A pilot study of interferon alfa-2a in combination with fluorouracil plus high-dose leucovorin in metastatic gastrointestinal carcinoma.

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Toxicity and response criteria of the Eastern Cooperative Oncology Group

1982 • 10,605 citations

Evaluation of survival data and two new rank order statistics arising in its consideration.

1966 • 7,595 citations

Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.

1989 • 911 citations

The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group.

1989 • 561 citations

A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma.

1988 • 513 citations

Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil and high-dose folinic acid.

1986 • 402 citations

Mlab — A mathematical modeling tool

1979 • 391 citations

Fluorouracil and recombinant alfa-2a-interferon: an active regimen against advanced colorectal carcinoma.

1989 • 336 citations

Noncompartmental Determination of the Steady-State Volume of Distribution for Any Mode of Administration

1982 • 288 citations

Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer.

1989 • 246 citations

Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy.

1990 • 231 citations

Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: a randomized trial of the Northern California Oncology Group.

1989 • 184 citations

Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line.

1990 • 182 citations

Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergistic interactions with halogenated pyrimidine antimetabolites.

1988 • 154 citations

Phase II study of fluorouracil and recombinant interferon alfa-2a in previously untreated advanced colorectal carcinoma.

1990 • 145 citations

Interaction of fluorouracil and interferon in human colon cancer cell lines: cytotoxic and cytokinetic effects.

1990 • 128 citations

Pharmacokinetics of fluorouracil in humans.

1978 • 118 citations

Inhibition of antipyrine metabolism by interferon.

1986 • 109 citations

5-Fluorouracil and folinic acid in the treatment of metastatic colorectal cancer: a randomized comparison. A Southwest Oncology Group Study.

1987 • 84 citations

Interferon potentiates cytotoxic effects of 5-fluorouracil on cell proliferation of established human cell lines originating from neoplastic tissues

1983 • 73 citations

Clinical pharmacology of 5-iodo-2′-deoxyuridine and 5-iodouracil and endogenous pyrimidine modulation

1985 • 67 citations

Effects of alpha‐interferon on theophylline pharmacokinetics and metabolism.

1989 • 58 citations

In vitro and in vivo studies on potentiation of cytotoxic effects of anticancer drugs or cobalt 60 gamma ray by interferon on human neoplastic cells

1984 • 55 citations

Phase I trial of 5-fluorouracil and recombinant alpha 2a-interferon in patients with advanced colorectal carcinoma.

1990 • 53 citations

Modulation of 5-fluorouracil-induced toxicity in mice with interferon or with the interferon inducer, polyinosinic-polycytidylic acid.

1983 • 52 citations

Rat but not human interferons suppress hepatic oxidative drug metabolism in rats

1989 • 36 citations

Modulation of chemotherapeutic drug activity with polyribonucleotides or with interferon.

1985 • 21 citations

Synergistic antitumor effect of fluoropyrimidines and polyinosinic-polycytidylic acid against L1210 leukemia.

1985 • 14 citations

Combined effect of 5-fluorouracil and interferon on experimental liver metastases of rat colon carcinoma

1985 • 12 citations