Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Regression Models and Life-Tables

1992 • 27,454 citations

Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease

1959 • 14,850 citations

A generalized Wilcoxon test for comparing arbitrarily singly-censored samples

1965 • 3,333 citations

Sequential Treatment Assignment with Balancing for Prognostic Factors in the Controlled Clinical Trial

1975 • 2,224 citations

A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma.

1988 • 513 citations

A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma.

1987 • 452 citations

cis-Dichlorodiammineplatinum(II): combination chemotherapy and cross-resistance studies with tumors of mice.

1979 • 405 citations

Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil and high-dose folinic acid.

1986 • 402 citations

Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.

1981 • 287 citations

Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism

1979 • 251 citations

Schedule-dependent antitumor effects of methotrexate and 5-fluorouracil.

1977 • 191 citations

Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.

1986 • 162 citations

The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.

1986 • 140 citations

The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.

1981 • 138 citations

Modulation of 5-fluorouracil metabolism and cytotoxicity by antimetabolite pretreatment in human colorectal adenocarcinoma HCT-8.

1981 • 109 citations

Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.

1987 • 70 citations

An update on the biochemistry of 5-fluorouracil

1981 • 68 citations

Serum distribution of citrovorum factor and 5-methyltetrahydrofolate following oral and im administration of calcium leucovorin in normal adults.

1978 • 35 citations

Cisplatin plus 5-FU for the treatment of adenocarcinoma of the colon.

1985 • 25 citations

Clinical Trial of Cisplatin and Intensive Course 5-Fluorouracil for the Treatment of Advanced Colorectal Cancer

1986 • 14 citations