DNA synthesis on oxidized DNA templates.

1985 • 106 citations

Radiation-like modification of bases in DNA exposed to tumor promoter-activated polymorphonuclear leukocytes.

1986 • 106 citations

Sequence dependence for bypass of thymine glycols in DNA by DNA polymerase I

1986 • 101 citations

Hydrogen peroxide formation and DNA base modification by tumor promoter-activated polymorphonuclear leukocytes

1987 • 97 citations

Identification of the cis-thymine glycol moiety in oxidized deoxyribonucleic acid

1981 • 85 citations

Formation of 8-hydroxyguanine residues in cellular DNA exposed to the carcinogen 4-nitroquinoline 1-oxide

1986 • 81 citations

An ab initio molecular orbital study on the characteristics of 8-hydroxyguanine

1987 • 78 citations

Initiation by nickel acetate and promotion by sodium barbital of renal cortical epithelial tumors in male F344 rats

1990 • 78 citations

Identification of Radioproducts Resulting from the Breakage of Thymine Moiety by Gamma Irradiation of E. coli DNA in an Aerated Aqueous Solution

1974 • 77 citations

Genetic effects of 5-hydroxymethyl-2′-deoxyuridine, a product of ionizing radiation

1987 • 68 citations

Nitrogen-15 nuclear magnetic resonance studies on the tautomerism of 8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine, and other C8-substituted guanine nucleosides

1990 • 67 citations

Oxidation of DNA bases by tumor promoter-activated processes.

1989 • 66 citations

Radiation Carcinogenesis and DNA Alterations

1986 • 60 citations

Quantitative Measurement of the Diastereoisomers of CIS Thymidine Glycol in Gamma-Irradiated DNA

1987 • 50 citations

Effects of metals on nucleoside hydroperoxide, a product of ionizing radiation in DNA

1989 • 36 citations

Detection by ³²P-postlabeling of thymidine glycol in γ-irradiated DNA

1989 • 36 citations

Comparison of the mutagenic activity of 5-hydroxymethyldeoxyuridine with 5-substituted 2′-deoxyuridine analogs in the Ames Salmonella/microsome test

1986 • 33 citations

Mutagenicity of 5-hydroxymethyl-2'-deoxyuridine to Chinese hamster cells.

1988 • 33 citations