Interaction of fluorouracil and interferon in human colon cancer cell lines: cytotoxic and cytokinetic effects.

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1984 • 6,841 citations

A Detergent‐trypsin method for the preparation of nuclei for flow cytometric DNA analysis

1983 • 1,681 citations

New Human Tumor Cell Lines

1975 • 974 citations

Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.

1989 • 911 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate

1974 • 619 citations

The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group.

1989 • 561 citations

Criteria for Analyzing Interactions between Biologically Active Agents

1981 • 454 citations

Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: a review.

1990 • 351 citations

Fluorinated Pyrimidines and Their Nucleosides

1975 • 333 citations

Murine NK cell cultures: effects of interleukin-2 and interferon on cell growth and cytotoxic reactivity.

1981 • 317 citations

Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.

1981 • 287 citations

Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H–2 gene

1986 • 252 citations

Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism

1978 • 175 citations

Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergistic interactions with halogenated pyrimidine antimetabolites.

1988 • 154 citations

In vivo anti‐tumor activity of combinations of interferon alpha and interleukin‐2 in a murine model. Correlation of efficacy with the induction of cytotoxic cells resembling natural killer cells

1987 • 146 citations

Clinical update on the role of fluorouracil and recombinant interferon alfa-2a in the treatment of colorectal carcinoma.

1990 • 134 citations

Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule.

1988 • 131 citations

Interferon effects upon fluorouracil metabolism by HL-60 cells

1989 • 121 citations

Chemotherapy of large bowel cancer.

1982 • 104 citations

Interaction of recombinant interferons with recombinant interleukin‐2: Differential effects on natural killer cell activity and interleukin‐2‐activated killer cells

1986 • 101 citations

Effect of Human Recombinant Alpha-2-and Gamma-Interferon on the Growth of Human Cell Lines from Solid Tumors and Hematologic Malignancies

1985 • 71 citations

Sequential methotrexate and 5-fluorouracil: mechanisms of synergy.

1983 • 46 citations

Potentiation of the Antiviral and Anticellular Activities of Interferons by Mixtures of HuIFN-γ and HuIFN-α or HuIFN-β

1985 • 41 citations

Mechanisms of combined effects of gamma-interferon and 5-fluorouracil on human colon cancers implanted into nude mice.

1989 • 40 citations

Synergistic inhibition of the growth of adenocarcinoma 755 by the combination of interleukin-2 and interferon-.BETA..

1986 • 10 citations